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High‐strength foamed ceramics were synthesized employing silicon‐manganese slag (SM) and fluorgypsum (FG) as raw materials, with SiC serving as the foaming agent. Investigations into the influence of firing temperature and FG content on the phase structure, microstructure, and physical properties of foam ceramics were conducted. Characterization of the samples was performed through X‐ray diffraction and scanning electron microscopy. Results indicate that an increase in FG content lowers the matrix melting point, promotes crystal growth, enhances compressive strength, and forms a uniform pore structure. At an FG content of 11%, ceramics prepared at a firing temperature of 1130°C exhibit a density of 0.56 g/cm3, porosity of 78.45%, and compressive strength of 3.05 MPa. This study explores the use of FG as a cost‐effective alternative to borax, demonstrating a sustainable approach for foam ceramics preparation using silicomanganese slag and FG synergy. [ABSTRACT FROM AUTHOR]

Highlights Regulating the dielectric properties of base stations is crucial for advancing 5G technology. This study presents the preparation of a series of graphene/polypropylene (PP) composites by blending various types and concentrations of graphene with PP using a melt blending process. The effect of different graphene types (graphene oxide, multilayer graphene, and exfoliated graphene) and concentrations (0.1, 0.5, 1, and 2 wt%) on the composites was characterized using scanning electron microscope (SEM), X‐ray diffraction (XRD), differential scanning calorimeter (DSC), impedance analyzer, rotational rheometer, and thermal gravimetric analyzer (TGA). Results show that high shear force and temperature during preparation ensure the mechanical and thermal properties of the composites. Specifically, the permittivity decreased by up to 18% with the incorporation of 1% multilayer graphene (MGE). The optimal performance was achieved with MGE compared to graphene oxide (GO) and exfoliated graphene (GE), as the composites exhibited enhanced mechanical strength, thermal stability, and lower permittivitys. This work suggests significant application prospects for PP composite materials in the 5G field due to the excellent characteristics of graphene. Graphene significantly reduces the permittivity of polypropylene. Strong interfacial bonding exists between moderate amounts of graphene and PP. Graphene boosts substrate crystallization to reduce permittivity. Composite permittivity rises with filler's permittivity increase. [ABSTRACT FROM AUTHOR]

In July 2021, the Taklamakan Desert (TD) experienced an unprecedented rainstorm with daily precipitation exceeding 61.1 mm, triggering mudslides and landslides, highlighting the increasing frequency of extreme precipitation events even in arid regions under global warming. The water vapor sources and transport paths of this rainstorm are still puzzling due to the insufficient representation of physical processes in previous analytical models, leading to possible deviations from reality. Here, using the online Eulerian Weather Research and Forecasting model with water vapor tracer (WRF‐WVT), we aim for an improved understanding of water vapor sources of the rainfall event. Results demonstrate that the most important water source for this event is water vapor from local evapotranspiration, contributing to 32.77% of the rainstorm moisture. Water vapor from Upstream Westerlies (28.95%) and East Asian Drylands (28.54%) are transported over the precipitation area by the westerlies owing to the strong lower‐level low‐pressure system, being the second‐most important precipitation source. These sources contribute significantly more than other regions, including the Arabian Sea (5.56%), the Tibetan Plateau (2.16%), and the South Asian Monsoon (0.77%). External moisture sources collectively provide over 65.98% of the precipitation, underscoring their important role. Notably, local evapotranspiration significantly influences precipitation, exceeding the contributions from other individual sources. By comparing with the 2016 precipitation event, it is found that a low‐pressure trough extending southward to the west of the TD plays a significant role in the 2021 rainstorm event. The presence of the trough significantly enhances the moisture transport of the westerlies and the upward motion, contributing to the occurrence of extreme precipitation events. Plain Language Summary: The Taklamakan Desert (TD), widely recognized as one of the driest places on Earth, preserves records of environmental changes. However, despite the dryness and its arid conditions, rainfall is observed under the background of global warming without being completely understood so far. This study focuses on understanding the mechanisms behind rainfall in the TD. We aim to investigate a specific rainstorm event in July 2021, discovering the water vapor sources and transport pathways that transport moisture for hundreds and thousands of kilometers to the desert. Over 65.98% of the precipitation contributing water vapor inflow from outside the desert region. The water vapor originating from the evapotranspiration within the desert accounts for 32.77% of the total precipitation. By describing how and why extreme precipitation has occurred in the TD, this study facilitates understanding the mechanism of extreme precipitation in the region as well as being extrapolated to many other cases. Key Points: The source of water vapor of a rainstorm event in Taklamakan Desert is investigated using WRF‐WVTThe moisture of this rainstorm event primarily comes from external regions, being transported by the westerliesLocal evaporation contributes ∼1/3 water vapor to July 2021 extreme rainfall, whereas external moisture input contributes ∼2/3 [ABSTRACT FROM AUTHOR]

We report a catalytic late‐stage bromination strategy for the α‐C−H functionalization of aryl acetic acid. The aryl acetic acid was transformed into enediolate in the presence of an (AcO)4B2O with the combination of DBU, and consequently underwent an electrophilic bromination reaction with pyridinium tribromide. A wide range of α‐bromo aryl acetic acids were isolated in yields of 19–65 %. In addition, the reaction could be performed on a gram scale, and several transformations of the products were carried out. [ABSTRACT FROM AUTHOR]

Fabric‐reinforced shape memory polymeric composites (SMPC) have shown great potential in the design of intelligent deformation structures. In this work, the weft‐knitted fabric inserted with weft yarns was developed as reinforcement to fabricate the shape memory epoxy polymer (SMEP) composites. The effects of weft yarn, loop density and direction on the shape memory performance of SMPC under different bending radii were experimentally investigated. The results show that the SMPC have good shape fixity ratios and shape recovery ratios of around 98%. As compared with those of SMPCs without inserting weft yarns, the SMPCs with weft yarns have shorter shape recovery time, and the recovery force of SMPCs with weft yarns in the 0° and 90° directions shows an increase of 86.4% and 79.5%, respectively. The recovery force of SMPC improve 3.7 times compared to SMEP. The multiscale models of SMPC were established with basis of the results of micro‐computed tomography scanning of specimens and viscoelastic theory. The surface buckling behaviors of SMEP and SMPC specimens after U‐bending load were discussed. Finally, the deformation of loops and weft yarns of SMPC were analyzed to reveal the shape memory mechanism. Highlights: Shape memory polymeric composites (SMPC) with weft yarns has shorter shape recovery time.Recovery force of SMPC with weft yarns was obvious enhanced.Multi‐scale viscoelastic models of SMPC were established.Surface buckling behaviors of SMPC after U‐bending load were revealed. [ABSTRACT FROM AUTHOR]

