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Objectives: The aim of this systematic review was to assess the oral health‐related quality of life (OHRQoL) of patients with osteoarthritis (OA) of the temporomandibular joint (TMJ). Methods: This systematic literature search applied the search terms "oral health‐related quality of life AND osteoarthritis of jaw OR arthritis of temporomandibular joint AND oral health‐related quality of life" in PubMed, Medline, Web of Science and Scopus. Eligibility criteria were publication until 31 August 2021, examination of children or adults with OA of TMJ, reporting of any OHRQoL measurement and a full text in English language. Two different, independent and experienced reviewers performed this systematic literature search. The analysis of respective data was qualitative. For quality appraisal, the available checklist from the Agency for Healthcare Research and Quality (AHRQ) was applied. Results: Out of 102 findings, eight studies were included in qualitative analysis. Seven clinical investigations were performed in adults aged between 34 and 43 years. The other included study was performed on children. The quality of two studies was moderate, and six studies were evaluated as of high quality. Most studies applied the 14‐item short form of the oral health impact profile (OHIP 14) for assessment of OHRQoL. OHIP 14 ranged between 9.24 and 38.86 points in means of sum score. Comparison with healthy individuals revealed worse OHRQoL of OA patients in two studies. Associations between OHRQoL with either oral health, general quality of life or disease‐related parameters were rarely reported and heterogeneous. Five of the included studies reported subscales of OHIP 14, showing an impairment in all subscales. Conclusions: There are hints that patients with OA of the TMJ show a reduced OHRQoL. More studies are needed, especially regarding oral health, disease‐related parameters and pain intensity and its potential influence on OHRQoL. [ABSTRACT FROM AUTHOR]

Summary: Background: Erosive tooth wear (ETW) has become a crucial oral health problem over the decades in China. Objectives: To explore the prevalence and risk indicators of ETW among adolescents in Guangzhou, south China. Methods: A cross‐sectional survey of 720 participants was conducted in Guangzhou, using an equal‐sized, stratified, multistage random sampling approach. The participants were from two different age groups (12‐ and 15‐year‐olds), 360 per group. The ratio of males to females was 1:1 in each group. ETW was recorded utilising the basic erosive wear examination (BEWE) index as the dependent variable. Independent variables included age, gender, region, socioeconomic status, dietary factors, oral health measures and others. Results: The prevalence rates (weighted) of ETW and dentin exposure (DE) were 56.1% and 26.2% among adolescents in Guangzhou, with mean teeth (weighted) of 1.8 ± 2.5 and 0.6 ± 1.5, respectively. No matter the prevalence or the mean teeth, the 15‐year‐olds were higher than the 12‐year‐olds; the mean teeth of ETW of males was higher than that of females; the mean teeth of ETW and DE of the adolescents of low socioeconomic status were higher than those of high socioeconomic status. Medium to high risk levels were found for 10.1%. In the multiple regression model, age, gender and taking acidic foods/drinks before sleep were associated with ETW. Conclusions: Moderate ETW in the permanent dentition was common among adolescents in Guangzhou. However, the teeth involved were low. Dietary factors and demographics were the main risk indicators. [ABSTRACT FROM AUTHOR]

The role of B cells in the generation of cancer-immune tolerance is unclear. This study aims to investigate the role of cancer-derived microvesicles (Mvcs) in the generation of transforming growth factor (TGF)-β+ B cells. In this study, esophageal cancer (Eca) cells were isolated from surgically removed cancer tissue. Mvcs were purified from the culture supernatant and characterized by Western blotting. The immune suppression assay was carried out with a cell culture model and flow cytometry. The results showed that Eca-derived Mvcs were LAMP1 positive and carried MMP9. Exposure to the Mvcs induces naive B cells to differentiate into TGF-β-producing regulatory B cells; the latter show immune suppressor functions on CD8+ T-cell proliferation. In conclusion, Eca-derived Mvc can induce TGF-β+ B cells; the latter suppress CD8+ T-cell activities. The MMP9-laden Mvcs may be a new therapeutic target in the treatment of Eca. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]