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This study considered a dynamic feature of mixed convection flow from a vertical porous plate with the combined effects of nonlinear thermal radiation and exponentially decaying heat generation. The importance of the nonlinear density variation with temperature (NDT), suction/injection, and convecting heating is also analyzed. The reduced ODEs are solved numerically through Runge‐Kutta Ferhlberg fourth‐fifth order in Maple 2022 software. The results obtained show that, by increasing the strength of the mixed convection process, the internal heat generated covects away lesser fluid particles and hence enhances the rate of heat flowing from the porous plate for both suction/injection scenarios. For weak particle suction/injection, the heat flowing from the porous plate into the free stream region increases at a higher internal heat generation parameter. At a higher Prandtl number, lesser fluid is accumulated in the boundary layer, which in turn decreases the plate shear stress. For weak convection and suction/injection effects, the rate at which the heat flowing from the plate into the free stream increases with convective heat transfer propagation. Suction propagation decreases the boundary layer thickness, which consequently enhances the heat transfer rate, whereas the opposite is true for injection. [ABSTRACT FROM AUTHOR]

Background: Imbalance is the most commonly reported side effect following focused ultrasound (FUS) thalamotomy for essential tremor (ET). It remains unknown which patients are more likely to develop imbalance following FUS treatment. Objective: To identify preoperative and treatment‐related sonication parameters that are predictive of imbalance following FUS treatment. Methods: We retrospectively collected demographic data, preoperative Fahn‐Tolosa‐Marin Clinical Rating Scale for Tremor (FTM) scores and FUS treatment parameters in patients undergoing FUS thalamotomy for treatment of ET. The presence of imbalance was evaluated at several discrete time‐points with up to 4 years of follow‐up. Multiple machine learning classifiers were built and evaluated, aiming to maximize accuracy while minimizing feature set. Results: Of the 297 patients identified, the presence of imbalance peaked at 1 week following operation at 79%. This declined rapidly with 29% reporting imbalance at 3 months, and only 15% at 4 years. At 1 week, total preoperative FTM scores and Maximum Energy delivered in FUS could predict the presence of imbalance at 92.8% accuracy. At 3 months, the total preoperative FTM scores and maximum power delivered could predict the presence of imbalance with 90.6% accuracy. Post‐operative lesion size and extent into thalamic nuclei, internal capsule, and subthalamic regions were identified as likely key underlying drivers of these predictors. Conclusions: A machine learning model based on preoperative tremor scores and maximum energy/power delivered predicted the development of short‐term imbalance and long‐term imbalance following FUS thalamotomy. [ABSTRACT FROM AUTHOR]

Leukaemia, a group of haematological malignancies, presents ongoing diagnosis, prognosis, and treatment challenges. A major obstacle in treating this disease is the development of drug resistance. Overcoming drug resistance poses a significant barrier to effective leukaemia treatment. The emergence of exosome research has unveiled new insights into the probable theragnostic implementations in leukaemia. Various research has exhibited the diagnostic possibilities of exosomes in identifying leukaemia‐specific biomarkers, including genetic mutations and fusion transcripts. Additionally, exosomes have been implicated in disease progression and treatment response, rendering them appealing targets for therapeutics. Exosomes, originating from diverse cell types, are instrumental in intercellular communication as they participate in the functional transportation of molecules like proteins, nucleic acids and lipids across space. Exosomes have a dual role in immune regulation, mediating immune suppression and modulating anti‐leukaemia immune responses. Interestingly, exosomes can even act as drug transport vehicles. This review delves into the intricate process of exosome biogenesis, shedding light on their formation and release from donor cells. The key mechanisms engaged in exosome biogenesis, for instance, the endosomal sorting complexes required for transport (ESCRT) machinery and ESCRT‐independent pathways, are thoroughly discussed. Looking ahead, future approaches that leverage innovative technologies hold the promise of revolutionizing disease management and improving patient outcomes. [ABSTRACT FROM AUTHOR]

