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Summary: In this study, an optimal double frequency second order generalized integrator (DFSOGI) based grid side converter control (GSC) is used for monitoring active power injection from the DFIG wind energy system as well as improving power quality at utility grid terminals. The reference DC voltage is adapted to variations in voltage at the point of common coupling (PCC) that reduces the burden on the converter switches and switching losses. In addition, an intelligent control technique based on white shark optimization algorithm (WSO) is endorsed, where an objective problem is formulated to obtain the desired parameters of the controller. Finally, time‐domain simulations are conducted in MATLAB environment that demonstrate the validity of the implemented control over various operating conditions. To affirm the adequacy of the proposed control strategy, the response of DC link voltage obtained through optimal tuning is compared to the conventional one. The proposed WSO tuning outperforms traditional manual tuning pertaining to enhancing the overall performance of the DFIG system. The designed WSO gains exhibit better steady‐state and transient performance including settling time, steady‐state error, and peak of over amplitude and harmonic distortion. The grid currents' total harmonic distortion (THD) is within 5% that meets specified IEEE‐519 standard. [ABSTRACT FROM AUTHOR]

Aims: Heart failure patients with mid‐range ejection fraction (HFmrEF) have overlapping clinical features, compared with patients with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). We aim to perform a meta‐analysis of studies reporting long‐term outcomes in HFmrEF compared with HFrEF and HFpEF. Methods and results: Data from 18 eligible large‐scale studies including 126 239 patients were pooled. Patients with HFmrEF had a lower risk of all‐cause death than those with HFrEF [risk ratio (RR) = 0.92; 95% CI = 0.85–0.98; P < 0.001]. This significant difference was seen in the follow‐up at 1, 2, and 3 years. Patients with HFmrEF had significantly lower risk of cardiovascular (CV) deaths than HFrEF (RR = 0.77; 95% CI = 0.65–0.92; P < 0.001). Subgroup analysis showed that studies recruiting >50% of males had higher risk of deaths with HFrEF (RR = 1.15; 95% CI = 1.04–1.26; P = 0.006). When compared with HFpEF, patients with HFmrEF had comparable risk of all‐cause death (RR = 1.02; 95% CI = 0.96–1.09; P = 0.53). Similarly, there were no differences in the 1, 2, and 3 year deaths; CV and non‐CV deaths were insignificant between HFmrEF and HFpEF. Conclusions: The results of the study support that HFmrEF has better prognosis than HFrEF but similar prognosis when compared with HFpEF. Gender disparity between studies seems to influence the results between HFmrEF and HFrEF. Transition in left ventricular ejection fraction (LVEF), which could not be addressed in the study, may play a decisive role in determining outcomes. PROSPERO review registration number CRD42021277107. [ABSTRACT FROM AUTHOR]

The transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with bidentate Schiff base ligands (HL1−5) were obtained from condensation of 1, 2, 3, 4‐tetrahydro‐naphthalen‐1‐ylamine with methanolic solution of 3‐hydroxy‐salicylaldehyde, 4‐hydroxy‐salicylaldehyde, 5‐bromo‐salicylaldehyde, 3,5‐dibromo‐salicylaldehyde, and 2‐hydroxy‐1‐napthaldehyde. The synthesized compounds were structurally elucidated by spectral and physical methods. The spectral characterization emphasized bidentate nature (NO) of Schiff base ligands which gets chelated with metal via nitrogen atom of imine group and deprotonated oxygen of salicylaldehyde/2‐hydroxy‐1‐napthaldehyde group to form octahedral geometry around metal atom. Thermal results supported that the complexes are stable upto 200°C leaving metal oxide as an end products. The reported compounds (1–25) in this series were screened against the bacterial strains, that is, two Gram positive: Bacillus subtilis and Staphylococcus aureus, two Gram negative: Pseudomonas aeruginosa and Escherichia coli, and two fungal strains: Candida albicans andAspergillus niger and their results that indicated moderate to good activity with compounds 20 and 21 having good antimicrobial activity (minimum inhibitory concentration [MIC] value 0.0269–0.0067 μmol/ml) as compared with control drugs ciprofloxacine and fluconazole. Furthermore, cytotoxic studies of synthesized compounds were carried out against three human cancer cell lines: HCT‐116 (colon), A549 (alveolar), and MCF‐7 (breast) using standard drug paclitaxel. The results demonstrated that compounds 1 (IC50 values = 12.93, 15.13, 17.24), 3 (11.9, 9.29, 12.64), 9 (17.06, 20.06, 22.87), 14 (16.21, 18.47, 20.00), and 25 (17.54, 17.21, 20.23) for three cancer cell lines were found to be most potent candidates among the synthesized compounds. [ABSTRACT FROM AUTHOR]

