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Atomically thin, mechanically flexible, memory‐functional, and power‐generating crystals play a crucial role in the technological advancement of portable devices. However, the adoption of these crystals in such technologies is sometimes impeded by expensive and laborious synthesis methods, as well as the need for large‐scale, mechanically stable, and air‐stable materials. Here, an instant‐in‐air liquid metal printing process utilizing liquid bismuth (Bi) is presented, forming naturally occurring, air‐stable, atomically thin, mechanically flexible nanogenerators and ferroelectric oxides. Despite the centrosymmetric nature of the monoclinic P21/c system of achieved α‐Bi2O3‐δ the high kinetics of liquid metal synthesis leads to the formation of vacancies that disrupt the symmetry which is confirmed by density functional theory (DFT) calculations. The polarization switching is measured and utilized for ferroelectric nanopatterning. The exceptional attributes of these atomically thin multifunctional stable oxides, including piezoelectricity, mechanical flexibility, and polarizability, present significant opportunities for developing nano‐components that can be seamlessly integrated into a wide range of devices. [ABSTRACT FROM AUTHOR]

Liquid metal‐based printing techniques are emerging as an exemplary platform for harvesting non‐layered 2D materials with a thickness down to a few nanometres, leading to an ultra‐large surface‐area‐to‐volume ratio that is ideal for sensing applications. In this work, the synthesis of 2D tin dioxide (SnO2) by exfoliating the surface oxide of molten tin is reported which highlights the enhanced sensing capability of the obtained materials to ammonia (NH3) gas is reported. It is demonstrated that amperometric gas sensors based on liquid metal‐derived 2D SnO2 nanosheets can achieve excellent NH3 sensing performance at low temperature (150 °C) with and without UV light assistance. Detection over a wide range of NH3 concentrations (5–500 ppm) is observed, revealing a limit of detection at the parts per billion (ppb) level. The 2D SnO2 nanosheets also feature excellent cross‐interference performance toward different organic and inorganic gas species, showcasing a high selectivity. Further, ab initio DFT calculations reveal the NH3 adsorption mechanism is dominated by chemisorption with a charge transfer into 2D SnO2 nanosheets. In addition, a proof of concept for prototype flexible ammonia sensors is demonstrated by depositing 2D SnO2 on a polyimide substrate, signifying the high potential of employing liquid metal printed SnO2 for realizing wearable gas sensors. [ABSTRACT FROM AUTHOR]

Background: Postoperative sleep disorder (PSD) and delirium, which may be associated with surgery and inhalational anesthetics, induce adverse effects in old adults. Emerging evidence indicates that circadian rhythm contributes to various neuropathological diseases, including Alzheimer's disease. Thus, we analyzed the potential role of circadian rhythm in PSD and delirium‐like behavior in aged mice and determined whether exogenous melatonin could facilitate entrainment of the circadian rhythm after laparotomy under sevoflurane anesthesia. Methods: We selected old C57BL/6J mice which receiving laparotomy/sevoflurane anesthesia as model animals. We employed buried food, open field, and Y maze test to assess delirium‐like behavior, and electroencephalography/electromyography (EEG/EMG) were used to investigate sleep changes. We analyzed the transcription rhythm of clock genes in superchiasmatic nucleus (SCN) to explore the effects of surgery and melatonin pretreatment on the circadian rhythm. Then, we measured melatonin receptor levels in SCN and ERK/CREB pathway‐related proteins in hippocampus and prefrontal cortex to assess their role in PSDs and delirium‐like behavior. Results: Laparotomy under sevoflurane anesthesia had a greater influence than sevoflurane alone, leading to sleep disorder, a shift in sleep–wake rhythm, and delirium‐like behavior. Bmal1, Clock, and Cry1 mRNA expression showed a peak shift, MT1 melatonin receptor expression level was increased in the SCN, and p‐ERK/ERK and p‐CREB/CREB were decreased in hippocampus and prefrontal cortex of aged mice 1 day after laparotomy. Melatonin showed significant efficacy in ameliorating PSD and delirium‐like behavior and restoring the circadian rhythm, reversing melatonin receptor and ERK/CREB pathway expression abnormalities. In addition, most of the beneficial effect of melatonin was antagonized by luzindole, a melatonin receptor antagonist. Conclusions: Melatonin receptors in SCN, circadian rhythm, and ERK/CREB signaling pathway participate in the pathophysiological processes of PSD and delirium‐like behavior. Melatonin intervention could be a potential preventative approach for PSD and delirium. [ABSTRACT FROM AUTHOR]

