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BACKGROUND AND PURPOSE Hyperphosphataemia is common in patients with nephrogenic systemic fibrosis (NSF). NSF has been linked to administration of gadolinium (Gd) chelates (GCs) and elevated serum phosphate levels accelerate the release of Gd from linear, non-ionic GCs but not macrocyclic GCs. Hence, we determined whether hyperphosphataemia is a cofactor or risk factor for NSF by investigating the role of hyperphosphataemia in renally impaired rats. EXPERIMENTAL APPROACH Firstly, the clinical, pathological and bioanalytical consequences of hyperphosphataemia were investigated in subtotal nephrectomized (SNx) Wistar rats following i.v. administration of the non-ionic, linear GC gadodiamide (5 × 2.5 mmol·kg−1·day−1). Secondly, the effects of several GCs were compared in these high-phosphate diet fed rats. Total Gd concentration in skin, femur and plasma was measured by inductively coupled plasma mass spectrometry (ICP-MS) and free Gd3+ in plasma by liquid chromatography coupled to ICP-MS. Relaxometry was used to measure dissociated Gd in skin and bone. KEY RESULTS Four out of seven SNx rats fed a high-phosphate diet administered gadodiamide developed macroscopic and microscopic (fibrotic and inflammatory) skin lesions, whereas no skin lesions were observed in SNx rats treated with saline, the other GCs and free ligands or in the normal diet, gadodiamide-treated group. Unlike the other molecules, gadodiamide gradually increased the r1 relaxivity value, consistent with its in vivo dissociation and release of soluble Gd. CONCLUSIONS AND IMPLICATIONS Hyperphosphataemia sensitizes renally impaired rats to the profibrotic effects of gadodiamide. Unlike the other GCs investigated, gadodiamide gradually dissociates in vivo. Our data confirm that hyperphosphataemia is a risk factor for NSF. [ABSTRACT FROM AUTHOR]

This Letter reports on new experimental high dynamic range sub‐sampling performances obtained from nanoscale microwave photoconductive switches operating under a 0.8 µm wavelength pulsed illumination. Experimental results have been performed on different samples benefiting of a low temperature grown Gallium Arsenide absorbing layer on GaAs substrate, coplanar microwave electrode profile optimisation, and the use of an ultra‐low noise jitter optical source delivering optical pulses of 1 to10 ps pulse width at a 2 GHz repetition frequency at 0.8 µm optical wavelength. Thanks to carrier lifetime tunability achievement from 1 to 20 ps, in association with a carrier mobility of 3900 cm²/V.s, experimental demonstrations of 54 and 45 dB signal‐to‐noise ratio microwave signal sampling for signals at 5,76 and 20 GHz frequency bandwidth respectively confirms submicron devices functionality as a new class of single channel photonic analogue to digital converters. [ABSTRACT FROM AUTHOR]