A series of novel pyrrole fused benzoxazinones/quinoxalinones has been evaluated for antiproliferative activity against breast cancer cell line, MCF7 and treatment‐resistant triple‐negative breast cancer cell line MDA‐MB‐231. Among which pyrroloquinoxalinones exhibited higher cytotoxicity. Furthermore, they showed insignificant cellular cytotoxicity in normal human cell HEK293T when treated with their respective IC50 concentrations. In silico molecular docking, study suggests that the inhibitory mechanism of pyrroloquinoxalinones probably mediated via modulation of breast cancer targets such as VEGFR2 and EGFR. The stability of target protein (VEGFR2 and EGFR)‐ligand (pyrroloquinoxalinones) interactions was validated by Molecular dynamic simulation (50 ns). Additionally, pyrrolobenzoxazinones/quinoxalinones were evaluated for in vitro antibacterial activity against Gram‐positive and Gram‐negative bacterial strains. All the compounds exhibited significant antibacterial activity (IC50 0.034–15.4 μM) towards the tested bacterial strains. These findings indicate that pyrrolobenzoxazinones/quinoxalinones are valuable scaffolds for the development of potent anticancer and antibacterial compounds. [ABSTRACT FROM AUTHOR]

This study presents a strategy involving a reduction in the stator current sensor count for control of power converters, in a doubly fed induction generator (DFIG)‐based wind energy conversion system (WECS). The reduced sensor vector control scheme is effectively used in lieu of the conventional vector control algorithm during sensor failure without any change in the overall control structure. This keeps the system operational in case of sensor failure. The reduced sensor scheme necessitates precise estimation of stator flux amplitude and an orientation angle, for control of power converters under all operating conditions. A composite generalised integrator phase‐locked loop is presented to estimate accurately the stator flux amplitude and orientation angle, even at operating system irregularities such as unbalanced voltages, lower‐order harmonics in the grid voltage, DC bias in sensing circuitry, and so forth, which otherwise lead to distortions in flux and orientation angle. The grid‐side converter control is based on a twin frequency improved second‐order generalised integrator. It enables fast and accurate power quality improvement in DFIG‐based WECS during load and grid abnormalities. A laboratory prototype is developed to validate the control of the system. [ABSTRACT FROM AUTHOR]

Tetrazolo[1,5‐a]quinoline‐4‐carbaldehyde, 3‐oxo‐3‐phenylpropanenitrile, and β‐enamine were reacted in one‐pot to obtain highly functionalized quinolinyl‐1,4‐dihydropyridines. In addition to spectroscopic characterization, the structure of one of the compound is confirmed by single‐crystal X‐ray diffraction. Among all compounds evaluated for cytotoxic effect against MCF7, three quinolinyl‐1,4‐dihydropyridines (SKS13, 19, and 20) were found to be most active with half inhibition concentrations value of 7.87–9.55 μM. Molecular docking of the active molecules to various breast cancer targets revealed effective compounds have multiple receptor targeting potential in breast cancer. Our results corroborate quinolinyl‐1,4‐dihydropyridines as a valuable scaffold to develop anticancer drugs. [ABSTRACT FROM AUTHOR]