Malignant hyperthermia (MH) is a potentially fatal inherited pharmacogenetic disorder related to pathogenic variants in the RYR1, CACNA1S, or STAC3 genes. Early recognition of the occurrence of MH and prompt medical treatment are indispensable to ensure a positive outcome. The purpose of this study was to provide valuable information for the early identification of MH by summarizing epidemiological and clinical features of MH. This scoping review followed the methodological framework recommended by Arksey and O'Malley. PubMed, Embase, and Web of science databases were searched for studies that evaluated the epidemical and clinical characteristics of MH. A total of 37 studies were included in this review, of which 26 were related to epidemiology and 24 were associated with clinical characteristics. The morbidity of MH varied from 0.18 per 100 000 to 3.9 per 100 000. The mortality was within the range of 0%–18.2%. Identified risk factors included sex, age, disorders associated with MH, and others. The most frequent initial clinical signs included hyperthermia, sinus tachycardia, and hypercarbia. The occurrence of certain signs, such as hypercapnia, delayed first temperature measurement, and peak temperature were associated with poor outcomes. The epidemiological and clinical features of MH varied considerably and some risk factors and typical clinical signs were identified. The main limitation of this review is that the treatment and management strategies were not assessed sufficiently due to limited information. [ABSTRACT FROM AUTHOR]

Introduction: Emerging evidence suggests that mitochondrial dysfunction plays a crucial role in the pathogenesis of postoperative delayed neurocognitive recovery (dNCR). Mitochondria exist in a dynamic equilibrium that involves fission and fusion to regulate morphology and maintains normal cell function via the removal of damaged mitochondria through mitophagy. Nonetheless, the relationship between mitochondrial morphology and mitophagy, and how they influence mitochondrial function in the development of postoperative dNCR, remains poorly understood. Here, we observed morphological alterations of mitochondria and mitophagy activity in hippocampal neurons and assessed the involvement of their interaction in dNCR following general anesthesia and surgical stress in aged rats. Methods: Firstly, we evaluated the spatial learning and memory ability of the aged rats after anesthesia/surgery. Hippocampal mitochondrial function and mitochondrial morphology were detected. Afterwards, mitochondrial fission was inhibited by Mdivi‐1 and siDrp1 in vivo and in vitro separately. We then detected mitophagy and mitochondrial function. Finally, we used rapamycin to activate mitophagy and observed mitochondrial morphology and mitochondrial function. Results: Surgery impaired hippocampal‐dependent spatial learning and memory ability and caused mitochondrial dysfunction. It also increased mitochondrial fission and inhibited mitophagy in hippocampal neurons. Mdivi‐1 improved mitophagy and learning and memory ability of aged rats by inhibiting mitochondrial fission. Knocking down Drp1 by siDrp1 also improved mitophagy and mitochondrial function. Meanwhile, rapamycin inhibited excessive mitochondrial fission and improved mitochondrial function. Conclusion: Surgery simultaneously increases mitochondrial fission and inhibits mitophagy activity. Mechanistically, mitochondrial fission/fusion and mitophagy activity interact reciprocally with each other and are both involved in postoperative dNCR. These mitochondrial events after surgical stress may provide novel targets and modalities for therapeutic intervention in postoperative dNCR. [ABSTRACT FROM AUTHOR]

