20 results on '"Gallardo, F."'
Search Results
2. Prognostic factors in patients with primary cutaneous anaplastic large cell lymphoma: a multicentric, retrospective analysis of the Spanish Group of Cutaneous Lymphoma.
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Fernández‐de‐Misa, R., Hernández‐Machín, B., Combalía, A., García Muret, M.P., Servitje, O., Muniesa, C., Gallardo, F., Pujol, R.M., Martí, R.M., Ortiz‐Brugués, A., Maroñas‐Jiménez, L., Ortiz‐Romero, P.L., Blanch Rius, L., Izu, R., Román, C., Cañueto, J., Blanes, M., Morillo, M., Bastida, J., and Peñate, Y.
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BREAST implants ,CUTANEOUS T-cell lymphoma ,RETROSPECTIVE studies ,LYMPHOMAS ,ACADEMIC departments - Abstract
Background: Reliable prognostic factors for patients with primary cutaneous anaplastic large cell lymphoma (PCALCL) are lacking. Objective: To identify prognostic factors for specific survival in patients with PCALCL. Methods: Using the convenience sampling method, patients with PCALCL diagnosed from May 1986 to August 2017 in 16 University Departments were retrospectively reviewed. Results: One hundred eight patients were included (57 males). Median age at diagnosis was 58 years. All of them showed T1‐3N0M0 stages. Seventy per cent of the cases presented with a solitary lesion, mostly at the limbs. Complete response rate after first‐line treatment was 87%, and no advantage was observed for any of them (surgery, radiotherapy, chemotherapy or other approaches). Nodal and visceral progression rate was 11% and 2%, respectively. 5‐year specific survival (SSV) reached 93%; 97% for T1 patients and 84% for T2/T3 patients (P = 0.031). Five‐year SSV for patients developing early cutaneous relapse was 64%; for those with late or no relapse, 96% (P = 0.001). Estimated median SSV for patients showing nodal progression was 103 months (95% CI: 51–155 months); for patients without nodal progression, estimated SSV did not reach the median (P < 0.001). Nodal progression was an independent predictive parameter for shorter survival (P = 0.011). Conclusion: Multiple cutaneous lesions at presentation, early skin relapse and nodal progression portrait worse prognosis in patients with PCALCL. [ABSTRACT FROM AUTHOR]
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- 2020
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3. Initial results of ixekizumab efficacy and safety in real‐world plaque psoriasis patients: a multicentre retrospective study.
- Author
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Deza, G., Notario, J., Lopez‐Ferrer, A., Vilarrasa, E., Ferran, M., del Alcazar, E., Carrascosa, J.M., Corral, M., Salleras, M., Ribera, M., Puig, L., Pujol, R. M., Vidal, D., and Gallardo, F.
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PSORIATIC arthritis ,DISEASE duration ,PSORIASIS ,BODY mass index ,INDUSTRIAL safety ,RETROSPECTIVE studies - Abstract
Background: Ixekizumab (anti‐IL17A) is effective as treatment for moderate‐to‐severe plaque psoriasis, but real‐life data on effectiveness and safety are currently very limited. Objective: To evaluate the efficacy and safety of ixekizumab in a cohort of real‐life plaque psoriasis patients. Methods: Retrospective chart review of 100 patients with moderate‐to‐severe plaque psoriasis treated with ixekizumab at seven Spanish dermatological centres. Results: According to the as observed analysis, the percentage of patients achieving a 75% and 90% of reduction from the baseline score of Psoriasis Area and Severity Index (PASI) was 87.5%–50.0% at week 12–16; 88.3%–58.4% at week 24 and 82.9%–58.5% at week 52, respectively. The mean ± standard deviation (SD) score of PASI at baseline was 12.9 ± 9.2, and it declined rapidly after ixekizumab administration to 1.9 ± 4.0 (P < 0.001) at week 12–16 and was maintained at 1.7 ± 4.1 and 1.8 ± 2.9 at week 24 and 52, respectively. Ixekizumab response was not affected by clinical variables like body mass index, disease duration or the presence of psoriatic arthritis. However, the bio‐naive group showed significantly higher PASI 75 response rate at week 12–16 compared to patients previously exposed to biologic agents (P = 0.037). Twenty‐six (26%) patients experienced adverse events (AEs) during the follow‐up period, being most of them of mild‐to‐moderate intensity. The most common AE was local reaction at the site of injection (14/26; 53.8%). At the end of the observational period, 15 (15%) patients discontinued ixekizumab treatment due to limited clinical improvement (n = 11), adverse events (n = 3) or lost to follow‐up (n = 1) within a mean ± SD time of 6.0 ± 3.9 months. Conclusion: The present study illustrates the initial experience with ixekizumab in real‐world clinical practice confirming its usefulness and safety in the management of plaque psoriasis patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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4. The Domestic Camelids (Cetartiodactyla: Camelidae) from the Middle Formative Cemetery of Topater 1 (Atacama Desert, Northern Chile): Osteometric and Palaeopathological Evidence of Cargo Animals.