SUMMARY: Cotton stands as a pillar in the textile industry due to its superior natural fibers. Lignin, a complex polymer synthesized from phenylalanine and deposited in mature cotton fibers, is believed to be essential for fiber quality, although the precise effects remain largely unclear. In this study, we characterized two ubiquitously expressed cinnamyl alcohol dehydrogenases (CAD), GhCAD37A and GhCAD37D (GhCAD37A/D), in Gossypium hirsutum. GhCAD37A/D possess CAD enzymatic activities, to catalyze the generation of monolignol products during lignin biosynthesis. Analysis of transgenic cotton knockout and overexpressing plants revealed that GhCAD37A/D are important regulators of fiber quality, positively impacting breaking strength but negatively affecting fiber length and elongation percentage by modulating lignin biosynthesis in fiber cells. Moreover, GhCAD37A/D are shown to modulate anther vitality and affect stem lodging trait in cotton by influencing lignin biosynthesis in the vascular bundles of anther and stem, respectively. Additionally, our study revealed that Ghcad37A/D knockout plants displayed red stem xylem, likely due to the overaccumulation of aldehyde intermediates in the phenylpropanoid metabolism pathway, as indicated by metabolomics analysis. Thus, our work illustrates that GhCAD37A/D are two important enzymes of lignin biosynthesis in different cotton organs, influencing fiber quality, anther vitality, and stem lodging. Significance Statement: Our work illustrates that GhCAD37A/D are two important enzymes of lignin biosynthesis in different cotton organs, influencing fiber quality, anther vitality, and stem lodging. [ABSTRACT FROM AUTHOR]

The development of the carbon market is a strategic approach to promoting carbon emission restrictions and the growth of renewable energy. As the development of new hybrid power generation systems (HPGS) integrating wind, solar, and energy storage progresses, a significant challenge arises: how to incorporate the electricity‐carbon market mechanism into the planning of power system capacity. To address this challenge, this article proposes a coupled electricity‐carbon market and wind‐solar‐storage complementary hybrid power generation system model, aiming to maximize energy complementarity benefits and economic efficiency. The model employs a bi‐level optimization method based on the Improved Coati Optimization Algorithm (ICOA) to optimize the system's capacity planning. Simulations reveal that under the coupled electricity‐carbon market scenario, renewable energy capacity increases by 23% over a 5‐year planning period. Additionally, in this scenario, the total cost is 0.042% lower compared to the scenario without coupling. Under the constraint of a 30% renewable energy penetration rate, the capacity development of wind, solar, and storage surpasses thermal power, while demonstrating favourable total cost performance and the comprehensive complementarity index for HPGS. This model offers decision‐making support for optimizing energy resource allocation and improving system reliability and economic viability. [ABSTRACT FROM AUTHOR]

The shape and size‐controlled synthesis of colloidal I−III−VI quantum dots (QDs) can be attained only by a few synthesis strategies via the introduction of various high‐boiling‐point organic surfactants. To further investigate this strategy, in this study, we present a surfactant‐associated controlled synthesis of copper (Cu)‐deficient, zinc (Zn)‐doped Cu─indium (In)─selenium (Se) QDs, followed by a mechanistic investigation of their photophysical properties using surfactants, such as oleylamine (OLA), oleic acid (OA), and diphenylphosphine (DPP). OLA significantly promoted the quantum size effect‐resultant emission wavelength red‐shift, while OA controlled the homogeneous growth of QDs and improved the quantum yields. Moreover, Gaussian deconvolution of the photoluminescence spectra and the bandgap derived from the absorption spectra, by fitting, supported the fact that the radiative transition channels, especially for surface‐trap‐state‐related transitions, are also dependent on the surfactants. Specifically, the conduction band electron‐intragap state transitions and donor‐acceptor transitions were present in all the prepared samples but accounted for different percentages. Furthermore, the surface‐trap‐state‐related transitions significantly faded upon adding (i) OLA/OA as the sole surfactant to the cationic precursor and (ii) the OA + OLA + DPP mixture to the anionic precursor. The findings described here are expected to provide a general strategy for enhancing the tunability of photophysical properties in other QDs systems. [ABSTRACT FROM AUTHOR]

Water structures take an important role in chemical and biological systems, because the structure and function of a molecule may depend on the structure of water with which the molecule interacts. Near‐infrared (NIR) spectroscopy has been proven to be powerful in analyzing the structure of water due to its sensitive response to OH. However, chemometrics is vitally important in the analysis of NIR spectrum of water due to the low resolution of the spectrum and the complexity of the water structures. In this review, chemometric methods for structural analysis of water in aqueous systems, particularly in chemical and biological processes, by NIR spectroscopy were summarized, from the improvement of spectral resolution to the effective extraction of the spectral information of different water structures. Through the changes of the spectral features of the water structures, the structural transformation of proteins, thermo‐responsive polymers, antifreeze agents, as well as the structural variation of water in the transformation were elucidated. Water was proved to be a good probe for analyzing the structure and interactions in aqueous solutions and chemical/biological processes by NIR spectroscopy. [ABSTRACT FROM AUTHOR]

Purpose: To develop a deep learning–based approach to reduce the scan time of multipool CEST MRI for Parkinson's disease (PD) while maintaining sufficient prediction accuracy. Method: A deep learning approach based on a modified one‐dimensional U‐Net, termed Z‐spectral compressed sensing (CS), was proposed to recover dense Z‐spectra from sparse ones. The neural network was trained using simulated Z‐spectra generated by the Bloch equation with various parameter settings. Its feasibility and effectiveness were validated through numerical simulations and in vivo rat brain experiments, compared with commonly used linear, pchip, and Lorentzian interpolation methods. The proposed method was applied to detect metabolism‐related changes in the 6‐hydroxydopamine PD model with multipool CEST MRI, including APT, CEST@2 ppm, nuclear Overhauser enhancement, direct saturation, and magnetization transfer, and the prediction performance was evaluated by area under the curve. Results: The numerical simulations and in vivo rat‐brain experiments demonstrated that the proposed method could yield superior fidelity in retrieving dense Z‐spectra compared with existing methods. Significant differences were observed in APT, CEST@2 ppm, nuclear Overhauser enhancement, and direct saturation between the striatum regions of wild‐type and PD models, whereas magnetization transfer exhibited no significant difference. Receiver operating characteristic analysis demonstrated that multipool CEST achieved better predictive performance compared with individual pools. Combined with Z‐spectral CS, the scan time of multipool CEST MRI can be reduced to 33% without distinctly compromising prediction accuracy. Conclusion: The integration of Z‐spectral CS with multipool CEST MRI can enhance the prediction accuracy of PD and maintain the scan time within a reasonable range. [ABSTRACT FROM AUTHOR]

