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Lingshuine 1, a novel sesquiterpene amide, along with three known Ncontaining compounds, 2–4, have been isolated from the Hainan sponge Axinyssa variabilis.The structure of 1was elucidated by detailed analysis of the spectroscopic data and by chemical methods. Lingshuine represents the first example of a Passeriniproduct formed during the isolation process. [ABSTRACT FROM AUTHOR]

Two new cembrane diterpenes, sinulaparvalides A and B 1and 2, resp., which contain an intriguing sevenmembered lactone moiety, along with the four known related cembranoids 3–6, were isolated from the Hainan soft coral Sinularia parva.The structures of compounds 1and 2were established by spectroscopic methods, mainly on the basis of 2DNMR techniques, and were confirmed by singlecrystal Xray diffraction analysis. The in vitrocytotoxic activities of these compounds were tested on human colon carcinoma HCT116, human promyelocytic leukemia HL60, and human lung carcinoma A549 tumor cell lines. [ABSTRACT FROM AUTHOR]

From the soft bodied coral Sarcophyton glaucumcollected from the South China Sea two new cembranoids, 7R,8Sdihydroxydeepoxyentsarcophine 1 and secosarcophinolide 2, together with one known related compound, entsarcophine 3, were isolated. The structures of the new compounds were determined by extensive analysis of their spectroscopic data and chemical correlation. The absolute configuration of 1was determined by chemical correlation with 3and by comparison of its optical rotation value with that of its corresponding enantiomer, 7S,8Rdihydroxydeepoxysarcophine 5. [ABSTRACT FROM AUTHOR]

Two new biscembranoids, ximaolides F 1 and G 2, were isolated from the Hainan soft coral Sarcophyton tortuosum.The structures and relative configurations of the two new compounds were elucidated by the combination of spectroscopic methods, chemical conversion of ximaolide F 1 into ximaolide G 2, and comparison with related model compounds. [ABSTRACT FROM AUTHOR]

Four new highly oxygenated guaiane lactones, 1-epimenverin B (1), menverin F (2), 1-deoxymenverin F (3), and menverin G (4), together with the two known related analogues menverins B (5) and C (6), were isolated from the South China Sea gorgonian Menella sp. Their structures and relative configuration were elucidated by analysis of spectroscopic data and by comparison with those of known related compounds. [ABSTRACT FROM AUTHOR]