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Labarca, R. and Gallardo, F.
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CAMELIDAE , *MUMMIFIED animals , *ZOOARCHAEOLOGY , *OSTEOMETRY , *PALEOPATHOLOGY - Abstract
The Middle Formative Cemetery of Topater 1 (ca. 500 bc-100 ad), located in the oasis of Calama, Northern Chile, presents an unusually diverse array and quantity of funerary offerings, distributed among the graves of more than 200 individuals. Among the offerings are the remains of several mummified camelids and camelid skeletal elements, primarily distal extremities and artefacts made from the bones of these animals. Taking only the first skeletonised anterior and posterior phalanges of Topater 1 camelids, we conducted univariate and multivariate osteometric analyses in order to assign the sample to the appropriate taxonomic groups. At the same time, we described all osteopathologies registered for the extremities in the collection. Of the 45 phalanges measured, 30 were of similar or greater size than contemporary reference llamas. Fourteen of the 164 samples of bone extremities presented pathologies, most of them first phalanges. These abnormalities included different degrees of exostosis and, less commonly, eburnation and lipping. Considering both lines of evidence, we conclude that the llamas sacrificed at the Topater 1 cemetery correspond to, at least, two very large and robust cargo llama morphotypes. When living, these animals would have transported goods as part of the intense exchange activity that was taking place during this period in the region extending from the Pacific coast to Northwest Argentina and perhaps even beyond. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2015
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5. Metronomic chemotherapy for advanced and refractory cutaneous T-cell lymphoma treatment.
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López Aventín, D., Gallardo, F., Sanchez ‐ Gonzalez, B., Pujol, R.M., and Salar, A.
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CANCER chemotherapy , *T-cell lymphoma , *THERAPEUTICS - Abstract
A letter to the editor is presented in response to the article "Metronomic chemotherapy for advanced and refractory cutaneous T-cell lymphoma treatment," in the previous issue.
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- 2016
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6. Cutaneous lymphomas showing prominent granulomatous component: clinicopathological features in a series of 16 cases.
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Gallardo, F., García-Muret, M. P., Servitje, O., Estrach, T., Bielsa, I., Salar, A., Abella, E., Barranco, C., and Pujol, R. M.