Low‐intensity ultrasound (LI‐US) is a non‐invasive stimulation technique that has emerged in recent years and has been shown to have positive effects on neuromodulation, fracture healing, inflammation improvement, and metabolic regulation. This study reports the conclusions of a bibliometric analysis of LI‐US. Input data for the period between 1995 and 2022, including 7209 related articles in the field of LI‐US, were collected from the core library of the Web of Science (WOS) database. Using these data, a set of bibliometric indicators was obtained to gain knowledge on different aspects: global production, research areas, and sources analysis, contributions of countries and institutions, author analysis, citation analysis, and keyword analysis. This study combined the data analysis capabilities provided by the WOS database, making use of two bibliometric software tools: R software and VOS viewer to achieve analysis and data exploration visualization, and predicted the further development trends of LI‐US. It turns out that the United States and China are co‐leaders while Zhang ZG is the most significant author in LI‐US. In the future, the hot spots of LI‐US will continue to focus on parameter research, mechanism discussion, safety regulations, and neuromodulation applications. [ABSTRACT FROM AUTHOR]

Miniaturization and energy consumption by computational systems remain major challenges to address. Optoelectronics based synaptic and light sensing provide an exciting platform for neuromorphic processing and vision applications offering several advantages. It is highly desirable to achieve single‐element image sensors that allow reception of information and execution of in‐memory computing processes while maintaining memory for much longer durations without the need for frequent electrical or optical rehearsals. In this work, ultra‐thin (<3 nm) doped indium oxide (In2O3) layers are engineered to demonstrate a monolithic two‐terminal ultraviolet (UV) sensing and processing system with long optical state retention operating at 50 mV. This endows features of several conductance states within the persistent photocurrent window that are harnessed to show learning capabilities and significantly reduce the number of rehearsals. The atomically thin sheets are implemented as a focal plane array (FPA) for UV spectrum based proof‐of‐concept vision system capable of pattern recognition and memorization required for imaging and detection applications. This integrated light sensing and memory system is deployed to illustrate capabilities for real‐time, in‐sensor memorization, and recognition tasks. This study provides an important template to engineer miniaturized and low operating voltage neuromorphic platforms across the light spectrum based on application demand. [ABSTRACT FROM AUTHOR]

Thin film transistors (TFTs) are key components for the fabrication of electronic and optoelectronic devices, resulting in a push for the wider exploration of semiconducting materials and cost‐effective synthesis processes. In this report, a simple approach is proposed to achieve 2‐nm‐thick indium oxide nanosheets from liquid metal surfaces by employing a squeeze printing technique and thermal annealing at 250 °C in air. The resulting materials exhibit a high degree of transparency (>99 %) and an excellent electron mobility of ≈96 cm2 V−1 s−1, surpassing that of pristine printed 2D In2O3 and many other reported 2D semiconductors. UV‐detectors based on annealed 2D In2O3 also benefit from this process step, with the photoresponsivity reaching 5.2 × 104 and 9.4 × 103 A W−1 at the wavelengths of 285 and 365 nm, respectively. These values are an order of magnitude higher than for as‐synthesized 2D In2O3. Utilizing transmission electron microscopy with in situ annealing, it is demonstrated that the improvement in device performances is due to nanostructural changes within the oxide layers during annealing process. This work highlights a facile and ambient air compatible method for fabricating high‐quality semiconducting oxides, which will find application in emerging transparent electronics and optoelectronics. [ABSTRACT FROM AUTHOR]