Egg white (EW)‐derived hydrogels hold promise as biomaterials for in vitro cell culture due to their ability to mimic the extracellular matrix. However, their highly cross‐linked structures restrict their potential for in vivo applications, as they are unable to integrate dynamically with tissues before degradation. In this study, this limitation is addressed by introducing carbon dots (CDs) as cross‐linking agents for EW in a dilute aqueous solution. The resulting CDs‐crosslinked EW hydrogel (CEWH) exhibits tensile strength comparable to that of skin tissue and features a large pore structure that promotes cell infiltration. Subcutaneous implantation of CEWH demonstrated excellent integration with surrounding tissue and a degradation rate aligned with the hair follicles (HFs) regeneration cycle. This allows the long‐term regeneration and establishment of an M2 macrophage‐dominated immune microenvironment, which in turn promotes the re‐entry of HFs into the anagen phase from the telogen phase. Additionally, CEWH demonstrated potential as a wound dressing material. Overall, this study paves the way for utilizing EW as a versatile biomaterial for tissue engineering. [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to identify the risk factors for lung parenchyma hemorrhage and hemoptysis during computed tomography‐guided microwave ablation (MWA) in patients with stage I non‐small cell lung cancer (NSCLC). Methods: A total of 417 patients from two medical centers were included, of whom 353 were from center 1 and 64 were from center 2. The risk factors for lung parenchyma hemorrhage and hemoptysis were selected by univariable and multivariable logistic analyses in the center 1 dataset. The selected risk factors were validated in the center 2 dataset. Results: The risk factors for lung parenchyma hemorrhage during MWA were focal blood supplies (odds ratio [OR], 2.602; 95% confidence interval [CI], 1.609–4.210; p < 0.001), near vessels larger than 2 mm (OR, 4.145; 95% CI, 1.963–8.755; p < 0.001), and traversing vessels in the track of ablation (OR, 2.961; 95% CI, 1.492–5.874; p = 0.002). The risk factors for hemoptysis were lung parenchyma hemorrhage (OR, 34.165; 95% CI, 12.255–95.247; p < 0.001), needle track traversing the lung parenchyma by >25 mm (OR, 4.494; 95% CI, 1.833–11.018; p = 0.001), and traversing vessels in the track of ablation (OR, 5.402; 95% CI, 2.269–12.865; p < 0.001). Conclusions: Focal blood supplies, near vessels larger than 2 mm, and traversing vessels in the track of ablation were independent risk factors for lung parenchyma hemorrhage during MWA. Lung parenchyma hemorrhage, needle track traversing the lung parenchyma by >25 mm, and traversing vessels in the track of ablation were independent risk factors for hemoptysis during MWA. [ABSTRACT FROM AUTHOR]

Materials featuring well‐defined nanoscale channels offer inherent advantages in the selective transport of gases, liquids, and ions, making them pivotal in applications such as molecular separation, catalysis and energy storage. A crucial challenge lies in assembling ordered nanochannel structures and translating these microscopic architectures into macroscopic regular distributions to enhance performance. Nanocomposites provide a promising solution by incorporating nanoscale material (e.g., filler) that significantly enhances macroscale properties of matrix (e.g., polymer). In this review, we spotlight nanocomposite membranes nanocomposite membranes that utilize confinement effects between filler and matrix to precisely control nanochannel apertures, surface properties, and channel distribution for efficient separation of target systems. We discussed the underlying design principles, channel architectures, and strategies for optimizing polymer‐filler interfaces and nanochannel manipulation within functional membranes. Emphasis is placed on the fundamental mechanisms of mass transport, and the structure‐property‐performance relationships within the nanocomposite membranes towards molecular separation. This work aims to provide a comprehensive understanding of how these nanocomposite membranes can be further developed to meet the demands of industrial and environmental applications. [ABSTRACT FROM AUTHOR]

Fault diagnosis plays a vital role in ensuring the operation safety of blast furnaces and improving the quality of molten iron in the ironmaking and steelmaking industry. The blast furnace ironmaking process (BFIP) is intrinsically nonlinear. To address the nonlinearity issue of BFIP, a novel fault diagnosis approach that combines the randomized method, local structure information, and Fisher discriminant analysis is proposed in this paper. Using a randomized feature map, the process data is first mapped onto a randomized explicit low‐dimensional feature space. Compared to kernel methods, explicit low‐dimensional random Fourier features considerably reduce the computational cost, particularly for real‐time fault diagnosis for a large training dataset or a large‐scale process. Additionally, the local structure information contained in the randomized low‐dimensional feature space is extracted. The fault diagnosis performance is improved through the exploration of the local structure of random Fourier features. Finally, the blast furnace iron‐marking process state is determined using Bayesian inference. Case studies on a real‐world BFIP are carried out to demonstrate the superior performance of the proposed method in comparison with other related methods. [ABSTRACT FROM AUTHOR]

On‐farm trials were performed to investigate the nitrogen (N) uptake, N translocation, and grain yield of rice planted via different direct seeding methods into a field after wheat straw incorporation. The study conducted using two direct seeding methods, dry direct seeding of rice (DDSR) and wet direct seeding of rice (WDSR), in a field without or with straw incorporation demonstrated that straw incorporation negatively influenced both grain yield and N uptake in direct‐seeded rice. Compared with WDSR, DDSR suffered significant negative effects, with a 7.2% decrease in grain yield and an 8.0% decrease in N uptake. Additionally, N uptake in direct‐seeded rice with straw addition decreased by 6.5% at the middle stage and 9.5% at the late stage compared with that without straw incorporation. Straw incorporation prolonged the initial phase of growth and thus shortened the N uptake days in the last two phases. Moreover, the total N uptake of rice was positively associated with the uptake rate and the uptake days during the latter stages. Specifically, WDSR exhibited a higher N uptake rate, N uptake days, and N translocation ability than DDSR, which increased the N uptake in stem and panicle, total N uptake, and grain yield at maturity. These results indicated that straw incorporation decreased grain yield and N uptake, which was related to the fewer N uptake days in the latter stages caused by the prolonged early growth stage for direct‐seeded rice. Nevertheless, using WSDR in a field incorporated with straw alleviated the losses in N uptake and grain yield. [ABSTRACT FROM AUTHOR]