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LYMPHOMAS , *GRANULOMA , *SKIN biopsy , *HISTOPATHOLOGY , *MACROPHAGES , *INFLAMMATION - Abstract
Background The presence of a prominent granulomatous tissue reaction in skin biopsies from primary cutaneous or systemic malignant lymphomas with secondary cutaneous involvement is a rare but well-known phenomenon. Objective This paper aims to characterize and study a series of cutaneous lymphomas showing a prominent granulomatous component. Patients and methods The clinical, histopathological and evolutive features of granulomatous variants of mycosis fungoides (5 patients, 2 of them associating ‘granulomatous slack skin’ features), Sézary syndrome (1 patient), CD30+ cutaneous T-cell lymphoma (2 patients), CD4+ small/medium pleomorphic cutaneous T-cell lymphoma (1 patient), primary cutaneous B-cell lymphoma (3 patients) and peripheral T-cell lymphoma with secondary epithelioid granulomatous cutaneous involvement (4 patients) were reviewed. Results The observed features were clinically non-distinctive. Only those cases presenting with granulomatous slack skin features were clinically suspected (2 patients). Non-necrotizing granulomata (11 patients) and granuloma annulare-like (4 patients) were the most frequently observed histopathological patterns. In five cases, no diagnostic lymphomatous involvement was initially observed. From our series, no definite conclusions regarding prognosis could be established. Conclusion The diagnosis of cutaneous lymphoma may be difficult when a prominent cutaneous granulomatous inflammatory infiltrate obscures the true neoplastic nature of the condition. However, the presence of concomitant lymphoid atypia may help to suspect the diagnosis. In doubtful cases, the clinical evolution and the demonstration of a monoclonal lymphoid B- or T-cell population may lead to a definite diagnosis. Conflicts of interest None declared. [ABSTRACT FROM AUTHOR]
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- 2009
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7. Assembly of a cytosolic pine glutamine synthetase holoenzyme in leaves of transgenic poplar leads to enhanced vegetative growth in young plants.
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FU, J., SAMPALO, R., GALLARDO, F., CÁNOVAS, F. M., and KIRBY, E. G.
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PLANT growth ,GLUTAMINE synthetase ,NITROGEN - Abstract
ABSTRACT Over-expression of glutamine synthetase (GS, EC 6.3.1.2), a key enzyme in nitrogen assimilation, may be a reasonable approach to enhance plant nitrogen use efficiency. In this work phenotypic and biochemical characterizations of young transgenic poplars showing ectopic expression of a pine cytosolic GS transgene in photosynthetic tissue (Gallardo et al ., Planta 210, 19–26, 1999) are presented. Analysis of 22 independent transgenic lines in a 6 month greenhouse study indicated that expression of the pine GS transgene affects early vegetative growth and leaf morphology. In comparison with non-transgenic controls, transgenic trees exhibited significantly greater numbers of nodes and leaves (12%), and higher average leaf length and width resulting in an increase in leaf area (25%). Leaf shape was not altered. Transgenic poplars also exhibited increased GS activity (66%), chlorophyll content (33%) and protein content (21%). Plant height was correlated with GS content in young leaves, suggesting that GS can be considered a marker for vegetative growth. Molecular and kinetic characterization of GS isoforms in leaves indicated that poplar GS isoforms are similar to their counterparts in herbaceous plants. A new GS isoenzyme that displayed molecular and kinetic characteristics corresponding to the octomeric pine cytosolic GS1 was identified in the photosynthetic tissues of transgenic poplar leaves. These results indicate that enhanced growth and alterations in biochemistry during early growth are the consequence of transgene expression and assembly of pine GS1 subunits into a new functional holoenzyme in the cytosol of photosynthetic cells. [ABSTRACT FROM AUTHOR]
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- 2003
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8. Adherence of self-administered subcutaneous methotrexate in patients with chronic plaque-type psoriasis.
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Vidal, D., Salleras, M., Romaní, J., Ribera, M., Gallardo, F., Viñas, M., Xifra, A., García ‐ Navarro, X., Bordas, X., Ferran, M., and Carrascosa, J.M.
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METHOTREXATE ,PSORIASIS ,SELF medication ,PATIENTS - Abstract
A letter to the editor is presented regarding the study that assess the adherence of subcutaneous (SC) methotrexate (MTX) treatment in chronic plaque-type psoriasis patients which is self-administered.
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- 2016
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9. Multiple and extensive lichen planus-like keratoses: an underestimated cutaneous eruption observed in patients with intense sun damage.
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Toll, A., Gilaberte, M., Gallardo, F., Iglesias, M., Barranco, C., and R. M. Pujol
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LETTERS to the editor ,KERATOSIS - Abstract
A letter to the editor is presented concerning multiple and extensive lichen planus-like keratoses.
