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Background: Hidradenitis suppurativa is an inflammatory skin disease that presents a recurrence of painful and suppurating lesions in the apocrine gland‐bearing regions, with a strong impact on the patients' life quality. Despite its peculiar presentation, early forms are often underestimated by patients and this would inevitably result in late diagnosis and delayed therapy. Objectives: Improved communication around the disease could facilitate self‐diagnosis and a quicker response from healthcare practitioners, especially in this moment when we dispose of effective treatment against this disease. Methods: A HS awareness campaign was conducted for 2 years with the help of a media agency and a patients' association. Results: Results confirm that a better communication has a strong impact on the disease awareness. Conclusions: This paper demonstrates that the more this disease awareness is carried on, the more quick, effective and efficient the patient's management could be. [ABSTRACT FROM AUTHOR]

We describe a rare case of primary cutaneous marginal zone B-cell lymphoma (PCMZL) in a 33-year-old male affected by hepatitis B virus (HBV)-related chronic active hepatitis. The patient presented with multiple cutaneous papulonodular lesions characterized by polymorphic immunomorphology, with inverse pattern of immunoglobulin light chain restriction in two different lesions, coupled with mucin deposition and anetoderma in a third lesion. The involution of lesions of PCMZL with secondary anetoderma has been previously described, but this has not been reported in the context of multiple lesions showing differing immunoglobulin light chain restriction. We speculate that these findings may be secondary to a variable interaction between a chronic antigenic stimulus (i.e. HBV) and its specific immune response. Ferrara G, Cusano F, Robson A, Stefanato CM. Primary cutaneous marginal zone B-cell lymphoma with anetoderma: spontaneous involution plus de novo clonal expansion. [ABSTRACT FROM AUTHOR]

32 ethylenediamine-sensitive patients were studied to determine cross-sensitivity reactions. Reaction to other aliphatic polyamines proved to be very high, whereas no significant result was obtained to antihistamines, either topically or orally. [ABSTRACT FROM AUTHOR]

A retrospective study of 50 patients with ethylenediamine allergy revealed that 2 topical products containing ethylenediamine as a stabiliser are the main sources of sensitization in Italy, Some of these patients cross-reacted to piperazine and diethylenetriamine, but none to ethylenediamine tetracetic acid. [ABSTRACT FROM AUTHOR]

The article presents a case report on fiberglass dermatitis microepidermic in a primary school. It is said that ten children and two female teachers in the same classroom were brought to the hospital due to acute skin itching eruption. It is confirmed that the eruption is fiberglass dermatitis through skin stripping test which shows transparent fine spicules larger than six micrometers. A discussion on fiberglass dermatitis is presented.

Examines the clinical relevance of patch test in atopic dermatitis patients. Diagnosis of allergic contact dermatitis; Determination of food allergens in patients with the disease; Statistical difference between atopic and nonatopic dermatitis.

A 57-year-old man was seen because of 2 tumour-like warty plaques of the scrotum, which were intensely itchy. A biopsy showed gross hyperkeratosis with acanthosis and papillomatosis in the epidermis and a chronic inflammatory infiltrate in the dermis. The diagnosis of giant lichenification of Pautrier was made and Locorten Tar ointment was prescribed. 20 days later, the patient returned beta use eczema had appeared on the scrotum and left upper thigh. Patch tests with the GIRDCA standard series, Locorten Tar as is, its constituents, and wood tars gave positive reactions to Locorten Tar as is, coal tar and wood tars.

A 66 year-old woman with severe arthrosteitis of the knees was seen for severe pruritus of the knees and legs. When examined, only slight erythema and excoriations were visible. The GIRDCA standard series, 3 topical medicaments that she had been applying to that area, as well as their individual constituents, were patch tested with negative results. The condition cleared witha corticosteroid cream, but relapsed when the ketoprofen gel was used again. The arlypropionic acid derivatives are frequently resposible for allergic and photoallergic contact dermatitis.

