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Objective: The objective of this study was to assess how pre‐transplant dialysis duration affects transplant outcomes after simultaneous pancreas‐kidney transplant (SPK) in patients with type 1 diabetes mellitus (T1DM). Methods: Data of 6887 T1DM patients who underwent SPK transplantation between 2008 and 2018 were obtained from the Scientific Registry of Transplant Recipients database. According to pre‐transplant dialysis duration, the patients were divided into the preemptive SPK, 0‐2 years, 2‐5 years, and >5 years dialysis groups. Kaplan‐Meier survival analysis was performed to compare patient and graft survival among the groups. Univariate and multivariate Cox regression analyses were used to identify predictors of transplant outcomes. Results: The mean follow‐up period was 56.7 ± 34.7 months. Compared with no dialysis or preemptive SPK, dialysis for 0‐2 years was not significantly associated with patient or kidney graft survival, while long‐term dialysis of 2‐5 years and >5 years was significantly associated with increased risk of death and kidney graft failure. However, the duration of dialysis was not associated with pancreas graft survival. Conclusion: Long‐term dialysis duration before SPK transplant is an independent predictor of patient death and kidney graft failure in T1DM patients. [ABSTRACT FROM AUTHOR]

Background: There are no multicenter studies on the influence of diabetes duration on pancreatic transplant outcomes. Our study aimed to determine how type 1 diabetes duration influenced survival of pancreatic grafts. Methods: The data of 8,139 patients who received pancreas transplants during 2006–2015 were extracted from the Scientific Registry of Transplant Recipients database. Patients were separated into two groups according to duration of diabetes: S group (diabetes ≤20 years) and L group (>20 years). Results: Compared to S group, L group were older and prone to be male, to have higher body mass index, to receive pancreas after kidney transplantation (PAK), and to be White. Patient survival was not significantly different between the two groups, but pancreatic survival was better in the L group (hazard ratio 0.88; P = 0.012). Pancreatic survival of L group was better than S group in pancreas transplant alone and simultaneous pancreas‐kidney transplantation (SPK). Graft survival was not significant different between the two groups in PAK. Diabetes duration was an independent predictor of graft survival in SPK patients (hazard ratio 0.86; P = 0.012). Conclusions: Diabetes duration has no influence on patient survival. However, long duration of type 1 diabetes mellitus appears to be protective against pancreatic graft loss. [ABSTRACT FROM AUTHOR]