In recent years, the research and development of various flexible wearable devices have rapidly advanced due to the continuous introduction of flexible electronic product. These devices have found applications in health monitoring, cardiovascularcare, internal and external workload, and more.Flexible sensors, being a vital component of flexible devices, determine the functionalities and performance capabilities of the devices. Metal nanomaterials, especially silver nanowires, are widely used in flexible sensors in past research due to their great advantages in flexibility and sensitivity. In this work, Silver nanowires with aspect ratios of 600, 1000, and 1400 were synthesized by adjusting the synergy of Br‐ and Cl‐, along with other process parameters, leading to an improved production efficiency of silver nanowires.The stability of the conductive network is enhanced when the aspect ratio of silver nanowires is 1000 and 1400.The sensor demonstrated high sensitivity at high strain, along with an extended strain range.Moreover, it was observed that increasing the aspect ratio of silver nanowires led to a more stable conductive network, thus enhancing the sensor's stability with over 10000 stretching cycles. under the appropriate deposition density, silver nanowires with aspect ratio of 600 have high sensitivity to low strain, and silver nanowires with aspect ratio of 1400 have high sensitivity to high strain, up to 247.3. Introducing microstructures on the surface of PDMS resulted in an increased maximum sensitivity of the sensor with decreasing microstructure size, reaching a maximum sensitivity of 322.2. [ABSTRACT FROM AUTHOR]

Anchorene, identified as an endogenous bioactive carotenoid‐derived dialdehyde and diapocarotenoid, affects root development by modulating auxin homeostasis. However, the precise interaction between anchorene and auxin, as well as the mechanisms by which anchorene modulates auxin levels, remain largely elusive. In this study, we conducted a comparative analysis of anchorene's bioactivities alongside auxin and observed that anchorene induces multifaceted auxin‐like effects. Through genetic and pharmacological examinations, we revealed that anchorene's auxin‐like activities depend on the indole‐3‐pyruvate‐dependent auxin biosynthesis pathway, as well as the auxin inactivation pathway mediated by Group II Gretchen Hagen 3 (GH3) proteins that mainly facilitate the conjugation of indole‐3‐acetic acid (IAA) to amino acids, leading to the formation of inactivated storage forms. Our measurements indicated that anchorene treatment elevates IAA levels while reducing the quantities of inactivated IAA–amino acid conjugates and oxIAA. RNA sequencing further revealed that anchorene triggers the expression of numerous auxin‐responsive genes in a manner reliant on Group II GH3s. Additionally, our in vitro enzymatic assays and biolayer interferometry (BLI) assay demonstrated anchorene's robust suppression of GH3.17‐mediated IAA conjugation with glutamate. Collectively, our findings highlight the significant role of carotenoid‐derived metabolite anchorene in modulating auxin homeostasis, primarily through the repression of GH3‐mediated IAA conjugation and inactivation pathways, offering novel insights into the regulatory mechanisms of plant bioactive apocarotenoids. [ABSTRACT FROM AUTHOR]

This research presents an innovative selected maintenance model for complex systems that considers the uncertainty in maintenance time (MT) for system components with multiple repairpersons. The computational model of uncertain MT for system components is established. An imperfect maintenance model is introduced, which has many imperfect maintenance levels not only considering do nothing, minimal repair, and replacement but also considering multiple intermediate maintenance levels. Furthermore, the system components maintenance assignment algorithm with multiple repairpersons is proposed to addresses the problem of how to assign multiple maintenance tasks to multiple repairpersons in order to minimize system MT. And it is innovatively integrated into the particle swarm optimization (PSO) to solve the proposed selective maintenance model, which enables heuristic algorithm to efficiently assign the multiple maintenance tasks with multiple repairpersons. The effectiveness and advantages of the proposed model and algorithm are verified by numerical experiments. [ABSTRACT FROM AUTHOR]

Aging is usually accompanied by excessive body fat gain, leading to increased susceptibility to comorbidities. This study aimed to explore an unexpected function for the eukaryotic initiation factor‐2α (eIF2α) during aging. Reducing the eIF2α dose led to a reconfiguration of the metabolic equilibrium, promoting catabolism, facilitating lipolysis, and decreasing body fat accumulation while maintaining healthy glucose and lipid metabolism during aging. Specifically, eIF2α enhanced the expression of distinct messenger RNAs encoding mitochondrial electron transport chain proteins at the translation level. The mitochondrial respiration increased in eIF2α heterozygotes, even during aging. Deceleration of translation was demonstrated as a conserved mechanism for promoting longevity across various species. Our findings demonstrated that the restriction of translation by reducing eIF2α expression could fend off multiple tissue damage and improve metabolic homeostasis during aging. Hence, eIF2α was a crucial target for benefiting mammalian aging achieving delayed mammalian aging. [ABSTRACT FROM AUTHOR]

To meet selective adsorption toward trifluralin, a novel molecularly imprinted polymer (MIP) was fabricated by the dummy template molecular imprinting technology. First, computational simulation was performed to select a suitable dummy template, 3,5‐dinitro‐4‐methylbenzoic acid (T1), based on the maximum basis set superposition error (BSSE)‐corrected binding interaction energy (ΔE) of the monomer N‐vinylpyrrolidone (NVP)‐T1 complex and its structural overlap with trifluralin. Then, the MIP was prepared via the bulk polymerization. The adsorption experiments showed the MIP exhibited a trifluralin adsorption capacity of 5.1 mg g−1, an imprinting factor (IF) of 2.2, and short adsorption equilibrium time of 5 min. The adsorption of trifluralin conformed to the Freundlich adsorption (R2 = 0.985) and pseudo‐second‐order model (R2 = 0.999). In addition, the MIP exhibited selectivity to trifluralin over other adsorbents, including structural analogs (pendimethalin and oryzalin), pesticide (carbendazim), and nitrocompounds (nitrofurantoin, furazolidone, and furaltadone), with the selectivity factor (β) in the range of 1.2–3.0, respectively. In trifluralin/oryzalin mixture, the IF toward oryzalin was still as high as 1.9. The removal rate of the MIP to trifluralin in environmental water samples ranged from 90.08% to 99.04%. This study provides theoretical and experimental insights for the preparation of MIP using dummy templates. [ABSTRACT FROM AUTHOR]