The endocannabinoid system has garnered attention as a potential therapeutic target in a range of pathological disorders. Cannabinoid receptors type 2 (CB2) are a class of G protein‐coupled receptors responsible for transmitting intracellular signals triggered by both endogenous and exogenous cannabinoids, including those derived from plants (phytocannabinoids) or manufactured synthetically (synthetic cannabinoids). Recent recognition of the role of CB2 receptors in fibrosis has fueled interest in therapeutic targeting of CB2 receptors in fibrosis. Fibrosis is characterized by the alteration of the typical cellular composition within the tissue parenchyma, resulting from exposure to diverse etiological factors. The pivotal function of CB2 agonists has been widely recognized in the regulation of inflammation, fibrogenesis, and various other biological pathologies. The modulation of CB2 receptors, whether by enhancing their expression or activating their function, has the potential to provide benefits in numerous conditions, particularly by avoiding any associated adverse effects on the central nervous system. The sufficient activation of CB2 receptors resulted in the complete suppression of gene expression related to transforming growth factor β1 and its subsequent fibrogenic response. Multiple reports have also indicated the diverse functions that CB2 agonists possess in mitigating chronic inflammation and subsequent fibrosis development in various types of tissues. While currently in the preclinical stage, the advancement of CB2 compounds has garnered significant attention within the realm of drug discovery. This review presents a comprehensive synthesis of various independent experimental studies elucidating the pivotal role of identified natural and synthetic CB2 agonists in the pathophysiology of organ fibrosis, specifically in the cardiac, hepatic, and renal systems. [ABSTRACT FROM AUTHOR]

Mentha aquatica L., or water mint, is an important member of the Mentha genus, and has long been used in traditional medicine, mainly to treat respiratory diseases such as the common cold. Nevertheless, although over the years many studies have shown that it's potential grows beyond this use, a review that highlights M. aquatica L.'s true potential is still lacking. Thus, the main purpose of the present article is to provide a thorough and multidisciplinary critical review of M. aquatica L., including its phytochemical characterization, main bioactivities, and current marketed cosmetic products. Many compounds have been identified as part of M. aquatica L. composition, such as terpenes, phenolic acids, phenols, and terpenoids, which have been linked to a vast therapeutic potential, namely anti‐inflammatory, antioxidant, antibacterial, antifungal, antiobesity, and hepatoprotection bioactivities, with additional anticancer potential for several types of tumors (breast, lung, and skin), and psycho and neuroactive potential in depression, or Alzheimer's or Parkinson's disease. Additionally, it has been proven to be suitable for cosmetic application since several cleansing, hydrating, protecting, and/or odor masking products containing it are already available, with the main functions attributed to M. aquatica including refreshing/cooling effects, calming/soothing/relaxing effects, and purifying effects, properties closely related to its anti‐inflammatory and antioxidant bioactivities. Hence, M. aquatica is an extremely versatile plant, with its extracts and essential oils having great therapeutic and cosmetic potential. With many marketed cosmetic products, future studies should focus on this plant's medicinal aspects, so that 1 day it can be part of therapeutic regimens. [ABSTRACT FROM AUTHOR]

A silicon heterojunction (SHJ) solar cell with the attractive and widely used atomic layer deposited (ALD)‐ZnO/n‐CdS/p‐Si configuration is examined in this work to learn more about its electrical properties. Using EIS and SCAPS‐1D, a comprehensive model of the device is created and then simulated. Theoretical aspects of the cell are examined through the use of similar electrical circuit models, focusing on the transmittance spectrum made possible by the ALD‐ZnO layer's low reflectance and high visible transmittance. In this study, the C–V tool is used to study the trap states in the silicon absorber layer under different lighting conditions and wavelengths. The doping concentration and built‐in potential are determined using the Mott–Schottky technique. In addition, the cell's properties are investigated by measuring its G–V, G–F, C–T, and C–F in different real‐world scenarios. As a means of visualizing the electrochemical impedance data, Nyquist plots—sometimes called Cole–Cole plots—are utilized. By utilizing absolute impedance and phase shifts, Bode plots are employed to examine the system's frequency response. Last, the results of the SHJ cell's spectral response measurements are given, which confirm the results of the Nyquist plots. [ABSTRACT FROM AUTHOR]

Aim: Optimal care for patients with kidney failure reduces the risks of adverse health outcomes, including cardiovascular events and death. We evaluated data from the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN‐GKHA) to assess the capacity for quality service delivery for kidney failure care across countries and regions. Method: We explored the quality of kidney failure care delivery and the monitoring of quality indicators from data provided by an international survey of stakeholders from countries affiliated with the ISN from July to September 2022. Results: One hundred and sixty seven countries participated in the survey, representing about 97.4% of the world's population. In countries where haemodialysis (HD) was available, 81% (n = 134) provided standard HD sessions (three times weekly for 3–4 h per session) to patients. Among countries with peritoneal dialysis (PD) services, 61% (n = 101) were able to provide standard PD care (3–4 exchanges per day). In high‐income countries, 98% (n = 62) reported that >75% of centers regularly monitored dialysis water quality for bacteria compared to 28% (n = 5) of low‐income countries (LICs). Capacity to monitor the administration of immunosuppression drugs was generally available in 21% (n = 4) of LICs, compared to 90% (n = 57) of high‐income countries. There was significant variability between and within regions and country income groups in reporting the quality of services utilized for kidney replacement therapies. Conclusion: Quality assurance standards on diagnostic and treatment tools were variable and particularly infrequent in LICs. Standardization of delivered care is essential for improving outcomes for people with kidney failure. [ABSTRACT FROM AUTHOR]

