Search

Objective: To determine the median survival time (MST) of dogs with nasal carcinoma treated with toceranib phosphate. Material and methods: The databases of four Spanish referral hospitals were retrospectively searched for dogs with a diagnosis of nasal tumours presented between January 2015 and October 2020. Dogs treated with radiotherapy or other chemotherapies prior toceranib were excluded. Results: Twenty‐three dogs with a confirmed nasal carcinoma treated with toceranib phosphate and with a CT scan for initial staging according to Adams Modified Staging System were included. Nine dogs had a stage III nasal carcinoma whereas 14 dogs had a stage IV nasal carcinoma. No dog had stages I and II nasal carcinoma. The median overall survival time was 139 days. The difference between the MST between dogs with stages III and IV was not statistically significant [P = 0.6, 140 days for stage III (range 46–401) vs 120 days for stage IV (range 23–600)]. Overall, dogs with epistaxis achieved a longer median survival (166 days) than dogs without epistaxis (83 days). Toceranib phosphate was generally well tolerated. Most dogs had an initial clinical benefit followed by progressive disease. Significance: This is the first study to report the MST in dogs with stages III and IV nasal carcinoma treated with toceranib phosphate. This retrospective study showed that toceranib phosphate decreases the clinical signs associated with nasal carcinomas. [ABSTRACT FROM AUTHOR]

Naturally occurring populations of most species are distributed non‐uniformly across their ranges. Observed changes in range‐wide population size are attributed to local‐scale processes such as fecundity and survival and to regional scale demographic processes such as immigration. It is often infeasible to study a species across its entire range, and we frequently make inferences on populations as a whole based on the demographic rates of a more restricted area. Extrapolating inferences about demographic processes from study areas to the entire species' range can lead to erroneous estimations, particularly when permanent emigrants contribute significantly to individual population processes. In this paper, we evaluated demographic processes and population trends at multiple scales for tricolored blackbirds (Agelaiustricolor) in California using site‐specific banding data and range‐wide citizen‐science data. First, we found that a previous estimate of statewide decline of 34% is largely driven by an estimated decline of 51.7% for the southern population. Second, we found evidence of a pseudo‐source and sink system, with the northern region acting as a sink for individuals moving from the declining southern region. The southern region is a "pseudo‐source" since it has lower rates of adult survival and an annual growth rate of r = −0.099, while still acting as a source of immigrants for the northern region. In turn, the north fits the traditional definition of a sink by an annual growth rate near zero, in addition to declining at a rate of 2.5% even though it is estimated to receive immigrants from the south at rates ranging from 8.3% to 13.2% per year. Our results suggest that the loss of wetland habitats in Southern California, coupled with increasing severity of droughts driven by changing climatic conditions, has created this pseudo‐source and sink system. Long term, tricolored blackbirds are likely to experience range contraction in the south, and the northern region is likely to undergo declines due to a loss of immigrants from the south. [ABSTRACT FROM AUTHOR]

Population genetic analyses based on both mitochondrial cytochrome b and the internal transcribed spacer 2 of recombinant (r)DNA genes were implemented to examine hypotheses of population differentiation in the angular angel shark Squatina guggenheim, one of the four most-widespread endemic species inhabiting coastal ecosystems in the south-western Atlantic Ocean. A total of 82 individuals of S. guggenheim from 10 sampling sites throughout the Río de la Plata mouth, its maritime front, the outer shelf at the subtropical confluence and the coastal areas of the south-west Atlantic Ocean, were included. The analysis of molecular variance ( AMOVA) based on the second internal transcribed spacer ( its-2) region supports that the samples from the outer shelf represent an isolated group from other sites. Historical gene flow in a coalescent-based approach revealed significant immigration and emigration asymmetry between sampling sites. Based on the low level of genetic diversity, the existence of a long-term population decline or a past recent population expansion following a population bottleneck could be proposed in S. guggenheim. This demographic differentiation suggests a degree of vulnerability to overexploitation in this endemic and endangered south-west Atlantic Ocean shark, given its longevity and low reproductive potential. [ABSTRACT FROM AUTHOR]

Background Topical retinoids have been successfully used in the treatment of acne vulgaris but may induce irritation when used twice daily. The association of retinaldehyde (RAL) with glycolic acid (GA) have complementary activities, which could be of interest for adult women with acne because of a better tolerance/efficacy ratio. The aim of this study was to evaluate the tolerance and the efficiency of RAL (0.1%)/GA (6%) in adult women with acne when used alone or in combination with their usual acne products except retinoids. Methods Three hundred ninety-seven women with acne (aged between 30 and 40 years old) were included in this open multicentric study. They had to apply cream containing RAL/GA for 90 days without stopping their previous acne treatment (except topical retinoids). The tolerance was the main criteria and the second one is the efficacy, which was assessed by counting inflammatory and retentional lesions after 30 and 90 days of treatment. Results Used alone or in association with other anti-acne treatments, RAL/GA was considered to be highly tolerated. A significant decrease in both inflammatory and retentional lesions between day 0 and day 90 indicates that RAL/GA can be used as monotherapy for mild acne or could potentate the efficiency of other anti-acne products used at the same time by patients suffering from moderate acne. Complaints about side-effects were rare. The subjective evaluation of the preparation's efficacy by investigators and patients was strongly favourable. Conclusion These data show that a combination of RAL 0.1% and GA 6% may be used in association with other topical anti-acne treatments with an excellent tolerance. Conflicts of interest None declared [ABSTRACT FROM AUTHOR]