This article describes case study of contact dermatitis and photo-dermatitis caused by using a non-steroidal anti-inflammatory drug ketoprofen with analgesic activity advocated with the treatment of pain. Ketoprofen is used as a topical treatment for rheumatic pain, sport injuries or bruises. The most frequent clinical feature is a red swollen area with mild vesiculation but there are also some vesicular dermatitis cases. Patch testing is used to diagnose the symptoms of contact dermatitis.

Recently, a transdermal therapeutic system (TTS) containing nicotine has been marketed to help people to stop smoking. Available at different dosages, it consists of an aluminium chamber containing nicotine dispersed in carrageen, a polysaccharide complex. The article presents cases of contact dermatitis due to drugs or other components of TTS, long-term occlusion and optimaI penetration facilitating sensitization. Nicotine TTS gives irritant reactions in many users and can also cause contact urticaria.

Sensitivity to the quaternary ammonium cationic detergent benzalkonium chloride, a mixture of alkyl dimethyl- benzylammonium chlorides is infrequent, albeit not rare, from its use as a preservative in cosmetics and in topical, opthalmic, and nasal medicaments. It is also used as a preoperative skin disinfectant and sometimes for the sterilization of surgical instruments. Because sterilization of equipment and protection of patients and dental practitioners has became extremely important, allergy to glutaraldehyde and other sterilizing agents may come to be seen more frequently.

A 23-year-old female with haemorrhoids presented with severe eczema, spreading from the perianal region to her buttocks and upper thighs. She had been applying a local anaesthetic product containing pramoxine hydrochloride 1% to relieve burning and pain for a long time. Patch tests gave the results shown below, readings being made at 2 and 3 days. Although the patient was not available for further testing with pure pramoxine, the results of patch tests strongly indicated that the drug was reponsible for the eruption.

Most antihistamines are essentially related at their structural core by a substituted ethylamine group. Depending on the nature of the element that links the ethylamine group to the rest of the compound, the antihistamine belongs to a specific class. A 16-year-old girl had hand eczema due to glues that she handled in a pottery factory. Treatment with many different topical medicaments resulted in periodic exacerbations of the dermatitis, with spread to the forearms and face. Topical sensitization from carbon linked antihistamines will also become a problem, as their topical use increases.

This article presents information on allergic contact dermatitis from viruserol ointment due to tromantadine hydrochloride. A 26-year-old woman with recurrent herpes simplex on her left cheek developed contact dermatitis after a week application of Viruserol® ointment. Patch test to the ointment was strongly positive and among its components only five substances could be patch tested, which gave negative results. Tromantadine hydrochloride was one of the component and showed negative result to the patch test.

Atopic dermatitis (AD) therapeutic approach calls for a long-term treatment. Treatment options for AD have recently undergone a revolutionary change by the introduction of the first biologic drug. Availability in daily practice of the last version of international AD guidelines, taking peculiarities of the country into account, can contribute to good clinical practice in Italy. To adapt European Dermatology Forum (EDF) guidelines for AD to the Italian medical-legal context, the EDF guidelines were assessed independently by two independent Italian renowned experts in the field and further integrated with articles published and systematically reviewed before May 2019. The first draft was collegially corrected and updated by the members of the SIDEMAST, ADOI, and SIDAPA. Recommendation levels (A; B; C; D) were graded based on the evidence levels (1-4). The adapted guidelines presented here focus on topical and systemic therapies in AD patients, both children and adults. As opposed to previous Italian guidelines, they include indications about biologics. New relevant evidence available from very recent literature and peculiarities of the Italian medical and legal context have been integrated in the revision process. If compared to general guidelines for AD not adapted to a specific national and cultural context, a revision for specific Italian needs is now available: It comprises the option of implementing the new biologic treatments and is likely to provide an important contribution to the improvement of clinical practice in Italy. Cooperation between patients, dermatologists, allergologists, and pediatricians remains mandatory in AD management. The authors of the present revision recommend an update of the Italian guidelines to be performed at least every second year., (© 2019 Wiley Periodicals, Inc.)