This paper proposes an optimisation method for fabricating composite materials and functionally graded structures. Using the proposed method, 3D printing of copper (Cu)–polyethylene (PE) composite, Al2O3–ZrO2 ceramic composite and functionally graded CuO foams are utilised. This work aims to advance the capabilities of additive manufacturing by leveraging nature‐inspired approaches to create complex, tailored structures with enhanced performance across various industries. The major objective of the proposed method is to reduce the feed rate and increase the airflow rate and airflow temperature for the heat transfer process. Using the proposed technique in the advanced preparation conditions, Cu–PE composites with unreliable Cu substances are fabricated. The PE binder particle is melting as well as forming thick composites by means of soft surfaces. Using the proposed AHO approach, functionally graded materials with common distributions can be efficiently optimised. By then, the proposed model is implemented on the MATLAB platform, and its execution is calculated using the current procedures. The proposed technique displays superior outcomes in all existing methods like wild horse optimiser, particle swarm optimisation and heap‐based optimiser. The proposed method shows a throughput of 57 mm3. The existing method shows the throughput of 32, 27 and 45 mm3. The results show that the proposed method has higher throughput compared with existing methods. [ABSTRACT FROM AUTHOR]

Cancer is highlighted as one of the deadliest diseases globally, with CDK5 identified as a key enzyme in cancer progression. Despite its potential as a therapeutic target, developing CDK5 inhibitors has been challenging. We used multicomplex‐based pharmacophore modeling on CDK5 complexes, identifying hydrophobic groups, hydrogen bond donors, and acceptors as crucial inhibition features. Validated models were used for the virtual screening of drug‐like natural product databases. Thereafter, the screened candidates were selected to study their binding pattern and binding efficiency in the enzyme. Four molecules were shortlisted and analyzed for electrostatic potential (ESP) energy maps. Molecular dynamic simulations and free energy calculations on the docked complexes revealed stable behavior for all, with three (CNP0299652, CNP0362830, and CNP0009633) showing higher Poisson Boltzmann surface area continuum solvation (MM‐PBSA) binding scores than the reference. These candidates demonstrated drug‐like characteristics, crucial amino acid interactions, favorable electron potentials in ESP plots, stable dynamicigher free energy, highlighting their potential as CDK5 inhibitors. [ABSTRACT FROM AUTHOR]

This work aims to target phosphoglycerate dehydrogenase (PHGDH), a promising druggable target, that is overexpressed in various types of cancer. A structure‐based approach was employed to identify novel inhibitors against the enzyme. A common five‐feature pharmacophore model (RRHDA) was constructed using the active site co‐crystalized ligands. These chemical features were responsible for showing inhibition. The generated models were subsequently subjected to the validation method using a test set, receiver‐operator characteristic analysis, enrichment factor, and Güner–Henry studies. The validated models were subjected to the screening of a dataset of natural compounds. The screened unique natural compounds (1795) were further selected for the interaction analysis and study of ligand binding affinity considering the effect of the hydrogen bonding and desolvation and hydrophobic interactions contribution to the binding. The natural compounds which exhibited good ligand binding efficiency were selected and further subjected to pharmacokinetics and pharmacodynamic study. The natural compounds which exhibited good ligand binding efficiency were selected and further subjected to pharmacokinetics and pharmacodynamic study. The finalized complexes were selected for the simulation studies and MM/PBSA‐based binding free energy calculations. This study expands the possibilities for the development of shortlisted molecules as novel anti‐cancer compounds. [ABSTRACT FROM AUTHOR]

Although single‐stage inverters are popular for simpler design they face difficulties in shoot‐through mode operation. Insufficient DC voltage regulation and complicated LC network are principal drawbacks of these topologies. A new split source inverter (SSI) can solve problems with single‐stage inverters. In this paper, SSI replaced the voltage source inverter (VSI) of a shunt active power filter (SAPF) which alleviates power quality (PQ) issues in power system. Furthermore, a VSI‐based SAPF faces challenges to maintain consistent voltage across DC‐link capacitor, exactly compensating current generation, and switching loss reduction in inverter. This study examined efficacy of two inverter‐based SAPFs considering a modified synchronous reference frame approach for generating reference current; fuzzy logic controller for regulating DC‐link voltage; and adaptive fuzzy hysteresis current controller for generating switching pulses. Ideal and non‐ideal sources were considered when running the simulations for various load circumstances. The proposed SSI‐based SAPF with an advanced control approach can eradicate source current harmonics to 0.52% and 0.45% under ideal source conditions, and 0.65% and 0.54% under non‐ideal source conditions for non‐linear loads. Similarly, the ripples in the DC‐link voltage are also reduced to 2–3 V for the ideal case and 4–5 V for non‐ideal case. [ABSTRACT FROM AUTHOR]