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- 2006
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10. No tuberculosis reactivations in psoriasis patients initiating new generation biologics despite untreated latent tuberculosis infection: Multicenter case series of 35 patients.
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Manzanares N, Vilarrasa E, López A, Alonso ML, Velasco M, Riera J, Del Alcázar E, Carrascosa JM, Azón A, Rivera R, Santos S, Salgado-Boquete L, Roncero M, Dorado M, Yelamos O, Delgado C, Gallardo F, and Ferran M
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- Humans, Biological Factors, Latent Tuberculosis complications, Latent Tuberculosis drug therapy, Biological Products therapeutic use, Tuberculosis, Psoriasis complications, Psoriasis drug therapy
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- 2024
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11. Brentuximab vedotin in the treatment of cutaneous T-cell lymphomas: Data from the Spanish Primary Cutaneous Lymphoma Registry.
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Muniesa C, Gallardo F, García-Doval I, Estrach MT, Combalia A, Morillo-Andújar M, De la Cruz-Vicente F, Machan S, Moya-Martínez C, Rovira R, Sanchez-Gonzalez B, Acebo E, Amutio E, Peñate Y, Losada-Castillo MDC, García-Muret MP, Iznardo H, Román-Curto C, Cañueto J, Fernández-de-Misa R, Flórez Á, Izu RM, Torres-Navarro I, Zayas A, Pérez-Paredes G, Blanes M, Yanguas JI, Pérez-Ferriols A, Callejas-Charavia M, Ortiz-Romero PL, Pérez-Gil A, Prieto-Torres L, González-Barca E, and Servitje O
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- Female, Humans, Middle Aged, Brentuximab Vedotin therapeutic use, Registries, Ki-1 Antigen, Immunoconjugates adverse effects, Skin Neoplasms pathology, Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides pathology, Sezary Syndrome pathology, Lymphoproliferative Disorders
- Abstract
Background: Brentuximab vedotin (BV) has been approved for CD30-expressing cutaneous T-cell lymphoma (CTCL) after at least one previous systemic treatment. However, real clinical practice is still limited., Objectives: To evaluate the response and tolerance of BV in a cohort of patients with CTCL., Methods: We analysed CTCL patients treated with BV from the Spanish Primary Cutaneous Lymphoma Registry (RELCP)., Results: Sixty-seven patients were included. There were 26 females and the mean age at diagnosis was 59 years. Forty-eight were mycosis fungoides (MF), 7 Sézary syndrome (SS) and 12 CD30+ lymphoproliferative disorders (CD30 LPD). Mean follow-up was 18 months. Thirty patients (45%) showed at least 10% of CD30+ cells among the total lymphocytic infiltrate. The median number of BV infusions received was 7. The overall response rate (ORR) was 67% (63% in MF, 71% in SS and 84% in CD30 LPD). Ten of 14 patients with folliculotropic MF (FMF) achieved complete or partial response (ORR 71%). The median time to response was 2.8 months. During follow-up, 36 cases (54%) experienced cutaneous relapse or progression. The median progression free survival (PFS) was 10.3 months. The most frequent adverse event was peripheral neuropathy (PN) (57%), in most patients (85%), grades 1 or 2., Conclusions: These results confirm the efficacy and safety of BV in patients with advanced-stage MF, and CD30 LPD. In addition, patients with FMF and SS also showed a favourable response. Our data suggest that BV retreatment is effective in a proportion of cases., (© 2022 European Academy of Dermatology and Venereology.)
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- 2023
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12. Guselkumab effectiveness and survival in patients with psoriasis and psoriatic arthritis: Multicenter analysis in daily clinical practice by the Spanish Psoriasis Group.
