1. Diurnal variations in flow density measured using optical coherence tomography angiography and the impact of heart rate, mean arterial pressure and intraocular pressure on flow density in primary open-angle glaucoma patients
- Author
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Laura Kerschke, Maged Alnawaiseh, Nicole Eter, Viktoria Constanze Müller, Jens J. Storp, Pieter Nelis, and Faculty of Medicine and Pharmacy
- Subjects
Male ,Intraocular pressure ,genetic structures ,Glaucoma, Open-Angle/diagnosis ,Glaucoma ,Hemodynamics ,Retinal Vessels/diagnostic imaging ,Fluorescein Angiography/methods ,Tomography, Optical Coherence/methods ,chemistry.chemical_compound ,0302 clinical medicine ,Heart Rate ,Macula Lutea ,Fluorescein Angiography ,Capillaries/diagnostic imaging ,General Medicine ,Middle Aged ,Circadian Rhythm ,Circadian Rhythm/physiology ,Female ,Glaucoma, Open-Angle ,Tomography, Optical Coherence ,Heart Rate/physiology ,Macula Lutea/blood supply ,Mean arterial pressure ,medicine.medical_specialty ,Open angle glaucoma ,Fundus Oculi ,Optic Disk ,03 medical and health sciences ,Ophthalmology ,Heart rate ,medicine ,Humans ,Arterial Pressure ,Intraocular Pressure/physiology ,Intraocular Pressure ,Arterial Pressure/physiology ,Retrospective Studies ,Optic Disk/blood supply ,business.industry ,Retinal Vessels ,Retinal ,medicine.disease ,eye diseases ,Capillaries ,Blood pressure ,Cross-Sectional Studies ,chemistry ,030221 ophthalmology & optometry ,sense organs ,Visual Fields ,business ,030217 neurology & neurosurgery - Abstract
PURPOSE: To determine the diurnal variations in peripapillary and macular flow density (FD), as measured using optical coherence tomography angiography (OCTA) and to elaborate on the relationship between diurnal FD, circulatory parameters and intraocular pressure (IOP) variations in primary open-angle glaucoma (POAG). METHODS: Forty eyes of 40 POAG patients were drawn into this cross-sectional study. The retinal microvasculature of the macula (superficial and deep layers) and optic nerve [radial peripapillary capillary (RPC)] was examined by OCTA (AngioVue® , Optovue). Optical coherence tomography angiography (OCTA) measurements were conducted at 08:00, 11:00, 15:00 and 20:00 over the course of two consecutive days. Intraocular pressure (IOP) and circulatory parameters were assessed accordingly. Diurnal variations in FD were analysed using linear mixed models. RESULTS: While superficial macular FD and RPC FD revealed not to be affected by diurnal variations (p = 0.492, p = 0.319), FD in the deep layer of the macula increased throughout the day (p < 0.001). Superficial macular FD was influenced significantly by mean arterial pressure (MAP) (p = 0.006) and heart rate (HR) (p = 0.033), whereas FD in the RPC layer was significantly affected by HR (p = 0.010). No statistically significant effect of IOP fluctuations on FD was observed. CONCLUSION: This study shows diurnal fluctuations of deep macular FD measured by OCTA and outlines the relationship between FD and hemodynamic parameters (MAP/HR) in POAG patients.
- Published
- 2019