2,4‐Thiazolidinedione derivatives represent nitrogen‐containing heterocyclic compounds utilized in type 2 diabetes mellitus management. Recent advances in medicinal chemistry have unveiled diverse therapeutic potentials and structural modifications of these derivatives. This review delves into novel TZD derivatives, encompassing their synthesis, structure‐activity relationships, and pharmacokinetic profiles. Various therapeutic potentials of TZDs are explored, including anticancer, antimicrobial, anti‐inflammatory, antioxidant, anticonvulsant, antihyperlipidemic, anticorrosive, and antitubercular activities. Additionally, it addresses mitigating side effects associated with marketed TZD derivatives such as weight gain, oedema, fractures, and congestive heart failure in type 2 diabetes mellitus management. The review elaborates on in vivo, in vitro, and ex vivo studies supporting different biological activities, alongside predicting ADME and drug‐likeness properties of TZDs. Computational studies are also integrated to elucidate binding modes and affinities of novel TZD derivatives. Furthermore, a plethora of novel TZD derivatives with varied and enhanced therapeutic potentials are presented, warranting further evaluation of their biological activities. [ABSTRACT FROM AUTHOR]

Paediatric phaeochromocytomas and paragangliomas (PPGLs), though rare tumours, are associated with significant disability and death in the most vulnerable of patients early in their lives. However, unlike cryptogenic and insidious disease states, the clinical presentation of paediatric patients with PPGLs can be rather overt, allowing early diagnosis, granted that salient findings are recognized. Additionally, with prompt and effective intervention, prognosis is favourable if timely intervention is implemented. For this reason, this review focuses on four exemplary paediatric cases, succinctly emphasizing the now state‐of‐the‐art concepts in paediatric PPGL management. [ABSTRACT FROM AUTHOR]

This review explores advancements, challenges, and considerations in photocatalytic dye degradation for sustainable wastewater treatment. It highlights smart photocatalyst design, visible‐light‐responsive materials, and co‐catalyst engineering, which enhance system efficacy. Despite environmental concerns, the eco‐friendly aspects of photocatalysis offer a promising alternative to traditional methods. Future perspectives emphasize nanotechnology's role in developing effective photocatalysts and integrating visible‐light and solar‐driven systems to meet sustainability goals. Efforts in co‐catalyst engineering and reactor design aim to optimize processes, addressing kinetic and scalability challenges, while economic research focuses on reducing costs to improve competitiveness. [ABSTRACT FROM AUTHOR]

The debate between patent rights of pharmaceutical firms and the rights of the poor to equal access to health is an old one. The basic purpose of any patent system that grants a temporary monopoly to an innovator is to stimulate innovation and investment in the production of the newly innovated goods and services, which in turn gives supernormal profits to the innovator. However, the equity considerations dictate the spread of this knowledge in the public domain. The dilemma of the patent system is that, in encouraging R&D, it prevents the diffusion of innovation and consequently creates a non‐competitive situation. This paper examines the impact of patent protection on the number of patent filings by the pharmaceutical companies in India after it signed the Trade‐Related Aspects of Intellectual Property Rights (TRIPS) agreement and the trend in research and development expenditure by domestic firms. It questions the basis of this intellectual property right, especially, when a substantial amount of basic research is often carried out in the universities and federal funding is provided at the basic research and development level. It further investigates the success of various flexibilities provided under TRIPS which the Indian Patent Act has used and can potentially use, in comparison to other developed countries, to provide easy access to the medicines. The paper concludes by exploring other options available during public health emergencies and otherwise. [ABSTRACT FROM AUTHOR]

