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An efficient method for the synthesis of α‐fluoroamides having C–F quaternary stereogenic center was achieved by a one‐pot four‐component strategy under mild reaction conditions. A variety of α‐fluoroamides was synthesized by using 1,3‐dicarbonyl, isocyanide, acetylenedicarboxylate and N‐fluorobenzenesulfonimide (NFSI) systems with good to excellent yields up to 93 %. The current protocol proceeds through the unstable 3‐fluoro 4H‐pyran intermediate, which is key for the reaction and further it can be hydrolyzed due to the high electronegativity of the fluorine atom to produce the desired α‐fluoroamides. [ABSTRACT FROM AUTHOR]

We have successfully accomplished gem‐difluorination of triazole alkyl functionalized amino pyrazoles in the presence of Selectfluor under dry condition and obtained 4,4‐difluoro pyrazol‐3‐imines derivatives in high yield. However, in the presence of water, 4,4‐difluoro pyrazol‐3‐one derivatives were afforded. Gem‐difluorination of triazole alkyl functionalized amino pyrazoles was successfully accomplished in the presence of Selectfluor under dry condition and 4,4‐difluoro pyrazol‐3‐imines derivatives were obtained in high yield. [ABSTRACT FROM AUTHOR]

An unprecedented Domino transformation towards diverse fluorinated spiro benzothiazinyl furanone scaffolds has been developed from 1,3-diketone embedded benzothiazines and Selectfluor through fluorinative intramolecular cyclization. The transformation is triggered by fluorine insertion to form a difluoro intermediate, which is responsible for the formation of fluorinated spiro 3(2H)-furanone derivatives. We have also succeeded to synthesize non-fluorinated spiro 3(2H)-furanone derivatives by oxidative cyclization using AgF. [ABSTRACT FROM AUTHOR]