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In patients with haemophilia A, repeated occurrences of haemarthrosis and synovitis lead to limitations in range of motion ( ROM) of major joints. However, the effect of limitations in joint ROM on health-related quality of life ( HRQOL) in these patients has not been studied previously. The aim of this study was to assess the impact of ROM limitations of 10 major joints (bilateral shoulders, elbows, hips, knees and ankles), combined with other possibly influential factors, on HRQOL in patients with haemophilia A. The ROM limitations in 13 movements and pain intensity of the 10 major joints were measured. The socio-demographic and clinical data were recorded. Short-Form 36 was used as the HRQOL measurement. Eighteen patients (mean age: 36.9 years) were included. Hip ROM limitations, knee ROM limitations and hip pain intensity predicted physical functioning scale ( P < 0.001; adjusted R2 = 0.553). Shoulder ROM limitations and age predicted role limitation were due to emotional problems scale ( P < 0.001; adjusted R2 = 0.373). Elbow ROM limitations and haemophilia severity predicted mental health scale ( P = 0.001; adjusted R2 = 0.320). Hip ROM limitations predicted social functioning scale ( P = 0.041; adjusted R2 = 0.091). Educational level and elbow ROM limitations predicted vitality scale ( P < 0.001; adjusted R2 = 0.416). The ROM limitations of hip, knee, shoulder and elbow could be predictors for HRQOL in patients with haemophilia A. Improving ROM of major joints could be an appropriate treatment strategy to enhance HRQOL in these patients. [ABSTRACT FROM AUTHOR]