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The aim of this systematic review was to determine the positive and negative outcomes of working with children who had experienced sexual abuse for health and social care professionals. The following four databases were searched using predetermined terms: PsycINFO, PubMed, CINAHL and Web of Science. Inclusion criteria included peer‐reviewed qualitative, quantitative, multi‐method or mixed method studies written in the English language. Study identification, quality assessment and data extraction were independently completed by two researchers, with a high degree of inter‐rater reliability. Eight studies (six qualitative, one quantitative and one multi‐method) met the inclusion criteria. Reviewed studies were conducted in the United States, Israel, Ireland and South Africa. Both positive and negative outcomes for healthcare professionals working with childhood sexual abuse (CSA) were identified. Additionally, a range of personal and contextual mitigating and risk factors were identified that may affect professionals' vulnerability to negative outcomes from CSA work, which have implications for practice. Due to the limited evidence base, clinical implications are tentative. Future research should adopt longitudinal methodologies and focus on participants from a range of disciplines and work contexts, particularly outside the United States. [ABSTRACT FROM AUTHOR]

Objective: This study investigated associations between childhood trauma, parental bonding, and social cognition (i.e., Theory of Mind and emotion recognition) in patients with schizophrenia and healthy adults. Methods: Using cross‐sectional data, we examined the recollections of childhood trauma experiences and social cognitive abilities in 74 patients with schizophrenia and 116 healthy adults. Results: Patients had significantly higher scores compared with healthy participants on childhood trauma, and lower scores on parental bonding and social cognitive measures. Physical neglect was found to be the strongest predictor of emotion recognition impairments in both groups. Optimal parental bonding attenuated the impact of childhood trauma on emotion recognition. Conclusion: The present study provides evidence of an association between physical neglect and emotion recognition in patients with schizophrenia and healthy individuals and shows that both childhood trauma and parental bonding may influence social cognitive development. Psychosocial interventions should be developed to prevent and mitigate the long‐term effects of childhood adversities. [ABSTRACT FROM AUTHOR]

Background Tinea pedis (athlete's foot) is a fungal infection that is both widespread and challenging to treat. Standard treatments consist of topical and systemic therapies of antifungal agents, such as miconazole, itraconazole, and terbinafine. The extended nature of topical therapy and the toxicity of long-term systemic therapy limit the utility of current treatments. An alternate approach relies on an understanding of bacterial-fungal interactions. Specifically, a probiotic antifungal bacterium such as Janthinobacterium lividum can counter infection; Janthinobacterium is a major constituent of the human skin microbiota. Janthinobacterium lividum has been shown to ameliorate the effects of the cutaneous fungal disease chytridiomycosis in a vertebrate species ( Rana muscosa). Methods Dual-culture plate challenge assays were performed using J. lividum and Trichophyton rubrum, the leading cause of athlete's foot. Results In all cases, T. rubrum colonies grew significantly smaller when co-cultured with J. lividum. Conclusion These in vitro results suggest that J. lividum merits further investigation as a human cutaneous probiotic. [ABSTRACT FROM AUTHOR]

Background Tinea pedis (athlete’s foot) is a fungal infection that is both widespread and challenging to treat. Standard treatments consist of topical and systemic therapies of antifungal agents, such as miconazole, itraconazole, and terbinafine. The extended nature of topical therapy and the toxicity of long-term systemic therapy limit the utility of current treatments. An alternate approach relies on an understanding of bacterial–fungal interactions. Specifically, a probiotic antifungal bacterium such as Janthinobacterium lividum can counter infection; Janthinobacterium is a major constituent of the human skin microbiota. Janthinobacterium lividum has been shown to ameliorate the effects of the cutaneous fungal disease chytridiomycosis in a vertebrate species (Rana muscosa). Methods Dual-culture plate challenge assays were performed using J. lividum and Trichophyton rubrum, the leading cause of athlete’s foot. Results In all cases, T. rubrum colonies grew significantly smaller when co-cultured with J. lividum. Conclusion These in vitro results suggest that J. lividum merits further investigation as a human cutaneous probiotic. [ABSTRACT FROM AUTHOR]

The objective of the study was to determine whether associations between dysfunctional beliefs and attitudes about sleep and sleep disturbance are evident in children. Cross-sectional data were collected from 123 children aged 8–10 years (49% boys). The participants came from ethnically diverse backgrounds from two inner-city schools in London, UK. Children completed the Sleep Self-Report (SSR) and the Dysfunctional Beliefs and Attitudes about Sleep (DBAS) questionnaire (which was adapted for use with children). Parents completed the Child Sleep Habits Questionnaire (CSHQ). The total DBAS score was associated with sleep disturbances defined as total SSR score ( β = 0.40, P < 0.001, r2 = 0.15), the SSR insomnia items ( β = 0.29, P < 0.01, r2 = 0.08) and the total CSHQ score ( β = 0.22, P < 0.05, r2 = 0.04). Some dysfunctional beliefs about sleep predicted sleep disturbance to a greater extent than others. For example, when controlling for the other DBAS subscales, the ‘control and predictability of sleep’ subscale, but not the ‘sleep requirements expectations’ subscale, predicted total SSR score and SSR insomnia items. Given this preliminary evidence that dysfunctional beliefs and attitudes about sleep appear to be associated with sleep difficulties in children, future work is needed to further developmentally adapt a version of the DBAS appropriate for use with children. [ABSTRACT FROM AUTHOR]

Variation in cognitive performance, which strongly predicts functional outcome in schizophrenia (SZ), has been associated with multiple immune‐relevant genetic loci. These loci include complement component 4 (C4A), structural variation at which was recently associated with SZ risk and synaptic pruning during neurodevelopment and cognitive function. Here, we test whether this genetic association with cognition and SZ risk is specific to C4A, or extends more broadly to genes related to the complement system. Using a gene‐set with an identified role in "complement" function (excluding C4A), we used MAGMA to test if this gene‐set was enriched for genes associated with human intelligence and SZ risk, using genome‐wide association summary statistics (IQ; N = 269 867, SZ; N = 105 318). We followed up this gene‐set analysis with a complement gene‐set polygenic score (PGS) regression analysis in an independent data set of patients with psychotic disorders and healthy participants with cognitive and genomic data (N = 1000). Enrichment analysis suggested that genes within the complement pathway were significantly enriched for genes associated with IQ, but not SZ. In a gene‐based analysis of 90 genes, SERPING1 was the most enriched gene for the phenotype of IQ. In a PGS regression analysis, we found that a complement pathway PGS associated with IQ genome‐wide association studies statistics also predicted variation in IQ in our independent sample. This association (observed across both patients and controls) remained significant after controlling for the relationship between C4A and cognition. These results suggest a robust association between the complement system and cognitive function, extending beyond structural variation at C4A. [ABSTRACT FROM AUTHOR]