Additive manufacturing of thermoplastic elastomers is challenging using fused deposition modeling due to their high melt viscosity, low column strength, and poor fusion among layers. Solvent‐cast 3D printing (SC‐3DP) is an efficient alternative to successfully 3D print such materials. However, selection of suitable 3D printing parameters is crucial to realize parts with optimum physicomechanical properties. In this work, statistical modeling and SC‐3DP parameter optimization for styrene–ethylene–butylene–styrene (SEBS) block copolymer were performed. The effect of 3D printing process parameters on shrinkage, relative density, and tensile strength was analyzed using response surface methodology. Experiments were planned as per central composite design and analysis of variance was performed to evaluate the significant parameters. SEBS content in the polymer solution significantly affected the shrinkage of SC‐3DP samples. Moreover, relative density and tensile strength were significantly affected by print speed and layer height. A significant interaction between print speed and layer height was also noticed for tensile strength and relative density of printed samples. Multi‐objective optimization using genetic algorithm was also performed to minimize shrinkage and maximize relative density and tensile strength. Finally, a case study was conducted comparing the physicomechanical properties of SC‐3DP samples printed at optimized process parameters and compression molded samples. Highlights: Statistical models were developed using response surface methodology.Genetic algorithm based multi‐objective optimization was performed.Optimum solvent‐cast 3D printing (SC‐3DP) process parameters were determined. [ABSTRACT FROM AUTHOR]

The city of Mumbai is engaged in large‐scale urban restructuring efforts. Foundational to these is the demolition of many of the city's informal settlements and the relocation of residents to newly built housing complexes. Often discussed in terms of dispossession, this process is also one of formalization, with spatial, economic, cultural and sociopolitical implications. This article focuses on formalization's sociopolitical dimension, entailing the registration of residents and the establishment of formal governance provisions and new citizenship expectations. The provision of formal housing and recognized housing tenure has, designedly, been coupled with the establishment of official self‐governance mechanisms leading to new civic responsibilities and reshaping the experience of citizenship among former slum dwellers. We explore these governance arrangements, the interaction between formality and informal governance processes and how these arrangements impact residents' perspectives on citizenship. We also identify several challenges to effective self‐governance and the ways in which formal and informal processes shape residents' experiences of community life, citizenship and urban integration. While residents have benefited from some aspects of formalization (e.g. indoor plumbing and codified tenure rights), it has brought additional burdens, and the challenges of self‐governance have, for many relocatees, reproduced a kind of marginalized citizenship within formal structures. [ABSTRACT FROM AUTHOR]

The growing informal nature of employment in the gig economy does not only merely provide employment for many but also causes exploitation, insecurity, and exclusion from social security because of its informal status. Workers in gig work often go through long working hours, low wages, fear of losing their job, and insecurity which result in their precarious life condition. They experience vulnerabilities related to their employment, residency status, and unfamiliarity with local frameworks—labor law, health, and safety hazards at work which certainly highlights precarious life situations. Besides precarity, gig workers from poor socio‐economic backgrounds often experience discrimination and exclusion because of their social positioning in society. Therefore, the article tries to unfold their experiences of exploitation and insecurity, struggles, and challenges. Further, the article also examines the contemporary agitation and resistance of gig workers against the exploitative policies of aggregators and state measures to address the problem of gig workers in India. [ABSTRACT FROM AUTHOR]

The article examines the impact of the IL-4-IL-4Rα axis on olfactory neuroimmune signaling and its role in inducing loss of smell. Through studies on mice and human translational data, the research reveals that IL-4 disrupts olfactory sensory neurons' responsiveness to odors, leading to neuroinflammation and immune responses in the olfactory epithelium. The findings suggest that IL-4-IL-4Rα signaling mediates neuroimmune crosstalk, driving olfactory dysfunction in conditions like chronic rhinosinusitis with nasal polyps. The study, conducted by researchers from Sanofi and Regeneron Pharmaceuticals, provides insights into potential therapeutic strategies for addressing olfactory dysfunction and related conditions. [Extracted from the article]

India has observed increasingly persistent heat extremes in recent decades. North‐Central India, a highly populated region prone to heatwaves, has experienced record maximum temperatures (> ${ >} $48°C) during the pre‐monsoon season. While studies have shown positive trends in heatwaves due to rising air temperature, we identify a shift in pre‐monsoon mean daily maximum temperature over North‐Central India, resulting in an increase in temperature by 0.7°C post‐1998. The jump in temperature is associated with a northward migration of the subtropical westerly jet since 1998. We find that the meridional shift in the subtropical westerly jet explains more than 25% of the variability in heatwave characteristics over North‐Central India, implying that the increase in heatwaves post‐1998 is associated with a northward shift of the jet. These findings highlight that the exacerbation of heatwaves in North‐Central India is driven by atmospheric dynamical changes triggered by a regime shift, further compounded by global warming. Plain Language Summary: In recent years, India has been experiencing more frequent and intense heatwaves, especially over the North‐Central region. We found that since 1998, the temperature over North‐Central India has increased by about 0.7°C during the pre‐monsoon season. This increase appears to be due to the northward displacement of the band of strong upper tropospheric winds, known as the subtropical westerly jet. The shifting in the jet stream is making the heatwaves occur more frequently and last longer, exacerbating heatwave risks in this densely populated region. Overall, our findings emphasize the importance of understanding how winds have changed in the atmosphere due to natural variability or climate change and their contribution to the intensification of heatwaves in the region. Such understanding has potential applications in forecast of heatwaves in India. Key Points: The pre‐monsoon season witnessed a regime shift in 1998, resulting in a rise in temperature over North‐Central IndiaThe subtropical westerly jet index positively correlates with the heatwave characteristics, explaining more than 25% of heatwave variabilityThe increase in heatwaves post‐1998 can be partially attributed to the northward shifting of the subtropical westerly jet [ABSTRACT FROM AUTHOR]