Developing mixed‐anion semiconductors for solar fuel production has inspired extensive interest, but the nitrohalide‐based photocatalyst is still in shortage. Here we report a layered nitro‐halide β‐ZrNBr with a narrow band gap of ca. 2.3 eV and low defect density to exhibit multifunctionalities for photocatalytic water reduction, water oxidation and CO2 reduction under visible‐light irradiation. As confirmed by the results of electron paramagnetic resonance (EPR) and density functional theory (DFT) calculations, the formation of anion vacancies in the nitro‐halide photocatalyst was inhibited due to its relatively high formation energy. Furthermore, performance of β‐ZrNBr can be effectively promoted by a simple exfoliation into nanosheets to shorten the carrier transfer distance as well as to promote charge separation. Our work extends the territory of functional photocatalysts into the nitro‐halide, which opens a new avenue for fabricating efficient artificial photosynthesis. [ABSTRACT FROM AUTHOR]

Wide bandgap semiconducting oxides are emerging as potential 2D materials for transparent electronics and optoelectronics. This fuels the quest for discovering new 2D metal oxides with ultrahigh transparency and high mobility. While the former can be achieved by reducing the thickness of oxide films to only a few nanometers, the latter is more commonly realized by intentional doping. This article reports a one‐step synthesis of few‐unit‐cell‐thick and laterally large antimony‐doped indium oxide (IAO). The doping process occurs spontaneously when the oxide is grown on the surface of a molten Sb–In alloy and 2D IAO nanosheets can be easily printed onto desired substrates. With thicknesses at the atomic scale, these materials exhibit excellent transparency exceeding 98% across the visible and near‐infrared range. Field‐effect transistors based on low‐doped IAO nanosheets reveal a high electron mobility of ≈40 cm2 V−1 s−1. Additionally, a notable photoresponse is observed in 2D IAO‐based photodetectors under ultraviolet (UV) radiation. Photoresponsivities of low‐doped and highly doped IAO at a wavelength of 285 nm are found to be 1.2 × 103 and 0.7 × 103 A W−1, respectively, identifying these materials as promising candidates for the fabrication of high‐performance optoelectronics in the UV region. [ABSTRACT FROM AUTHOR]

Aims: Delayed neurocognitive recovery (dNCR) is a common postoperative complication in geriatric surgical patients for which there is no efficacious therapy. Cholecystokinin octapeptide (CCK‐8), an immunomodulatory peptide, regulates memory and learning. Here, we explored the effects and mechanism of action of CCK‐8 on dNCR. Methods: We applied laparotomy to establish a model of dNCR in aged mice. Morris water maze and fear conditioning tests were used to evaluate cognition. Immunofluorescence was used to detect the density of CCK‐8, A1 reactive astrocytes, glutamatergic synapses, and activation of microglia in the hippocampus. Quantitative PCR was performed to determine mRNA levels of synapse‐associated factors. A1 reactive astrocytes, activated microglia, and glutamatergic synapse‐associated protein levels in the hippocampus were assessed by western blotting. Results: Administration of CCK‐8 suppressed the activation of microglia, the induction of A1 reactive astrocytes, and the expression of tumor necrosis factor alpha, complement 1q, and interleukin 1 alpha in the hippocampus. Furthermore, it promoted glutamatergic synaptogenesis and neurocognitive recovery in aged dNCR model mice. Conclusion: Our findings indicated that CCK‐8 alleviated cognitive impairment and promoted glutamatergic synaptogenesis by inhibiting the induction of A1 reactive astrocytes and the activation of microglia. CCK‐8 is, therefore, a potential therapeutic target for dNCR. [ABSTRACT FROM AUTHOR]

Post‐operative sleep disorders induce adverse effects on patients, especially the elderly, which may be associated with surgery and inhalational anaesthetics. Melatonin is a neuroendocrine regulator of the sleep‐wake cycle. In this study, we analysed the alterations of post‐operative sleep in aged melatonin‐deficient (C57BL/6J) mice, and investigated if exogenous melatonin could facilitate entrainment of circadian rhythm after laparotomy under sevoflurane anaesthesia. The results showed that laparotomy under sevoflurane anaesthesia had a greater influence on post‐operative sleep than sevoflurane alone. Laparotomy under anaesthesia led to circadian rhythm shifting forward, altered EEG power density and delta power of NREM sleep, and lengthened REM and NREM sleep latencies. In the light phase, the number of waking episodes tended to decline, and wake episode duration elevated. However, these indicators presented the opposite tendency during the dark phase. Melatonin showed significant efficacy for ameliorating the sleep disorder and restoring physiological sleep, and most of the beneficial effect of melatonin was antagonized by luzindole, a melatonin receptor antagonist. [ABSTRACT FROM AUTHOR]