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Rocamora V, Crespi L, Ferran M, Llamas-Velasco M, Del Alcázar E, Carrascosa JM, Beltran E, Urruticoechea-Arana A, Estebaranz JLL, Vidal D, Riera J, Rodríguez L, Armesto S, Fernández JM, Aparicio G, Pérez S, Porcar S, Montesinos E, and Gallardo F
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- Adult, Humans, Female, Middle Aged, Male, Retrospective Studies, Treatment Outcome, Severity of Illness Index, Arthritis, Psoriatic drug therapy, Psoriasis diagnosis, Psoriasis drug therapy
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Guselkumab is a monoclonal antibody that selectively blocks the p19 subunit of interleukin 23 and has been approved for the treatment of moderate to severe psoriasis and active psoriatic arthritis in adult patients due to its efficacy in different clinical trials. Therefore, itis important to know the performance of guselkumab in this setting of patients in clinical practice given that a high percentage of them are not represented in these clinical trials. Our objective was to evaluate the effectiveness and tolerability of guselkumab in clinical practice in the first patients with psoriasis and psoriatic arthritis treated since the date of its approval for psoriasis in Spain, in joint dermatology-rheumatology clinics. A multicenter retrospective data collection was carried out, in which 14 hospitals participated, including a total of 90 patients with psoriatic arthritis confirmed by a rheumatologist. Data collection was recorded at baseline and at weeks 12, 24, and 52 for both the articular and cutaneous domains. Ninety PsA patients started treatment with guselkumab and therefore were included in this study. The vast majority had already failed to at least to one biologic therapyprior guselkumab prescription. The median age was 55 years, 61% were female and 46% had a BMI ≥ 30 kg/m
2 . Sixty-nine percent suffered from peripheral arthritis, and in 34% an axial involvement was also detected; dactylitis or enthesitis was present in 24% and 29% of patients, respectively. Guselkumab was effective in controlling both articular and skin manifestations of PsA patients. Absolute PASI significantly decreased from 10.5 to 4.8, 1.9 and 1.3 at weeks 12, 24, and 52, respectively. In 29 out of 61 (48%) of cases, DAPSA was moderate or high, and patients showed a significant reduction in DAPSA at 12, 24, and 52 weeks of treatment (mean DAPSA values at baseline and follow up were 29, 20, 16, and 14, respectively). Patients with DAPSA in low activity or in remission at the time of initiation of guselkumab maintained response at the end of the study period. No new safety concerns were detected. Seventy-eight out of 90 patients (84.4%) persisted on treatment after 2 years follow-up. Our experience suggests that guselkumab isan effective drug for PsA and PsO patients in clinical practice with good tolerability and no additional safety signals, making it a new therapeutic alternative for the treatment of PsA and PsO patients., (© 2022 Wiley Periodicals LLC.)- Published
- 2022
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13. Hodgkin lymphoma with unusual cutaneous presentation.
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Romaní J, Gallardo F, Casulleras A, Martínez M, and Sáez A
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- Aged, Female, Hodgkin Disease therapy, Humans, Lymph Nodes surgery, Skin Neoplasms surgery, Groin pathology, Hodgkin Disease pathology, Lymph Nodes pathology, Skin Neoplasms pathology
- Published
- 2021
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14. An isotopic study of dietary diversity in formative period Ancachi/Quillagua, Atacama Desert, northern Chile.
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Pinder DM, Gallardo F, Cabello G, Torres-Rouff C, and Pestle WJ
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- Archaeology, Bone and Bones chemistry, Carbon Isotopes analysis, Chile, History, Ancient, Humans, Nitrogen Isotopes analysis, Collagen analysis, Diet history, Durapatite analysis, Indians, South American history
- Abstract
Objectives: To characterize the paleodiet of individuals from Formative Period (1500 B.C.-A.D. 400) Atacama Desert sites of Ancachi and Quillagua as a means of understanding the dietary and cultural impacts of regional systems of exchange., Materials and Methods: Thirty-one bone samples recovered from the cemetery of Ancachi (02QU175) and in/around the nearby town of Quillagua were the subject of carbon and nitrogen stable isotope analysis of bone collagen and hydroxyapatite and multisource mixture modeling (FRUITS, food reconstruction using isotopic transferred signals) of paleodiet. These individuals were compared with nearly 200 other Formative Period individuals from throughout the region to identify differences in dietary behaviors., Results: 80.6% (25/31) of the samples yielded sufficient well-preserved collagen and were included in the multisource mixture model. The FRUITS model, which compared individuals with a robust database of available foods from the region, identified a wide diversity of diets in the Ancachi/Quillagua area (including both coastal and interior individuals), and, most notably, thirteen individuals who consumed an average of 11.2 ± 1.9% terrestrial animals, 19.8 ± 1.9% legumes, and 22.5 ± 3.1% marine fauna, a balanced pattern of protein consumption distinct from both the coastal and inland individuals in our larger regional sample., Conclusions: The combination of stable isotope analysis and multisource mixture modeling permitted the characterization of dietary behavior of 25 individuals from nodal sites in the Atacama Desert, thus enhancing our understanding of the economic and social relationships that bound together Formative Period sites, populations, and individuals in this hyperarid region., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
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15. Anagen effluvium due to thallium poisoning derived from the intake of Chinese herbal medicine and rodenticide containing thallium salts.