Objective. The red rhizome of Angiopteris helferiana has been used widely to treat muscle fatigue, bone pain, and skin infection in Nepal. However, scientific evidence for its bioactive compounds and their bioactivities was lacking till January, 2024. Therefore, we investigated to validate and advance the further use and development. Methods. Column chromatography, including MCI gel CHP20P, Sephadex LH‐20, ODS, and Silica gel, was used for the isolation of compounds from 70% methanol extract of A. helferiana rhizomes. The isolated compounds were evaluated for their TLC‐based antioxidant and antibacterial activity against Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa by adopting the agar well diffusion protocol. Furthermore, in silico molecular docking against the penicillin binding protein of E. coli (PBP1b, PBP2, and PBP3 TPd) and ADME toxicity of the isolated compounds was predicted. Results and Discussion. Angiopteroside (1) and osmundalactone (2) were isolated for the first time from the red rhizomes of A. helferiana. The structure of the isolated compounds was elucidated on the basis of spectroscopic (1H‐, 13C‐, and 13C/DEPT‐NMR) and spectrometric (LC MS/ESI and IR) analyses and comparison with reported literature. Both compounds were inactive towards DPPH scavenging activity. Compound 1 showed poor inhibitory activity against E. coli, with inhibition zone range of 2–7 mm. However, both isolated compounds were found to be resistant against S. aureus, K. pneumonia, and P. aeruginosa. Based on in silico molecular docking forecasting, compound 1 revealed the good binding affinity with PBP1b (−6.5 kcal/mol), PBP2 (−5.8 kcal/mol) and PBP3 TPd (−6.1 kcal/mol) compared to positive control meropenem with PBP1b (−6.6 kcal/mol), PBP2 (−6.9 kcal/mol), and PBP3 TPd (−6.6 kcal/mol). Similarly, compound 2 showed weak preference for PBP1b (−4.3 kcal/mol), PBP2 (−4.4 kcal/mol), and PBP TPd (−4.5 kcal/mol). Compounds 1 and 2 were predicted to be safe in terms of hepatotoxicity, cytotoxicity, mutagenicity, and carcinogenicity, with a potential to induce nephrotoxicity similar to that of meropenem. Conclusion. This study successfully isolates two lactones with antibacterial properties and inspires the researcher to further research, development, and formulation. [ABSTRACT FROM AUTHOR]

The one‐step green synthesis of wide band gap zinc oxide@zinc sulfide (ZnO@ZnS) core–shell nanostructures offers promising prospects in wastewater treatment. These nanostructures exhibit a porous nature crucial for effective dye adsorption, as evidenced by Brunauer‐Emmett‐Teller (BET) and microscopic characterization. The synthesized material demonstrates high stability and minimal agglomeration, verified through BET analysis and zeta potential measurements. X‐ray powder diffraction confirms the presence of ZnO and ZnS phases. Transmission electron microscopy reveals the development of porous nanorods on the core surface, maximizing the surface area for dye adsorption. In wastewater treatment, the nanostructures exhibit notable performance, degrading 90% of malachite green and 50% of rhodamine B dyes within 120 min under normal conditions. Detailed discussions delve into the degradation mechanism, elucidating the major species responsible for the process. This study underscores the potential of ZnO@ZnS nanostructures in efficient organic pollutant removal, marking a significant advancement in environmental remediation. [ABSTRACT FROM AUTHOR]