Background and purpose:The present study investigated the mechanisms by which oleanolic acid, a component of olive oil, increases release of nitric oxide (NO).Experimental approach:Measurements of isometric tension, NO concentration, or endothelial cell calcium were made in rat isolated mesenteric arteries. Immunoblotting for endothelial NOS (eNOS) and Akt kinase were performed in primary cultures of human umbilical vein endothelial cells (HUVECs).Key results:Oleanolic acid (3–30 μM) evoked endothelium-dependent relaxations in noradrenaline-contracted rat superior and small mesenteric arteries. In rat superior mesenteric arteries, oleanolic acid induced simultaneous increases in NO concentration and relaxation, and these responses were inhibited by an inhibitor of NOS, asymmetric dimethyl-L-arginine (300 μM) and by the NO scavenger, oxyhaemoglobin (10 μM). Oleanolic acid-evoked NO increases were not reduced in Ca2+-free solution and in the presence of an inhibitor of endoplasmic reticulum calcium-ATPase, thapsigargin (1 μM). Oleanolic acid evoked relaxation without changes in endothelial cell calcium, but decreased smooth muscle calcium in arterial segments. Oleanolic acid failed to increase calcium in HUVECs, but increased time-dependently phosphorylation of Akt kinase at Serine473 (Akt-Ser473) and eNOS at Serine1177 (eNOS-Ser1177), which was attenuated by inhibitors of phosphoinositide-3-kinase.Conclusions and implications:This study provides direct evidence that a component of olive oil, oleanolic acid, activated endothelium-dependent release of NO and decreased smooth muscle cell calcium followed by relaxation. The oleanolic acid-evoked endothelium-derived NO release was independent of endothelial cell calcium and involved phosphoinositide-3-kinase-dependent phosphorylation of Akt-Ser473 followed by phosphorylation of eNOS-Ser1177.British Journal of Pharmacology (2008) 155, 535–546; doi:10.1038/bjp.2008.289; published online 14 July 2008 [ABSTRACT FROM AUTHOR]

Caecal and colonic uptake of both linoleic acid and cholesterol were studied in rats after distal small bowel resection (DSBR). The results showed that the surgical operation increased the caecal and colonic uptake of linoleic acid. Supplementation with linolenic acid inhibited caecal and colonic uptake of linoleic acid. Experiments carried out in the presence of rotenone and ouabain suggest that facilitated diffusion is the predominant mechanism of caecal and colonic linoleic acid absorption, at least at low concentrations. An increase in caecal and colonic uptake of cholesterol was observed after the surgical operation. The study showed that facilitated diffusion seems to be the mechanism of linoleic acid absorption in the caecum and colon, and that both organ growth and changes in transport function of the epithelial cells of caecum and colon appear to be involved in the adaptive response of the bowel to intestinal resection. [ABSTRACT FROM AUTHOR]

We have studied the activities of Δ9, Δ6 and Δ5 desaturases in rat liver and jejunum when the entero-hepatic circulation was interrupted by either 50 or 75% intestinal resection. Desaturase activities in caecal mucosa were also determined in control and operated rats. Distal small bowel resection significantly altered the activities of desaturase enzymes in liver, jejunum and caecum. Thus, the Δ9 desaturase activity was lower in hepatic microsomes from operated animals, and this decrease was not related to the extent by which the intestine was removed. However, a significant increase in both Δ6 and Δ5 desaturases was found in these animals compared to shamoperated rats, the increase in both desaturases being higher after 75% than after 50% intestinal resection. The activities of Δ9 and Δ5 desaturases were significantly increased in jejunal mucosa of resected rats. The activity of Δ6 desaturase was increased only in 50% resected-animals. An increase in Δ6 desaturase activity was observed in caecal mucosa after resection, together with a decrease in Δ9 desaturase and no change in Δ5 desaturase activities. Enzyme activities were highest in the liver relative to the activity in jejunal and caecal homogenates. In sham rats, the caecal mucosa showed higher Δ9 and Δ6 but lower Δ5 desaturase activities than in jejunal mucosa. [ABSTRACT FROM AUTHOR]

This technique report describes a fully digital workflow in which two surgical guides (i.e. one for alveolar bone reduction and the other for implant placement) are magnetically connected to ensure stability during full-arch implant surgery following guided bone reduction. Digital prosthesis design as well as virtual bone reduction and implant planning are developed from the superimposition of facial, intraoral and CBCT scans. With this technique, different surgical guides and interim poly(methylmethacrylate) (PMMA) fixed prosthesis are precisely connected with magnets after being digitally designed and 3D-printed. As a result, such magnetic connection allows for satisfactory stability of the implant surgical guide, as well as of the interim fixed PMMA fixed prosthesis during capture of screw-retained abutments., (© 2020 by the American College of Prosthodontists.)