The surface‐wrinkled shrinkage structure of spheres is very common and also quite intriguing to explore and reveal the analogous droplet solidification kinetics in the space environment. Here, a liquid‐to‐solid phase transition experiment of floating refractory alloy droplets is designed to study the surface wrinkled shrinkage structures aboard China Space Station with a 10−5 gravity level. The experimental Ti‐Ni‐V alloy droplets undergo an extremely high overheating temperature beyond 1800 K and then achieve a supercooling of 307 K, displaying a strong thermodynamic metastability. The spherical surface deformation structures of this alloy under microgravity coupled with extreme metastable solidification are explored. Moreover, through the active control of metastable rapid solidification, a surface monophasic structure and a B2 structure capable of stress‐induced martensitic transformation are facilitated by wrinkled shrinkage dynamics under microgravity. Their findings shed further light on the surface deformation structures during the microgravity solidification process. [ABSTRACT FROM AUTHOR]

Sodium‐oxygen batteries have been regarded as promising energy storage devices due to their low overpotential and high energy density. Its applications, however, still face formidable challenges due to the lack of understanding about the influence of electrocatalysts on the discharge products. Here, a phosphorous and nitrogen dual‐doped carbon (PNDC) based cathode is synthesized to increase the electrocatalytic activity and to stabilize the NaO2 superoxide nanoparticle discharge products, leading to enhanced cycling stability when compared to the nitrogen‐doped carbon (NDC). The PNDC air cathode exhibits a low overpotential (0.36 V) and long cycling stability (120 cycles). The reversible formation/decomposition and stabilization of the NaO2 discharge products are clearly proven by in‐situ synchrotron X‐ray diffraction and ex‐situ X‐ray diffraction. Based on the density functional theory calculation, the PNDC has much stronger adsorption (−2.85 eV) for NaO2 than that of NDC (−1.80 eV), which could efficiently stabilize the NaO2 discharge products. [ABSTRACT FROM AUTHOR]

The evolution of flexible Zn‐ion batteries (FZIBs) significantly hinges on the development of gel electrolytes, characterized by their mechanical properties, ionic conductivity, and environmentally friendly production processes. The prevailing challenge in this domain has been devising a gel electrolyte that encapsulates all these critical attributes effectively for practical application. This study presents a novel zinc ion gel (Zn‐gel) electrolyte developed for FZIBs, synthesized via ethanol vapor‐induced assembly of cellulose molecules. This innovative process fosters significant hydrogen bonding and ion‐complexation with Zn2+ ions, resulting in a gel with exceptional mechanical strength (0.88 MPa), high ion transference (over 0.7), and impressive ionic conductivity (8.39 mS cm−1). The Zn‐gel enables a FZIB to achieve a reversible capacity of 207.3 mAh g−1 and over 93% Coulombic efficiency after 500 cycles, devoid of liquid electrolyte. Highlighting a promising route for high‐performance, eco‐friendly gel electrolytes, this research advances flexible electronics and portable device applications, demonstrating the profound potential of bio‐based polymers in enhancing energy storage technology. [ABSTRACT FROM AUTHOR]

Paleogeography is the merger of sediment and volcanic facies, depositional settings, tectonic plate movements, topography, climate patterns and ecosystems through time. The construction of paleogeographic maps on tectonic plate reconstruction models requires a team effort to compile databases, data sharing standards and map projection methods. Two goals of the Paleogeography Working Group of the International Union of Geological Sciences (IUGS) program for Deep‐Time Digital Earth (DDE) are: (1) to interlink online national lexicons for all sedimentary and volcanic formations, and develop online ones for nations that currently lack these; (2) to target specific regions and intervals for testing/showcasing paleogeography output from the merger of these databases. Following those goals, we developed and applied new cloud‐based lexicon data services and interactive visualization techniques to regions in East Asia. This has been a successful collaboration among computer engineers and plate modellers and has involved stratigraphers in India (ONGC), China (Chengdu Univ. Tech., and Chinese Acad. Geol. Sci.), United States (Paleomap Project, and Purdue Univ.), Australia (GPlates visualization team) and Vietnam (Vietnam Nat. Univ.). Independent online lexicons with map‐based and stratigraphy‐based user interfaces have been developed (as of the date of this submission in March 2022) for all Proterozoic to Quaternary formations on the Indian Plate (over 800) and Vietnam (over 200), the majority of the Devonian through Neogene of China (ca. 2000) and partially for Thailand. A multi‐database search system returns all geologic formations of a desired geologic time from these four independent databases. With one click, users can plot the regional extent of one or of all of those regional formations on different plate reconstruction models of that desired age, and these polygons are filled with the lithologic facies pattern. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to evaluate the yield and applicability of expanded carrier screening and propose carrier rate screening thresholds suitable for the Chinese population by comparing the current screening panel with the American College of Medical Genetics and Genomics recommended panel of 113 genes. Methods: Using targeted next‐generation sequencing, a customized panel with 334 genes was performed on 2168 individuals without clinical phenotypes for expanded carrier screening purpose. Variant interpretation followed the American College of Medical Genetics and Genomics guidelines. Carrier rates were calculated for each identified variant and each gene. At‐risk couple rates were also assessed. The yield of expanded carrier screening was evaluated through calculating cumulative carrier rate. Results: Overall, 65.87% of the individuals were found to be carriers of at least 1 disease causing variants. The overall at‐risk couple rate was 11.76%, of which the GJB2:c.109G > A related at‐risk couple rate was 5.78%. The cumulative carrier rate of 334‐panel was 65.53%. When screened genes with gene carrier rate ≥1/1000, the expanded carrier screening can cover over 90% of the cumulative carrier rate and at‐risk couples. A total of 86 genes overlapped with American College of Medical Genetics and Genomics Tier‐3 genes and were attributed to the cumulative carrier rate of 47.33%. Conclusion: Expanded carrier screening using the 334‐gene panel showed high screening efficiency. A threshold of gene carrier rate ≥1/1000 is recommended for selecting carrier screening genes in the Chinese Han population. This study highlights the importance of customizing screening panels based on the ACMG Tier‐3 genes in conjunction with population‐specific carrier frequencies to improve the accuracy and effectiveness of expanded carrier screening. Key points: What is already known about this topic?Expanded carrier screening can effectively identify carriers in the general population and reduce the occurrence of genetic disorders. Nevertheless, the inclusion scope of screened diseases and the number of genes for a specific ethnic population has been a topic of ongoing debate. What does this study add?This study conducted carrier screening method development with the data from individuals from the general population and identified genes with high carrier frequencies in the Chinese population.The study highlights the importance of customizing screening panels based on population‐specific carrier frequencies to improve ECS utility. [ABSTRACT FROM AUTHOR]