The need to address antimicrobial resistance (AMR) through a One Health (OH) approach is now well recognized. There is, however, limited guidance on how AMR surveillance should be implemented across sectors to generate meaningful AMR and AMU data for decision‐making. Using a sympatric approach to cross‐sector sample collection, Nepal adopted the WHO extended‐spectrum beta‐lactamase (ESBL)–producing Escherichia coli (E. coli) Tricycle Project as a step toward OH surveillance for assessing the prevalence of ESBL‐producing E. coli across human, veterinary, and environment sectors. This involved a three‐stage approach: identification of human hotspots (Stage 1) and sample collection sites for poultry (Stage 2) and wastewater (Stage 3). A total of 53 blood cultures from patients with bloodstream infections (BSIs), 100 stool samples from healthy pregnant women, 220 poultry ceca from slaughterhouses and live markets, and 48 wastewater samples were processed for bacterial culture and analyzed for the presence of ESBL‐producing E. coli. The prevalence of ESBL‐producing E. coli among isolated E. coli was the highest in wastewater samples (91%) followed by human BSIs (49%), poultry (38.6%), and fecal carriage isolates from healthy pregnant females (15%). A statistically significant association was seen in the prevalence of multidrug resistance among ESBL producers (52%) and nonproducers (26%). ESBL‐producing E. coli was detected in all wastewater samples tested except for the upstream river. The findings of the study showed a high prevalence of ESBL‐producing E. coli in samples from all three sectors and provided baseline data based upon which strategies for the safe disposal of communal and hospital waste, integrated AMR surveillance, and control strategies could be planned and implemented. [ABSTRACT FROM AUTHOR]

The emergence of K‐ion batteries (KIBs) heralds a promising frontier in energy storage technology, offering the potential for high specific energy density, long cycle life, and robust power capabilities, all while utilizing the abundant resources of potassium. In response to the challenges posed by synthetic intricacies related to K‐based cathodes, the effort is directed toward employing soft chemistry (chimie douce) method to unveil a hitherto‐unknown P2‐type K1/3Co1/3Mn2/3O2 (KCM) layered oxide cathode for KIBs. Comprehensive analysis using diffraction, microscopy, and spectroscopy tools reveals the ion exchange reaction proceeds through overlay ordered structure formation mechanism. The as‐prepared KCM material serves as a ≈2.9 V positive K+ insertion host. Further, it showcases an exceptional structural reversibility, robust cycling performance with ≈100% coulombic efficiency even after 100 cycles, and maintaining electrochemical stability even at elevated temperature (c.a. 40° and 50 °C). The KCM cathode exhibits in‐plane Co–Mn ordering and solid‐solution redox mechanism during (de)potassiation. Combining first‐principles calculations with experimental tools, this research demonstrates the efficacy of ambient ion‐exchange route in stabilizing promising cathode materials for KIBs. This innovative synthetic approach not only streamlines synthetic complexities, but also holds significant implications for the advancement of KIB technology for stationary energy storage. [ABSTRACT FROM AUTHOR]

Research is about an individual's intellectual acumen and rationality, and inter‐researcher collaboration capability magnifies the outcomes. Despite common belief, there exist fundamental asymmetries in the goals, orientations and expectations among the research collaborators. Seldom studied in‐depth and empirically validated, the challenges and barriers faced by early‐career researchers (ECRs) in social sciences are crucial to understand. In this study, we aim to identify, categorize and rank the order of priority of the research collaboration barriers and their sub‐barriers. This analysis highlights which barrier is likely to impact the research collaboration outcome more as compared to other barriers, as seen through the pairwise comparison. We contribute to the literature on research collaborations by providing a much‐needed assessment of the barriers faced by ECRs in social sciences to develop a nuanced understanding of the dynamics within collaboration research. Key barriers identified and explored in this research relate to research design, interpersonal and interprofessional relationships, team‐level dynamics, spatial and temporal factors, cultural differences and institutional variables. The fuzzy AHP tool was used to prioritize and rank the barriers, check the consistency ratio and then perform the sensitivity analysis. Research design barriers emerged as the most challenging barrier to research collaborations, implying researchers place huge emphasis on the compatibility of research goals, objectives, paradigms and perspectives. The study provides insights for individuals/institutions leading and managing research collaborations into improving the collaborative dynamics in social sciences. [ABSTRACT FROM AUTHOR]

Background Objectives Methods Results Discussion Conclusion During the coronavirus pandemic, misinformation was circulated through technology and social media on a large scale. Since people rely on media to keep connected and informed, misinformation can prevent them from staying safe.To examine the quality of information reaching Pakistanis, the effect of information/misinformation on people's perception, and its relationship with risky health behaviours in different demographical groups.A community sample of N= 103 Pakistanis was assessed using a mixed‐method cross‐sectional survey research design to investigate their sources of knowledge/information, perceptions of coronavirus‐related facts, and risky health behaviours.Content analysis of the material that participants read/watched indicated the possible effect of media on people's perception of COVID‐19. Specific demography (e.g., increasing age) and people's tendency to believe misinformation/information may indicate risky health behaviours pertaining to coronavirus infection.Findings showed how the models considered (social cognitive theory, biological warfare conspiracy theory, theory of planned behaviour, protection motivation theory, the health belief model, and biopsychosocial model) may be relevant to examination of the effects of misinformation on different demographic groups.The findings and models need to be verified on larger, more representative samples of Pakistanis using a large‐scale survey based on the insights obtained from this pilot study. [ABSTRACT FROM AUTHOR]