Traumatic coronary artery (CA) dissection is an extremely rare sequela of blunt chest trauma. Diagnosis of CA dissection in the setting of chest trauma is challenging. While conventionally coronary angiography has been the diagnostic tool of choice, modern imaging techniques such as optical coherence tomography can further improve diagnostic accuracy and help optimise treatment strategy. The ideal treatment modality for managing CA dissection has not been established with case reports revealing a range of treatment strategies ranging from CA bypass grafting to a completely conservative management. Here we present a case report of a 68‐year‐old man who suffered a traumatic proximal left anterior descending artery dissection as a consequence of a motor‐vehicle accident and was subsequently treated with a combination of conservative and interventional strategy with optimal patient outcome. [ABSTRACT FROM AUTHOR]

The SE Ladakh (India) area displays one of the best ‐preserved ophiolite sections in this planet, in places up to 10 km thick, along the southern bank of the Indus River. Recently, in situ ultra‐high pressure (UHP) microstructural evidences from mantle transition zone (MTZ ∼ 410–660 km) with diamond and reduced fluids were discovered from two peridotite bodies in the basal mantle part of this Indus ophiolite (Das et al., 2015; 2017). Ultrahigh‐pressure phases were also found by early workers from podiform chromitites of another equivalent Neo–Tethyan ophiolite in southern Tibet (e.g., Yang et al., 2007; Yamamoto et al., 2009). However, the MTZ phases in the Indus ophiolite are found in silicate peridotites not metallic chromitites and the peridotitic UHP phases show systematic and contiguous phase transitions from the MTZ to shallower depth, unlike the discrete ultrahigh‐pressure inclusions, all in Tibetan chromitites. The gradual change in oxygen fugacity (fo2) and fluid composition from (C‐H + H2) to (CO2 + H2O) in the upwelling peridotitic mantle causing melting to produce MORB. At shallow depths (< 100 km) the free water stabilizes into hydrous phases, such as amphiboles and serpentines, capable of storing water and prevent melting (Fig. 1). The results from Indus ophiolite provide unique insights into deep sub‐oceanic mantle processes, and link deep mantle upwelling and MORB genesis (Fig. 1). The tectonic setting of Neo‐Tethyan ophiolites has been a difficult problem since the birth of plate tectonics concept. This problem for the origin of ophiolites in mid‐ocean ridge versus supra subduction‐zone settings clearly confused the Geoscience community. However, Indian Ocean –type isotopic characteristics are present in Neo‐Tethyan ophiolites (Zhang et al., 2005). Recently, continental materials (quartz, k‐feldspar etc.) bearing old zircons (up to 2700 Ma) are also recovered from UHP chromitite of Tibetan ophiolite (Yamamoto et al., 2013). Eventually, the presence of older continental material can produce non‐MORB like basalts in Neo‐Tethyan ophiolites in mid‐oceanic‐ridge following the "historical contingency" model (Moores et al., 2000). [ABSTRACT FROM AUTHOR]

We report the case of a pregnancy in a 25-year-old woman who was born with ectopia vesicae and split pelvis, but had not undergone any reconstructive or diversion surgery in childhood. Her antenatal period was uneventful and the infant was delivered by cesarean section at term due to breech presentation. The baby had no congenital anomalies. The postoperative period was uneventful and they were discharged from the hospital in a good general condition. [ABSTRACT FROM AUTHOR]

Keywords: Acute coronary syndrome; Myocardial infarction; Cardiology, interventional; Coronary artery disease; Electrocardiography; Chemotherapy; Drug-related side effects and adverse reactions If the patient is at high risk of coronary artery disease, as in our example, it is advised to perform a prompt coronary angiogram to identify an alternative pathological process driving the patient's symptoms. One example would be in patients with chest pain after exposure to 5-FU who are found to have significant coronary artery disease and undergo revascularisation and for whom no other reasonable treatment options are available. [Extracted from the article]