Background: The clinical impact of obesity on postoperative outcomes of patients undergoing thyroidectomy remains controversial. Methods: Patients aged ≥ 18 years who were diagnosed with thyroid malignancy and underwent thyroidectomy between 2016 and 2020 were included, and divided into two groups: patients with body mass index (BMI) < 30 kg/m2 and those with BMI ≥ 30 kg/m2. Patients in the obese group were then subdivided into four groups: Group 1 (BMI 30.0–34.9 kg/m2), Group 2 (BMI 35.0–39.9 kg/m2), Group 3 (BMI 40.0–44.9 kg/m2), and Group 4 (BMI ≥ 45.0 kg/m2) to evaluate the association between degree of obesity and clinical outcomes. We performed propensity score matching, compared outcome variables between the groups, and conducted adjusted multivariate logistic regression analyses of postoperative outcomes. Results: A total of 6778 patients diagnosed with thyroid cancer who underwent thyroidectomy were screened, of whom 1299 (19.2%) patients were obese. Patients in the obese group had higher total hospital charges (p < 0.001) and an increased risk of overall postoperative complications (34.7% vs. 30.5%, p = 0.023). Specifically, patients in the obese group had increased odds of respiratory complication (adjusted odds ratio (aOR) 1.66, 95% confidence interval (CI) [1.26–2.19]), acute renal failure (aOR 1.87, 95% CI [1.13–3.09]), and wound complication (aOR 2.77, 95% CI [1.21–6.37]) than those in the non‐obese group. Moreover, trend tests showed that the risks of unfavorable discharge, infection, acute renal failure, and respiratory complication all exhibited an upward trend with increased BMI. Conclusion: Obesity is associated with an increased risk of postoperative complications in patients with thyroid cancer undergoing thyroidectomy. This finding suggests that obese patients should be treated with more caution during postoperative recovery. [ABSTRACT FROM AUTHOR]

In this study, a sulfur–phosphorus co‐doped nanocarbon (SPC) catalyst was synthesized using a straightforward one‐step colloidal carbonization method and demonstrated high performance in the metal‐free direct oxidation of alcohols to aldehydes. This metal‐free SPC catalyst showed exceptional efficiency, achieving a conversion rate of 90% for benzyl alcohol and a selectivity of 94% toward benzaldehyde within only 1 h at 130°C. Moreover, it displays exceptional cycle stability and a high turnover frequency (17.1 × 10−3 mol g−1 h−1). Theoretical analysis suggested that the catalyst's superior performance is attributed to the presence of unsaturated edge defects and S−P− moieties, which increase the density of states at the Fermi level, lower the band gap energy, and promote electron localization. Additionally, the doping introduces cooperative co‐active S−P−C sites, facilitating a synergistic multisite catalytic effect that lowers the energy barriers. These findings represent a significant advancement in the field of metal‐free direct alcohol oxidation. [ABSTRACT FROM AUTHOR]

Endowing tactile feedback for prosthetic hands is profound for upper‐limb amputees. However, existing prosthetic hands are generally not in possession of the embedded sensory feedback. Herein, a flexible tactile sensor array which can be integrated into an untethered soft prosthetic hand to achieve static and dynamic discrimination tasks is presented. The flexible piezoresistive sensory arrays with 25 sensor units which can be arranged on five fingers of the soft prosthetic hand are fabricated. According to the collected large‐scale tactile dataset (including pressure distribution and pressure magnitude) during different grasping tasks, a learning‐based classification model that can reveal the correspondences between tactile information and object attributes while interacting with touched objects is developed. To transfer tactile information extracted from tactile sensor arrays, a wearable vibrotactile feedback band with a spatial coding feedback strategy is implemented by selectively activating vibrotactile motors located on the skin of the upper arm. In a set of tests performed by an individual with transradial amputation and eight able‐bodied subjects, the soft prosthetic hand integrated with tactile sensor arrays can help the users regain finger tactile sensation, discriminate grasped objects, and achieve real‐time dynamic rolling detection. [ABSTRACT FROM AUTHOR]

TiO2 is a widely used photoelectric conversion semiconductor material. However, due to its native defects, such as the selective absorption of ultraviolet light and high recombination rate of photogenerated carriers, it exhibits poor photoelectrochemical (PEC) water splitting performance. In this study, intrinsic defect titanium vacancy and semiconductor recombination agents ZnIn2S4 were introduced into an anodization‐annealed TiO2 film (TiO2 NT) to enhance the photoanode activity. The activity‐enhanced TiO2 photoanode (ZIS@TiO2 NT‐EA) was characterized by surface analyses and photoelectrochemical measurements. Mott‐Schottky measurement indicated that the introduction of titanium vacancies into the TiO2 NT changed its semiconductor type from n to p, and significantly reduced its apparent activation energy if compared with the TiO2 NT. In addition, after the ZnIn2S4 nanoparticles were loaded on the TiO2 NT‐EA film, the carrier concentration of the ZIS@TiO2 NT‐EA was nearly 12 times higher than the pristine TiO2 NT. Due to the higher carrier separation efficiency resulting from the formation of p‐n heterojunction between TiO2 and ZnIn2S4, the photocurrent density of the ZIS@TiO2 NT‐EA reached 3.89 mA cm−2 at 1.23 V (vs. RHE), nearly 3 times higher than that of the original TiO2 NT. Amazingly, the maximum applied bias photon‐to‐current efficiency (ABPE) value of the ZIS@TiO2 NT‐EA photoanode reached 2.15 % at 0.496 V (vs. RHE), which is very competitive if compared with all the reported TiO2 film electrodes in the PEC water splitting application. The incident photon‐to current efficiency (IPCE) of the ZIS@TiO2 NT‐EA photoanode was approximately 40.9% at 300 nm, which was about 3 times higher than that of the TiO2 NT (13.6%). To understand these impressive improvements in water splitting, further analyses were conducted on the effect of the increased titanium vacancy concentration in the TiO2 lattice and the formation of p‐n junction between the TiO2 and ZnIn2S4 on the PEC behaviour, as well as on the charge transfer resistance and separation efficiency of carriers. [ABSTRACT FROM AUTHOR]

Land surface phenology encompasses variations in the life cycle events of plants induced by seasonal changes in environmental factors, primarily meteorological conditions. This study leverages Google Earth Engine to extract a comprehensive time series of two‐band Enhanced Vegetation Index (EVI 2) from Landsat images. Utilizing relatively sparse data spanning from 2001 to 2020, a Bayesian hierarchical model is applied at a 30 m resolution to capture the continuous temporal evolution of phenology. The fitting results of this study demonstrate excellent performance, with annual correlation coefficients consistently exceeding 0.89. The findings indicate that between 2001 and 2020, the Start of Season in Shanxi advanced by an average of 0.79 days per year, the End of Season was delayed by an average of 0.83 days per year, and the Length of Season (LOS) extended by an average of 0.80 days per year. Spatial disparities in phenological periods in Shanxi are evident, with an average LOS of 192 days on 35–36° N and only 122 days on 40–41° N. Below 1200 m, phenological periods exhibit significant changes influenced by human activities, while between 1200 m and 2600 m, LOS shows a weak trend of shortening. Above 2600 m, there is a noticeable reduction in LOS. With an increasing slope, LOS increases from an average of 175 days to 187 days (>25°). This study, utilizing Shanxi as a case study, explores the spatiotemporal evolution characteristics of vegetation phenology, aiming to support fine land management and enhance agricultural productivity. [ABSTRACT FROM AUTHOR]

