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The location of osteoporotic fragility fractures adds crucial information to post‐fracture risk estimation. Triaging patients according to fracture site for secondary fracture prevention can therefore be of interest to prioritize patients considering the high imminent fracture risk. The objectives of this cross‐sectional study were therefore to explore potential differences between central (vertebral, hip, proximal humerus, pelvis) and peripheral (forearm, ankle, other) fractures. This substudy of the Norwegian Capture the Fracture Initiative (NoFRACT) included 495 women and 119 men ≥50 years with fragility fractures. They had bone mineral density (BMD) of the femoral neck, total hip, and lumbar spine assessed using dual‐energy X‐ray absorptiometry (DXA), trabecular bone score (TBS) calculated, concomitantly vertebral fracture assessment (VFA) with semiquantitative grading of vertebral fractures (SQ1–SQ3), and a questionnaire concerning risk factors for fractures was answered. Patients with central fractures exhibited lower BMD of the femoral neck (765 versus 827 mg/cm2), total hip (800 versus 876 mg/cm2), and lumbar spine (1024 versus 1062 mg/cm2); lower mean TBS (1.24 versus 1.28); and a higher proportion of SQ1‐SQ3 fractures (52.0% versus 27.7%), SQ2–SQ3 fractures (36.8% versus 13.4%), and SQ3 fractures (21.5% versus 2.2%) than patients with peripheral fractures (all p < 0.05). All analyses were adjusted for sex, age, and body mass index (BMI); and the analyses of TBS and SQ1–SQ3 fracture prevalence was additionally adjusted for BMD). In conclusion, patients with central fragility fractures revealed lower femoral neck BMD, lower TBS, and higher prevalence of vertebral fractures on VFA than the patients with peripheral fractures. This suggests that patients with central fragility fractures exhibit more severe deterioration of bone structure, translating into a higher risk of subsequent fragility fractures and therefore they should get the highest priority in secondary fracture prevention, although attention to peripheral fractures should still not be diminished. © 2019 American Society for Bone and Mineral Research. © 2019 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research. [ABSTRACT FROM AUTHOR]

Objective: To examine whether the 1-year effects from a previous walking skill training program on walking and stair climbing still persist 5 years following total hip arthroplasty (THA), to examine recovery of physical functioning from before to 5 years after surgery, and to identify predictors of physical activity 5 years after THA from preoperative measures.Methods: We performed a 5-year followup of a randomized controlled trial and a longitudinal study. Sixty participants with a mean age of 70 years (range 50-87 years; 95% confidence interval 68, 72 years) were assessed. Outcome measures were the 6-minute walk test, the stair climbing test (SCT), active hip range of motion (ROM), self-efficacy, Hip Dysfunction and Osteoarthritis Outcome Score (HOOS), and University of California, Los Angeles (UCLA) activity scale. Data were analyzed by Student's t-tests, generalized linear model, and multivariate regression analyses.Results: The training and control groups were approximately equal on outcome measures of physical functioning, pain, and self-efficacy at 5 years (P > 0.05). In the total group, the recovery course was unchanged from 1 to 5 years (P > 0.05), except for 9% improvement in ROM (P < 0.001) and an increase in time on SCT of 18% (P = 0.004). Preoperative HOOS pain (P = 0.022) and HOOS sport (P = 0.019) predicted UCLA activity scale 5 years after THA.Conclusion: At 5 years after THA, the control group had caught up with the training group on physical functioning, and the participants led an active lifestyle. Those with worse preoperative scores on pain and physical functioning in sport were at risk of being less physically active in the long term following THA. [ABSTRACT FROM AUTHOR]

Radiostereometry (RSA) is considered to be the most precise and accurate method for wear-measurements in total hip replacement. Post-operative stereoradiographs has so far been necessary for wear measurement. Hence, the use of RSA has been limited to studies planned for RSA measurements. We compared a new RSA method for wear measurements that does not require previous radiographs with conventional RSA. Instead of comparing present stereoradiographs with post-operative ones, we developed a method for calculating the post-operative position of the center of the femoral head on the present examination and using this as the index measurement. We compared this alternative method to conventional RSA in 27 hips in an ongoing RSA study. We found a high degree of agreement between the methods for both mean proximal (1.19 mm vs. 1.14 mm) and mean 3D wear (1.52 mm vs. 1.44 mm) after 10 years. Intraclass correlation coefficients (ICC) were 0.958 and 0.955, respectively ( p < 0.001 for both ICCs). The results were also within the limits of agreement when plotted subject-by-subject in a Bland-Altman plot. Our alternative method for wear measurements with RSA offers comparable results to conventional RSA measurements. It allows precise wear measurements without previous radiological examinations. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 480-484, 2013 [ABSTRACT FROM AUTHOR]

Johnsen BO, Rønning EJ, Onken A, Figved W, Jenum PA. Dolosigranulum pigrum causing biomaterial-associated arthritis. APMIS 2010; 119: 85-7. Dolosigranulum pigrum is a gram-positive, catalase-negative bacteria rarely associated with disease. We report a case of biomaterial-associated arthritis in an immunocompetent patient caused by D. pigrum. The organism was isolated from a synovial biopsy specimen and its identity confirmed by 16S rRNA gene sequencing. [ABSTRACT FROM AUTHOR]