40 results on '"Cherny, Robert A."'
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2. A novel approach to rapidly prevent age-related cognitive decline.
3. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity.
4. Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation.
5. Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays.
6. Overexpression of Aβ is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model.
7. Radioiodinated clioquinol as a biomarker for β-amyloid: Zn2+ complexes in Alzheimer's disease.
8. Methionine regulates copper/hydrogen peroxide oxidation products of Aβ.
9. Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid β-peptide by NMR.
10. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.
11. Intracellular Accumulation of Detergent-Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice.
12. Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.
13. Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β-amyloid.
14. AN EXPLORATORY MOLECULAR IMAGING STUDY TARGETING Aβ WITH A NOVEL 8-OH QUINOLINE IN ALZHEIMER’S DISEASE (THE PBT2-204 IMAGINE STUDY).
15. Metal chaperones: An integrated approach to the treatment of Alzheimer's disease.
16. The Alzheimer's therapeutic PBT2 achieves cognitive benefit by combining neuroprotection with neurorestoration: studies in animal models of Alzheimer's disease and Huntington's disease.
17. Glutaminyl cyclase activity is decreased in Alzheimer's cerebrospinal fluid.
18. The role of autophagy in potentially therapeutic copper complexes.
19. P3-396: Zinc transport across SH-SY5Y plasma membranes.
20. P2-416: Clioquinol mediates the cellular uptake of Alzheimer's disease amyloid-β peptide and copper.
21. P2-293: Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease.
22. P2-292: Second generation MPAC PBT2 inhibits tau phosphorylation and promotes Aβ degradation.
23. O3-05-04: The 8-hydroxyquinoline analog PBT2 rapidly restores cognition and reduces soluble Abeta in Alzheimer transgenic mice.
24. P4-435: PBT2, a novel MPAC for the treatment of Alzheimer’s disease.
25. P4-283: Clioquinol inhibits the metal-mediated generation of dityrosine and pyroglutamate variants of Abeta.
26. P4-274: Copper-dependent uptake of clioquinol in neuronal cells is promoted by β-amyloid.
27. P4-033: Oxidatively modified soluble Aβ oligomers accumulate progressively in APP-overexpressing mice.
28. P4-019: Positive correlation of brain zinc with Alzheimer’s disease β-amyloid burden.
29. P3-446: Significant reduction in 6-hydroxy-dopamine nigral lesion size by administration of clioquinol.
30. P3-362: Mitochondrial oxidative stress modulates amyloid pathology and the hyperphosphorylation of tau.
31. P3-357: Abeta redox chemistry and neurotoxicity.
32. P3-313: Copper induces accumulation of tau and phosphorylated tau in lipid rafts.
33. P2-025: Copper depletion by menkes ATP7A over-expression dramatically alters the metabolism of APP and APLP2 in cell culture.
34. P2-036: Inhibition of Alzheimer’s disease amyloid-β production causes copper deficiency and decreased Cu/Zn SOD activity.
35. P1-384: Association of AD neuropathological hallmarks with biological metals.
36. P1-056: Aβ overexpression is associated with acceleration of motor impairment and superoxide dismutase 1 aggregation in a mouse model co-expressing APP-C100 and mutant SOD1.
37. O3-03-06: Copper sensitively induces presenilin 1 lipid raft localization with increased amyloidogenic processing of the amyloid precursor protein.
38. The President and the Assassin: McKinley, Terror, and Empire at the Dawn of the American Century - By Scott Miller.
39. Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model.
40. Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease.
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