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Evaluates the cross-reactivity between the topical corticosteroids budesonide and desonide. Classification of topical corticosteroids into four cross-reacting groups.

22 cases of allergic contact dermatitis from topical corticosteroids were observed in Strasbourg and previously published 7 further cases are reported here and the vehicle and concentration of corticosteroids for patch tests are discussed. A 0.1% concentration in petrolatum seemed adequate for testing the 4 molecules (triamcinolone acetonide, dexamethasone, desonide and amcinonide) responsible for the 7 new, cases. In 1 case, several cross-reactions were seen. A corticosteroids screening series permits patch testing of the suspected molecule(s) in a selective way. Without this series, long delays arc required to make [he correct diagnosis by patch testing. We have reviewed more than 60 paper on corticosteroids allergy published up to now. [ABSTRACT FROM AUTHOR]

Allergic contact sensitivity to tropical corticosteroids has been reported with increasing frequency in recent years. A 26-year-old woman, with dermatitis of the upper limbs, had been affected by crythema, vesicles and scaling. During this time, she had used a large number of topical corticosteroids, which had worsened her dermatitis. Budesonide, a non-halogenated moderately potent steroid, was synthesized in 1979 and has been supplied since 1989 in Italy by IDI Farmaceutici in three preparations: cream, lotion and ointments. Budesonide contained in a nasal spray and in ointments has been responsible for contact allergy.