Search

Keywords: favism; G6PD activity; laboratory diagnosis; G6PD assay; haemolysis EN favism G6PD activity laboratory diagnosis G6PD assay haemolysis 24 38 15 03/31/20 20200401 NES 200401 Methodology This guideline was compiled according to the BSH process at: http://b-s-h.org.uk/guidelines/proposing-and-writing-a-new-bsh-guideline/. G6PD testing in sickle cell disease and thalassaemic disorders is nevertheless recommended to avoid exposure of G6PD-deficient individuals to oxidant drugs or other agents that may exacerbate anaemia in the context of chronic haemolysis. In heterozygous females, the impact of selective haemolysis of G6PD-deficient red cells may compound the effect of reticulocytosis and the enzyme activity of residual non-deficient cells can mask the diagnosis of G6PD deficiency. Where G6PD deficiency is suspected on clinical grounds and no alternative explanation for haemolysis is forthcoming a G6PD assay should be repeated at least 2-3 months after resolution of the haemolytic episode. [Extracted from the article]

This companion paper to the introduction of the International League Against Epilepsy ( ILAE) 2017 classification of seizure types provides guidance on how to employ the classification. Illustration of the classification is enacted by tables, a glossary of relevant terms, mapping of old to new terms, suggested abbreviations, and examples. Basic and extended versions of the classification are available, depending on the desired degree of detail. Key signs and symptoms of seizures (semiology) are used as a basis for categories of seizures that are focal or generalized from onset or with unknown onset. Any focal seizure can further be optionally characterized by whether awareness is retained or impaired. Impaired awareness during any segment of the seizure renders it a focal impaired awareness seizure. Focal seizures are further optionally characterized by motor onset signs and symptoms: atonic, automatisms, clonic, epileptic spasms, or hyperkinetic, myoclonic, or tonic activity. Nonmotor-onset seizures can manifest as autonomic, behavior arrest, cognitive, emotional, or sensory dysfunction. The earliest prominent manifestation defines the seizure type, which might then progress to other signs and symptoms. Focal seizures can become bilateral tonic-clonic. Generalized seizures engage bilateral networks from onset. Generalized motor seizure characteristics comprise atonic, clonic, epileptic spasms, myoclonic, myoclonic-atonic, myoclonic-tonic-clonic, tonic, or tonic-clonic. Nonmotor (absence) seizures are typical or atypical, or seizures that present prominent myoclonic activity or eyelid myoclonia. Seizures of unknown onset may have features that can still be classified as motor, nonmotor, tonic-clonic, epileptic spasms, or behavior arrest. This 'users' manual' for the ILAE 2017 seizure classification will assist the adoption of the new system. [ABSTRACT FROM AUTHOR]

Common symptoms of focal seizures include hot or cold skin sensations or a "rising sense" through the body. E.P. has received speaker and/consultancy fees from Biogen, Eisai, GW Pharma, Sanofi, Takeda, and UCB. S.W. has received unrestricted educational grants from UCB Pharma and Eisai. [Extracted from the article]

Discusses epilepsy from the patient's perspective. Perception of discrimination; Effects of seizures and medication on unborn children; Epilepsy education for family physicians.