This study explores the interaction between cyanidin‐3‐O‐glucoside (C3G), a water‐soluble pigment known for its diverse functional activities, and walnut protein isolate (WPI) as a potential stabilizing agent. Given the inherent instability of C3G, particularly its limited application in the food industry due to sensitivity to thermal and oxidative conditions, this research study aims to enhance its stability. According to the results of the fluorescence quenching experiment, C3G can efficiently quench WPI's intrinsic fluorescence through static quenching. Structural exploration revealed that C3G bound WPI via hydrophobic interaction force, with the number of bound C3G molecules (n) almost equivalent to 1. The ΔG value denoting change in Gibbs free energy for C3G binding with WPI was −8.05 kJ/mol, which indicated that the interaction between C3G and WPI is spontaneous. Moreover, the conformational structures of WPI were altered by C3G binding with a decrease in α‐helix contents and an increase in β‐turn, β‐sheet, and random coil contents. The thermal degradation kinetics indicate that after interacting with WPI, the half‐life of C3G increased by 1.62 times and 1.05 times at 80 and 95°C, respectively. The results of the oxidation stability test showed that the presence of WPI effectively reduced the discoloration and degradation of C3G caused by oxidation, and improved the oxidation stability of C3G. This study's findings will help to clarify the interaction mechanism between C3G and WPI, and broaden C3G's application scope in the food processing field. [ABSTRACT FROM AUTHOR]

Zinc‐based sorbents with ordered mesoporous structure were modified with aluminium and the key factors in the preparation were optimized based on the results of desulphurization tests performed in a fixed‐bed reactor with simulated coal gas. It was shown that the sorbents for hydrogen sulphide removal reached an optimum sulphur capacity of 9.14% when prepared under conditions of 10.0 crystalline pH, 30:1 Si:Al molar ratio, 0.32:1 Zn:Si molar ratio, and 1:3 Zn:TAA molar ratio. The sorbent without aluminium was synthesized synchronously as a comparison sample to investigate the effect of aluminium addition on the desulphurization properties. The surface acidity of the sorbents is enhanced by the addition of aluminium, and the sulphur capacity of the aluminium‐doped sorbent is consequently lower compared to that of aluminium‐free sorbent. Nevertheless, the aluminium‐doped sorbent shows a significant advantage in stability of performance over multiple desulphurization–regeneration cycles and reaches an 81% retention rate of sulphur capacity after five desulphurization, while the aluminium‐free sorbent is only 51% in contrast. The characterization results manifest that aluminium enters the carrier skeleton and increases the wall thickness, which alleviates the collapse of the carrier pore channels and the agglomeration of the active components during the desulphurization process. Stable pore structures and highly dispersed active components facilitate the mass transfer in the reaction process after multiple desulphurization. As a result, the aluminium‐doped sorbent exhibits better performance stability in high temperature coal gas desulphurization. [ABSTRACT FROM AUTHOR]

Idiopathic pulmonary fibrosis is a progressive and age‐related disease that results from impaired lung repair following injury. Targeting senescent myofibroblasts with senolytic drugs attenuates pulmonary fibrosis, revealing a detrimental role of these cells in pulmonary fibrosis. The mechanisms underlying the occurrence and persistence of senescent myofibroblasts in fibrotic lung tissue require further clarification. In this study, we demonstrated that senescent myofibroblasts are resistant to apoptosis by upregulating the proapoptotic protein BAX and antiapoptotic protein BCL‐2 and BCL‐XL, leading to BAX inactivation. We further showed that high levels of inactive BAX‐mediated minority mitochondrial outer membrane permeabilization (minority MOMP) promoted DNA damage and myofibroblasts senescence after insult by a sublethal stimulus. Intervention of minority MOMP via the inhibition of caspase activity by quinolyl‐valyl‐O‐methylaspartyl‐[2,6‐difluorophenoxy]‐methyl ketone (QVD‐OPH) or BAX knockdown significantly reduced DNA damage and ultimately delayed the progression of senescence. Moreover, the BAX activator BTSA1 selectively promoted the apoptosis of senescent myofibroblasts, as BTSA1‐activated BAX converted minority MOMP to complete MOMP while not injuring other cells with low levels of BAX. Furthermore, therapeutic activation of BAX with BTSA1 effectively reduced the number of senescent myofibroblasts in the lung tissue and alleviated both reversible and irreversible pulmonary fibrosis. These findings advance the understanding of apoptosis resistance and cellular senescence mechanisms in senescent myofibroblasts in pulmonary fibrosis and demonstrate a novel senolytic drug for pulmonary fibrosis treatment. [ABSTRACT FROM AUTHOR]

Reactive oxygen species (ROS)‐induced oxidative DNA damages have been considered the main cause of mutations in genes, which are highly related to carcinogenesis and tumour progression. Extracellular vesicles play an important role in cancer metastasis. However, the precise role of DNA oxidative damage in extracellular vesicles (EVs)‐mediated cancer cell migration and invasion remains unclear. Here, we reveal that ROS‐mediated DNA oxidative damage signalling promotes tumour metastasis through increasing EVs release. Mechanistically, 8‐oxoguanine DNA glycosylase (OGG1) recognises and binds to its substrate 8‐oxo‐7,8‐dihydroguanine (8‐oxoG), recruiting NF‐κB to the synaptotagmin 7 (SYT7) promoter and thereby triggering SYT7 transcription. The upregulation of SYT7 expression leads to increased release of E‐cadherin‐loaded EVs, which depletes intracellular E‐cadherin, thereby inducing epithelial‐mesenchymal transition (EMT). Notably, Th5487, the inhibitor of DNA binding activity of OGG1, blocks the recognition and transmission of oxidative signals, alleviates SYT7 expression and suppresses EVs release, thereby preventing tumour progression in vitro and in vivo. Collectively, our study illuminates the significance of 8‐oxoG/OGG1/SYT7 axis‐driven EVs release in oxidative stress‐induced tumour metastasis. These findings provide a deeper understanding of the molecular basis of cancer progression and offer potential avenues for therapeutic intervention. [ABSTRACT FROM AUTHOR]

