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Objectives: To examine real‐world characteristics, journey, and outcomes among patients with locoregional, nonmetastatic renal cell carcinoma (RCC). Methods: A retrospective analysis of medical records from the ConcertAI Oncology Dataset was performed on adults in the United States with newly diagnosed nonmetastatic RCC between January 2012–December 2017 who received surgical treatment, and were followed until August 2021. Patients were stratified based on the risk of recurrence after nephrectomy. Recurrence rate and survival outcomes were assessed. Results: The cohort (n = 439) had a median age of 64 years, 66.1% were male, and 76.5% had clear‐cell histology. The median follow‐up time from nephrectomy was 39.3 months overall, 41.0 months for intermediate‐high‐risk patients (n = 377; 85.9%) and 24.1 months for high‐risk patients (n = 62; 14.1%). For intermediate‐high‐ and high‐risk patients, respectively, 68.4% and 56.5% had ≥1 medical oncologist visit after nephrectomy. Of 260 patients with documentation of postoperative imaging assessments, 72% were ordered by medical oncologists, and the median time from initial nephrectomy to the first scan was 110 days (intermediate‐high‐risk) and 51 days (high‐risk). Provider‐documented recurrence occurred in 223 (50.8%) patients, of whom 41.7% had ≥1 medical oncologist visit before the recurrence. Three‐year disease‐free survival (DFS), and overall survival rates were 49.4% and 80.8% (all patients): 27.7% and 64.7% (high‐risk); and 52.9% and 83.3% (intermediate‐high‐risk). Conclusions: Our study reports low DFS after nephrectomy for patients with intermediate‐high‐ and high‐risk RCC. Subsequent approval and use of new and newly approved adjuvant therapeutic options could potentially delay or prevent recurrence. [ABSTRACT FROM AUTHOR]

High‐frequency (HF) radar monitors the sea surface current velocity and provides information for tsunami early warning. SeaSondeR, an HF ocean radar system in the eastern Tsugaru Strait, Japan, measured the tsunami‐induced current velocity during the 2022 Tonga volcanic tsunami. As an air‐coupled tsunami, the generating mechanism was complex, making it difficult to predict coastal tsunamis using traditional early warning methods. We adopted the tsunami data assimilation (DA) approach, which reconstructs the tsunami wavefield using offshore data and does not require source information, to forecast the coastal tsunami waveforms. Observations from the HF radar and offshore bottom pressure gauges (OBPGs) were used as the input for tsunami DA. The assimilation process started at 09:00 (UTC, hereafter) and forecasts were made at 14:00 and 15:00. The surface current velocity recorded by the HF radar reached the maximum (∼0.25 m/s) at 13:00, which corresponded to a negative phase of ∼2 cm sea level variation observed by OBPGs. We compared the forecasted waveforms with the observed waveforms at Hakodate and Shimokita tide gauges. The assimilation results obtained using HF radar showed a better performance in tsunami forecasting than those using OBPG in this case study. At 14:00, the forecasting accuracy indices were 91% and 67% for the next 2 and 6 hr, respectively. At 15:00, it was 63% and 70% for the next 2 and 6 hr, respectively. We suggest that HF radar could be a good supplement to OBPG for tsunami early warning purposes. Plain Language Summary: On 15 January 2022, the eruption of the Hunga Tonga–Hunga Ha'apai volcano generated a tsunami that arrived in Japan. The tsunami was detected by a high‐frequency (HF) ocean radar system in the eastern Tsugaru Strait. The HF radar recorded the velocity of tsunami‐induced sea surface currents. We used these velocity data to forecast the tsunami waveforms at coastal tide gauge stations. The forecast method, called tsunami data assimilation, does not require tsunami source information but accurately forecasts the coastal tsunami waveforms. We demonstrate that the HF radar data can be successfully applied to tsunami early warning systems. Key Points: High‐frequency (HF) radar observed surface current velocity in the eastern Tsugaru Strait during the 2022 Tonga volcanic tsunamiHF radar observations were used for data assimilation to forecast tsunami waveforms at coastal tide gaugesThe assimilation results using HF radar had an accuracy of over 63% for Hakodate and Shimokita tide gauges [ABSTRACT FROM AUTHOR]

Carbon black (CB) particles were employed as a reinforcing filler in carboxyl‐terminated butadiene acrylonitrile rubber (CTBN)/epoxy resin (diglycidyl ether of bisphenol‐A (DGEBA))/aromatic diamine (diamino diphenyl methane (DDM)) network polymer blends. The strength, modulus, and ability to absorb impact energy of the resulting composites were evaluated. The aim of this work was to determine the effects of interfacial interactions between components, and processing conditions (especially temperature) on mechanical properties. The application of high temperatures during the kneading process resulted in strong interfacial interactions between the CB particles and the CTBN. The formation of strong bonds at the CB/CTBN interfaces during kneading was the key factor in obtaining high strength and high impact energy absorbance. The composites also exhibited good adhesive strength during both shear and peel stress tests. [ABSTRACT FROM AUTHOR]

Abstract: Introduction: Diabetes mellitus is a progressive disease with cardiovascular complications. This study evaluated the effects of liraglutide, a glucagon‐like peptide‐1 analogue and the dipeptidyl peptidase 4 inhibitors sitagliptin and linagliptin on cardiac function in type 2 diabetes patients with renal impairment. Materials and Methods: A total of 139 patients who were referred because of suboptimal glycaemic control were randomly assigned to liraglutide 0.9 mg/d (n = 45), sitagliptin 50 mg/d, (n = 49) or linagliptin 5 mg/d (n = 45) at enrolment and were evaluated. Blood glucose, glycosylated haemoglobin and serum creatinine were assayed every 3 months for 48 months. Echocardiography was performed every 12 months for 48 months. Results: Compared with baseline, fasting glucose, postprandial glucose, and systolic and diastolic pressure, but not estimated glomerular filtration rate, significantly decreased in all three groups. Albuminuria decreased from 24 to 48 months with liraglutide, but only from 24 to 30 months with sitagliptin and linagliptin. Diastolic function, assessed by E/e′ or left atrial dimension improved only with liraglutide. Conclusions: Liraglutide was effective for glucose and blood pressure control, reduced albuminuria and improved diastolic function. Diastolic function was not improved by sitagliptin and linagliptin. [ABSTRACT FROM AUTHOR]

Solitary pulmonary capillary hemangioma ( SPCH) is a rare benign lung tumor that must be distinguished from small and early lung cancers. Here, we report a case of SPCH for which we performed frozen section diagnosis. The patient was a 55-year-old Japanese woman. Five years before the operation, mixed ground-glass opacity was detected by computed tomography in the left posterior basal segment of the lower lobe ( S10). Because the interior tumor density of the ground-glass opacity increased slightly, video-assisted thoracic surgery wedge resection was performed. Frozen section diagnosis revealed a benign tumor without proliferation of atypical epithelial cells. The tumor had narrow alveolar lumens, thickened alveolar septa and a clear boundary separating it from normal lung tissue. The proliferated lumens varied in size and were lined with single layers of flat cells. After the operation, immunohistochemical staining of a paraffin section revealed that the thickened alveolar septa resulted from the proliferation of capillary vessels, the flat cells of which were positive for CD31 and CD34 and negative for podoplanin; the tumor was diagnosed as SPCH. Here, we discuss the pathological features of SPCH on frozen sections with reference to this case and review previous related reports. [ABSTRACT FROM AUTHOR]