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Curto-Barredo L, Segura S, Martín-Ezquerra G, Lloveras B, Gallardo F, and Pujol RM
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- Adult, Alopecia chemically induced, Child, Drugs, Chinese Herbal adverse effects, Female, Humans, Alopecia pathology, Hair pathology, Rodenticides poisoning, Thallium poisoning
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- 2015
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16. Lenalidomide-induced paronychia.
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Curto Barredo L, Salar A, Pujol RM, Garcia M, and Gallardo F
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- Adult, Female, Hodgkin Disease drug therapy, Humans, Lenalidomide, Thalidomide adverse effects, Angiogenesis Inhibitors adverse effects, Paronychia chemically induced, Thalidomide analogs & derivatives
- Published
- 2013
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17. Cutis laxa-like mycosis fungoides.
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López Aventín D, Gallardo F, Gil I, Martín-Ezquerra G, García M, Bellosillo B, Juanpere N, and Pujol RM
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- Aged, Diagnosis, Differential, Elastic Tissue pathology, Female, Humans, Mycosis Fungoides pathology, Skin Neoplasms pathology, Cutis Laxa diagnosis, Mycosis Fungoides diagnosis, Skin Neoplasms diagnosis
- Abstract
Mycosis fungoides is the most common form of primary cutaneous T-cell lymphoma. Several clinical and clinicopathological variants of mycosis fungoides have been reported. A 75-year-old woman presenting with multiple ill-defined areas of marked cutaneous wrinkling on the trunk and extremities is reported. Histopathological examination showed characteristic features of mycosis fungoides along with an interstitial dermal infiltrate composed predominantly of atypical lymphocytes with histiocytes intermingled within the collagen bundles. A focal reduction and fragmentation of elastic fibers was demonstrated. This observation illustrates a peculiar and previously unreported clinicopathological presentation of mycosis fungoides: cutis laxa-like mycosis fungoides, expanding the spectrum of mycosis fungoides variants associated with abnormalities of the dermal elastic fibers., (© 2012 Japanese Dermatological Association.)
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- 2012
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18. A small and active ring X chromosome in a female with features of Kabuki syndrome.
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Rodríguez L, Diego-Alvarez D, Lorda-Sanchez I, Gallardo FL, Martínez-Fernández ML, Arroyo-Muñoz ME, and Martínez-Frías ML
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- Child, Preschool, Comparative Genomic Hybridization, Craniofacial Abnormalities genetics, DNA Methylation, Diagnosis, Differential, Female, Humans, Limb Deformities, Congenital genetics, Mosaicism, Phenotype, RNA, Long Noncoding, RNA, Untranslated genetics, Syndrome, Turner Syndrome diagnosis, Turner Syndrome genetics, X Chromosome Inactivation, Abnormalities, Multiple genetics, Chromosomes, Human, X genetics, Ring Chromosomes
- Abstract
A ring X chromosome is found in about 6% of patients with Turner syndrome (TS), often with mosaicism for a 45,X cell line. Patients with this karyotype are reported to have a higher incidence of a more severe phenotype including mental retardation. In fact, some studies have shown a correlation between this severity and the presence or absence of an intact and functional X inactivation center (XIST). However, the phenotype of the individuals with r(X) cannot be entirely defined in terms of their X-inactivation patterns. Nevertheless, a small group of these patients have been described to manifest clinical features reminiscent of the Kabuki syndrome. Here we present a female patient with clinical features resembling Kabuki syndrome and a mos 45,X/46,X,r(X) karyotype. Methylation analyses of polymorphic alleles of the androgen receptor gene showed that both alleles were unmethylated suggesting an active ring chromosome. A specific X chromosome array CGH was performed estimating the size of the ring to be 17 Mb, lacking the XIST gene, and including some genes with possible implications in the phenotype of the patient., (Copyright 2008 Wiley-Liss, Inc.)