Lidocaine, one of the most commonly used local anesthetics during surgery, has been reported to suppress cancer cell growth via blocking voltage‐gated sodium channels (VGSCs). VGSC 1.5 (NaV1.5) is highly expressed in invasive cancers including ovarian cancer. This study aims to investigate whether lidocaine inhibits the malignancy of ovarian cancer through NaV1.5 blockage. Human ovarian cancer, its metastatic cancer and normal ovarian tissues were probed with anti‐NaV1.5 antibody in situ. Human ovarian cancer A2780 and SKOV3 cells were cultured and their growth, epithelial‐mesenchymal transition (EMT), migration, and invasion in the presence or absence of lidocaine together with underlying molecular mechanisms were assessed. Murine syngeneic ovarian cancer (ID8) model was also used to determine the chemotherapeutic efficiency of cisplatin in combination with lidocaine. The high level of NaV1.5 expression was found in human ovarian cancer and even higher in its metastatic cancer but not in normal ovarian tissues. Lidocaine decreased the growth, EMT, migration, and invasion of human ovarian cancer A2780 and SKOV3 cells. Lidocaine enhanced the chemotherapeutic efficiency of cisplatin in both ovarian cancer cell cultures and a murine ovarian metastatic model. Furthermore, a downregulation of NaV1.5 by siRNA transfection, or FAK inhibitor application, inhibited the malignant properties of SKOV3 cells through inactivating FAK/Paxillin signaling pathway. Our data may indicate that lidocaine suppresses the metastasis of ovarian cancer and sensitizes cisplatin through blocking NaV1.5‐mediated EMT and FAK/paxillin signaling pathway. The translational value of lidocaine local application as an ovarian cancer adjuvant treatment warrants further study. [ABSTRACT FROM AUTHOR]

Suwan germplasm plays important roles in maize breeding in tropical/subtropical regions, especially in southern China. To analyze the genetic characteristics of Suwan maize germplasm, one panel of 73 lines derived from the Suwan population and temperate resources were collected and genotyped using 56,110 single‐nucleotide polymorphism (SNP) markers. The results revealed four subgroups, namely, QR273, Ki32, HCL645, and PH4CV, with an average genetic distance of 0.304, varying from 0.001 to 0.370. In addition, many identical‐by‐descent (IBD) segments were found among Suwan germplasms and their descendants, of which 78 segments were detected only in the QR273 subgroup, 18 segments were detected only in the Ki32 subgroup, 53 and 11 segments were detected only in the PH4CV and the HCL645 subgroup, respectively. Pairwise comparisons showed that 13 segments were common between the QR273 and Ki32 subgroups, 5 segments were common between the QR273 and HCL645 subgroups, 26 segments were common between the QR273 and PH4CV subgroups. Five and 14 segments were common between the Ki32 versus HCL645 subgroups and Ki32 versus PH4CV subgroups. Three segments were commonly detected in the Ki32, QR273, and HCL645 subgroups. Candidate gene analysis showed that 132 genes were located in these segments, wherein seven new candidate genes were associated with flower time (FT)‐related traits, which were located in the IBD segments of QR273 or HCL645. Zm00001d033130_T005 and Zm00001d013768_T001 were located in the IBD segments specific to the QR273 subgroup. These two genes function in cell differentiation and flower development and would be very important for the phenotypic variations of the given FP subgroups. These results provide new insights and scientific proof for dissecting the genetic basis of complex traits and the utilization of Suwan germplasm in future maize breeding. [ABSTRACT FROM AUTHOR]