Background: McLeod syndrome (MLS) and chorea‐acanthocytosis (ChAc) are exceedingly rare diseases characterized by a variety of movement disorders including chorea, dystonia, and Parkinsonism. Genetic analysis plays a key role in early and accurate diagnosis, but relevant variants are still under investigation. This study aims to explore new pathogenic variants in Chinese patients with MLS and ChAc and to conduct a comprehensive analysis of the clinical heterogeneity among these patients. Methods: Eighteen Chinese patients who presented with choreatic movements with negative HTT genetic testing were identified and underwent targeted next‐generation sequencing, verified by Sanger sequencing. Results: Two novel XK variants (c.970A>T, c.422_423del) were identified in three index MLS patients and six novel VPS13A variants (c.9219C>A, c.3467T>A, c.4208dup, c.9243_9246del, c.5364del, c.556‐290_697‐483del) in five index ChAc patients. One copy number variant of VPS13A (g.79827595_79828762del/c.556‐290_697‐483del) was firstly described in Chinese population. Conclusion: As the currently largest descriptive study of MLS and ChAc patients in China, this study expands on the clinical and genetic spectrum of XK and VPS13A, contributing to the clinical diagnosis of MLS and ChAc. [ABSTRACT FROM AUTHOR]

A series of SiC/SiC composites were fabricated through the precursor infiltration and pyrolysis (PIP) process, using solid polycarbosilane (PCS) and liquid vinyl perhydrogen PCS (VHPCS) solutions as impregnating agents. The physicochemical characteristics of the SiC matrices derived from PCS and VHPCS were investigated and compared. The impact of the PCS composition on the microstructure, density, flexural strength, and modulus of the resulting SiC/SiC composites was also examined. As the VHPCS content increased to 60 wt%, the flexural strength of the composites gradually rose to a peak of 490.9 MPa before decreasing as the VHPCS proportion continued to increase. Meanwhile, the flexural modulus increased continually with the introduction of VHPCS. A possible mechanism is proposed to explain the different variations in flexural strength and modulus, taking into account the ceramic toughening principle and the distinct properties of PCS and VHPCS. [ABSTRACT FROM AUTHOR]

In this article, we propose a mobile edge computing (MEC)‐related system named PD‐Gait, which can measure gait parameters of Parkinson's disease patients in a contactless and privacy‐preserving manner. We utilize inaudible acoustic signals and band‐pass filters to achieve privacy data protection in the physical layer. The proposed framework can be easily deployed in the mobile end of MEC, and hence release the edge server in cybersecurity attacks fighting. The gait parameters include stride cycle time length and moving speed, and hence providing an objective basis for the doctors' judgment. PD‐Gait utilizes acoustic signals in bands from 16 to 23 kHz to achieve device‐free sensing, which would release both doctors and patients from the tedious wearing process and psychological burden caused by traditional wearable devices. To achieve robust measurement, we propose a novel acoustic ranging method to avoid "broken tones" and "uneven peak distribution" in the received data. The corresponding ranging accuracy is 0.1 m. We also propose auto‐focus micro‐Doppler features to extract robust stride cycle time length, and can achieve an accuracy of 0.052 s. We deployed PD‐Gait in a brain hospital and collected data from 8 patients. The total walked distance is over 330 m. From the overall trend, our results are highly correlated with the doctor's judgment. [ABSTRACT FROM AUTHOR]

Purpose: Autostereoscopic displays have become increasingly common, but their impact on ocular dimensions remains unknown. We sought to identify changes in the crystalline lens dimensions induced by autostereoscopic three‐dimensional (3D) viewing. Methods: Forty young adults (age: 22.6 ± 2.0 years, male/female: 15/25) were consecutively enrolled and randomly divided into two groups (3D and two‐dimensional [2D] viewing groups) to watch a 30‐min movie clip displayed in 3D or 2D mode on a tablet computer. The lens thickness (LT), diameter, curvature, decentration and tilt were measured with anterior segment optical coherence tomography under both non‐accommodating (static) and accommodating conditions. Results: In the static condition, the LT decreased by 0.03 ± 0.03 mm (p < 0.001) and the anterior radius of curvature (ARC) increased by 0.49 ± 0.59 mm (p = 0.001) post‐3D viewing. In contrast, following 2D viewing, the ARC decreased by 0.23 ± 0.25 mm (p = 0.001). Additionally, the increase in the steep ARC post‐3D viewing was greater in high‐myopic eyes than low to moderate myopic eyes (p = 0.04). When comparing the accommodative with the static (non‐accommodative) condition, for 3D viewing the lens decentration decreased (−0.03 ± 0.05 mm, p = 0.02); while for 2D viewing, the posterior curvature radius (−0.14 ± 0.20 mm, p = 0.006) and diameter (−0.13 ± 0.20 mm, p = 0.01) decreased. Conclusions: Viewing with the autostereoscopic 3D tablet could temporally decrease the thickness and curvature of the lens under non‐accommodating conditions. However, its long‐term effect requires further exploration. [ABSTRACT FROM AUTHOR]

Phillygenin (PHI) is an active ingredient derived from the leaf of Forsythia suspensa that has been found to alleviate inflammation and peroxidation response. Avian infectious bronchitis (IB) is a major threat to poultry industry viral respiratory tract disease that infected with infectious bronchitis virus (IBV). This study investigated the protection of PHI to CEK cell and broiler's tracheal injury triggered by avian infectious bronchitis virus (IBV). The results showed that IBV infection did not cause serious clinical symptoms and slowing‐body weight in PHI‐treated broilers. The expression of virus loads, pro‐inflammation factors (IL‐6, TNF‐α, and IL‐1β) in CEK cell, and tracheas were decreased compared to the IBV group, exhibiting its potent anti‐inflammation. Mechanistically, the study demonstrated that the inhibition of TLR7/MyD88/NF‐κB pathway was mainly involved in the protection effect of PHI to inflammation injury. Interestingly, a higher abundance of Firmicutes and Lactobacillus in respiratory tract was observed in PHI‐treated broilers than in the IBV group. Significant differences were observed between the IBV group and PHI‐treated group in the Ferroptosis, Tryptophan metabolism, and Glutathione metabolism pathways. PHI exhibited potent protection effect on IBV infection and alleviated inflammation injury, mainly through inhibiting TLR7/MyD88/NF‐κB pathway. The study encourages further development of PHI, paving the way to its clinical use as a new candidate drug to relieve IBV‐induced respiratory symptoms. [ABSTRACT FROM AUTHOR]