- Published
- 2008
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19. Peripheral T-cell lymphoma with secondary epithelioid granulomatous cutaneous involvement: a clinicopathologic study of four cases.
- Author
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Pujol RM, Gallardo F, Servitje O, Martí RM, Bordes R, García-Muret MP, Estrach MT, and Nomdedeu JF
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- Aged, Female, Granuloma pathology, Humans, Lymphoma, T-Cell, Peripheral pathology, Male, Middle Aged, Skin pathology, Skin Diseases pathology, Epithelioid Cells pathology, Granuloma complications, Lymphoma, T-Cell, Peripheral complications, Skin Diseases complications
- Abstract
Epithelioid granuloma formation has rarely been observed in specific cutaneous lesions from T-cell lymphomas other than those of mycosis fungoides/Sézary syndrome (MF/SS). Three patients diagnosed with nodal and/or extranodal (tonsillar) non-Hodgkin's peripheral T-cell lymphoma (PTCL) and one patient with angioimmunoblastic T-cell lymphoma (AILD), developed specific cutaneous involvement showing prominent epithelioid cell and/or granulomatous inflammation. The original diagnostic lesions had no granulomatous features. In addition to a specific lymphomatous infiltrate, prominent dermal and/or subcutaneous granulomatous infiltrates were observed. Sarcoid-like granulomas were observed in two patients (one of them presented a granuloma annulare-like pattern in early lesions), granulomatous panniculitis was noted in one patient and in one patient with AILD, masses of epithelioid cells were noted. The clinicopathological features of cutaneous involvement by PTCL showing a florid epithelioid and/or granulomatous cell reaction are reviewed. Various histopathological patterns can be observed. The diagnostic difficulties of these cases are stressed.
- Published
- 2005
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20. Increased resistance to quinolones in Campylobacter jejuni: a genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates.
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Ruiz J, Goñi P, Marco F, Gallardo F, Mirelis B, Jimenez De Anta T, and Vila J
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- Campylobacter Infections epidemiology, DNA Gyrase, Diarrhea epidemiology, Diarrhea microbiology, Drug Resistance, Microbial, Feces microbiology, Humans, Mutation, Spain epidemiology, Anti-Infective Agents pharmacology, Campylobacter Infections microbiology, Campylobacter jejuni drug effects, DNA Topoisomerases, Type II genetics, Quinolones pharmacology
- Abstract
Campylobacter jejuni is a frequent cause of enteritis and sometimes it requires antimicrobial therapy. We have studied the evolution of resistance to nine antibiotics from 1990 to 1994 and investigated how frequently gyrA mutations are involved in the acquisition of quinolone resistance. The percentage of chloramphenicol-, clindamycin-, tetracycline- and amoxicillin plus clavulanic acid-resistant strains has remained practically unchanged and erythromycin and gentamicin resistance has decreased, whereas the percentage of ampicillin-, nalidixic acid- or ciprofloxacin-resistant strains has almost doubled in the follow-up period, from 56 to 76% for ampicillin- and from 47.5 to 88% for quinolone-resistant strains. This study clearly shows that a mutation in Thr-86 to Ile or Lys is a frequent mechanism associated with the acquisition of a high level of resistance to quinolones in clinical isolates of C. jejuni.
- Published
- 1998
- Full Text
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