The frequency stability in the sending-end network with renewable energy generating units should be paid attention especially for an asynchronous interconnection system. When the DC blocking fault occurs in the system, the problem of high frequency in the sending-end network can be suppressed by using the frequency limit controller (FLC). This study introduces the structure and the parameters tuning method of the FLC, and the parameters optimisation method is proposed to avoid FLC acting repeatedly. In the study, a case is studied, and the results show that the FLC is important in the sending-end network. Finally, aiming at the coordination problem between multiple FLCs, a control strategy based on FLC influence coefficient is proposed in the study, and the strategy can suppress the over regulation effectively. [ABSTRACT FROM AUTHOR]

The asynchronous connection by high-voltage direct current (HVDC) links optimises the power angle stability of the large area power grid. However on the side of the sending-end, the loss of DC links causes high frequency, of which the frequency deviation peak is an important index in the study of the power grid frequency stability. In this study, the method to calculate the peak value of frequency deviation based on the change rate of the frequency deviation is obtained by analysing a single-machine system. Then, the application of method is extended to the actual power system to study HVDC additional control and generator tripping. Finally, the single-machine power grid and Yunnan Power Grid are simulated, respectively, to verify the accuracy and the feasibility of the method. The simulation results show that the method is accurate and applicable to the actual power grid, which has practical value of engineering. [ABSTRACT FROM AUTHOR]

Melatonin exerts many physiological effects via melatonin receptors, among which the melatonin-2 receptor ( MT2) plays a critical role in circadian rhythm disorders, Alzheimer's disease and other neurological disorders. A melatonin replacement strategy has been tested previously, and MT2 was a critical target during the process. cAMP response element binding ( CREB) is an essential transcription factor for memory formation and could be involved in MT2 signalling. Therefore, the present study was designed to investigate the effects of prophylactic melatonin on inhaled anaesthetic isoflurane-induced cognitive impairment, and to determine whether the protective effects of melatonin are dependent on MT2 and downstream CREB signalling in the hippocampus of aged rats. The results showed that prophylactic melatonin attenuated isoflurane-induced decreases in plasma/hippocampal melatonin levels and cognitive impairment in aged rats. Furthermore, 4P- PDOT, a selective MT2 antagonist, blocked the protective effects of melatonin on isoflurane-induced decreases in both hippocampal MT2 expression and downstream CREB phosphorylation. And 4P- PDOT blocked the attenuation of melatonin on isoflurane-induced memory impairment. Collectively, the results suggest that the protective effects of prophylactic melatonin are dependent on hippocampal MT2- CREB signalling, which could be a potential therapeutic target for anaesthetic-induced cognitive impairment. [ABSTRACT FROM AUTHOR]

Hypoxia-inducible factor (HIF)-1 is the key transcriptional activator mediating both adaptive and pathological responses to hypoxia. The purpose of this study was to find the role of HIF-1 in regulating neprilysin (NEP) at the early stage of hypoxia and explore the underlying mechanism. In this study, we demonstrated that both NEP mRNA and protein levels in neuroblastoma cells were elevated in early stages of hypoxia. Over-expression of HIF-1α gene increased NEP mRNA/protein levels, as well as enzyme activity while knockdown of HIF-1α decreased them. Meanwhile, HIF-1α was shown to bind to histone deacetylase (HDAC)-1 and reduced the association of HDAC-1 with NEP promoter, thus activating NEP gene transcription in a de-repression way. In summary, our results indicated that hypoxia in the early stages would up-regulate NEP expression, in which interaction of HIF-1α and HDAC-1 may play a role. This study suggested that NEP up-regulation might be an adaptive response to hypoxia, which was mediated by HIF-1α binding to HDAC-1 at the early stage of hypoxia. [ABSTRACT FROM AUTHOR]

