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To fully utilize the voltage regulation capacity and interaction characteristics of the Transmission and Distribution (T&D) system, a novel Modified Partially Observed Markov Decision Process (MPOMDP)‐based Reinforcement Learning (RL) scheme for Autonomous Voltage Control is proposed, which incorporates Demand Response (DR) and cooperation with the Transmission Network. The proposed scheme consists of two vital components: an MPOMDP block and a Modified Asynchronous Advantage Actor‐Critic‐based RL block. The MPOMDP block innovatively exploits the confidence interval of the observed state to make a better perception of the precise system state by introducing two new probability vectors. Then the MPOMDP block is fed into the underlying architecture of the RL block for asynchronously capturing features and optimal decision‐making, where the solving framework additionally brings in a public data buffer to realize boundary information sharing. Case studies are conducted on a modified T&D system considering N‐1 contingencies, with a training dataset from a district in Suzhou, China. Simulation results demonstrate that the proposed scheme can achieve significant voltage optimization while ensuring fast convergence speed. [ABSTRACT FROM AUTHOR]

Abstract: SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure‐function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed. [ABSTRACT FROM AUTHOR]