In this study, microwave-assisted extraction with ethanol ( MAEE) of star anise oil from Illicium verum Hook.f. has been optimised by response surface methodology ( RSM). A maximum yield of star anise oil was obtained at an optimum condition: the ratio of solvent to sample 17 mL g−1, extraction time 16 min and microwave power 505 W. Accordingly, the highest yield of star anise oil was about 24.98%, which was much higher than that of steam distillation ( SD), 7.17%. Oxygenated organic compounds in representative of trans-anethole are a major component in star anise oil, nearly 94.21% for SD and 86.66% for MAEE, identified and determined by GC- MS. The oils extracted by SD and MAEE both have strong antioxidant activities that were demonstrated by the DPPH and ABTS assays. [ABSTRACT FROM AUTHOR]

Melatonin is an endogenous hormone with neuroprotective effects. Melatonin levels in elderly patients are reduced after surgeries that require anaesthesia. Whether reduced melatonin levels are important for postoperative cognitive dysfunction ( POCD) remains unclear. Here, we investigated the effects of melatonin on cognitive dysfunctions induced by isoflurane and mechanisms underlying these effects. Seventy-two 20-month-old Sprague-Dawley rats were randomly divided into six groups (n = 12). These groups included M1 and M10 groups that received intraperitoneal melatonin at 1 mg/kg or 10 mg/kg, respectively, and an ISO group that received 4 hr of inhaled 2% isoflurane. They also included M1+ ISO and M10+ ISO groups that received 1 mg/kg or 10 mg/kg of melatonin plus 4 hr of inhaled 2% isoflurane, respectively, and a control group that received an equal volume of saline. Injections were administered daily for 14 consecutive days. Memory was assessed in the Morris water maze. Plasma and hippocampi were harvested to determine melatonin concentrations and MT1/ MT2 receptor expression. Rats treated only with isoflurane showed significantly longer latencies in Morris water maze test trials compared with the control group, with shorter time in the probe trial ( p < 0.05). Although plasma melatonin levels and MT2 expression in the hippocampus were significantly decreased, MT1 expression was higher in the isoflurane group than in the control group ( p < 0.001). However, these parameters did not significantly vary in animals administered melatonin compared with controls. Isoflurane may induce cognitive dysfunction by influencing melatonin and MT1/ MT2 levels. Melatonin can improve cognitive dysfunction by normalizing plasma melatonin and its receptor levels. [ABSTRACT FROM AUTHOR]

The key issue in utilizing solid polymer electrolytes for high‐energy‐density lithium metal batteries is to balance the conflicting demands of superior processability, adequate ionic conductivity, and mechanical stability. Inspired by molecular structure design, a metal‐organic framework‐derived polyether poly(urethane urea) solid polymer electrolyte (denoted as ePU@H SPE) has been synthesized via a facile polycondensation method involving covalent crosslinking. The reduced crystallinity and numerous polar groups in ePU@H SPEs enhance Li salt dissociation and create efficient Li+ ion diffusion channels, yielding remarkable ionic conductivity (1.48 × 10−4 S cm−1). The polymer backbones, incorporating covalent bonds and dynamic hydrogen bonds, provide superb mechanical strength (5.12 GPa), high toughness (1240%), and excellent resilience, which suppress lithium dendrite growth and buffer electrode volume fluctuations during cycling. Leveraging these attributes, the well‐designed ePU@H SPE enables ultra‐high durability in lithium plating/stripping over 2300 h. Moreover, the integrated LFP|ePU@H|Li batteries, generating delicate electrode/electrolyte interfacial contact, deliver an exceptionally long lifespan (86% retention over 500 cycles at 1 C). Moreover, the LFP|ePU@H|Li pouch cell operates reliably even under severe deformation and external damage. Impressively, the stable cycling performance of full batteries incorporating high‐voltage LCO and high‐capacity S cathodes further verifies the significant potential of advanced ePU@H SPEs for practical applications. [ABSTRACT FROM AUTHOR]