Background: Manganese (Mn) deficiency due to nutrient mining by high yielding cereal–cereal cropping patterns and forgetfulness of Mn fertilizer applications becomes potential challenge in crop production. Aim: Nano‐enabled Mn fertilizers can be safer and more nutrient efficient than conventional Mn fertilizers (nutrient use efficiency ≈ 1%–3%). However, studies about nano‐Mn fertilizer synthesis and their behaviour in soil–plant system are rare. Methods: In this study, two novel nano‐Mn fertilizers, that is nano‐MnO2 (NMO) and manganese nanoclay polymer composites (Mn‐NCPC), were synthesized, characterized (dynamic light scattering, X‐ray diffraction, Scanning electron microscopic and energy‐dispersive X‐ray, Fourier transform infrared spectroscopy etc.) and investigated for their impact on growth, yield and nutrient acquisition by wheat crop (Triticum aestivum L., variety HD‐2967) in a pot culture experiment. Treatment comprised 25%, 50% and 100% of recommended dose of Mn (RDMn) through NMO along with 100% RDMn through MnSO4·H2O (MS). Effect of exposure route was also investigated using foliar spray of NMO at tillering stage. Mn‐NCPC was found to be most efficient Mn fertilizer in terms of yield, Mn uptake and use efficiency by wheat crop. Results: Nano‐sized formulations improved the solubility of Mn in soil due to its higher active surface area (NMO) and slow‐release behaviour (Mn‐NCPC); thus, minimal losses happened due to the fixing of Mn in oxide/hydroxide forms. Application of 25% RDMn through NMO fertilizers maintained equitant diethylenetriamine pentaacetate Mn content to 100% RDMn through MnSO4·H2O. Mn‐NCPC stimulated the soil enzymatic activities, namely dehydrogenase, acid–alkaline phosphatase activities. Mn‐NCPC and NMO at 100% RDMn recorded 3.51% and 5.20% improvement in grain yield, respectively, when compared to MnSO4·H2O 100%. Conclusions: Mn fertilizer doses can be reduced up to 25% of RDMn when applied through NMO or Mn‐NCPC fertilizers. However, effects of Mn‐NCPC and NMO need to be critically evaluated in long‐term field experiments in various cropping systems especially under cereal–cereal sequences for economic profitability and wide‐scale farmer's adaptability. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged as the most common form of dementia in the elderly. Several pathological hallmarks have been identified, including neuroinflammation. A comprehensive insight into the underlying mechanisms that can fuel the development of novel therapeutic approaches is necessary because of the alarmingly rapid increase in the frequency of incidence. Recently, NLRP3 inflammasome was identified as a critical mediator of neuroinflammation. Activation of nucleotide‐binding domain (NOD)‐like receptor protein 3 (NLRP3) inflammasome by amyloid, neurofibrillary tangles, impaired autophagy and endoplasmic reticulum stress, triggers the release of pro‐inflammatory cytokines such as IL‐1β and IL‐18. Subsequently, these cytokines can promote neurodegeneration and cognitive impairment. It is well established that genetic or pharmacological ablation of NLRP3 alleviates AD‐related pathological features in in vitro and in vivo models. Therefore, several synthetic and natural compounds have been identified that exhibit the potential to inhibit NLRP3 inflammasome and alleviate AD‐associated pathology. The current review article will highlight the various mechanisms by which activation of NLRP3 inflammation occurs during Alzheimer's disease, and how it influences neuroinflammation, neurodegeneration and cognitive impairment. Moreover, we will summarise the different small molecules that possess the potential to inhibit NLRP3 and can pave the path for developing novel therapeutic interventions for AD. [ABSTRACT FROM AUTHOR]

In the quest of finding the minimum ceria doping for a stabilized zirconia matrix, we report a remarkable structure–property correlation for a high (> 99%) density, fine grained (∼100 nm), fully phase‐pure (confirmed via both slow scan X‐ray diffraction and Raman spectroscopy) tetragonal 10 mol.% CeO2‐doped zirconia ceramics (10Ce‐TZP). A starting near spherical, ultrafine (∼7 nm) powders with high surface area (∼170 m2/g) ensured the conventional pressureless sintering at 1150°C without the need of any additives, binders, and/or sintering aid to achieve this high density. No monoclinic phase was traced at the end of the low‐temperature degradation test for 100 h in boiling water; negligible (∼5% monoclinic phase) amounts showed up in the thermal quenching tests. The sintered 10Ce‐TZP ceramic recorded comparable/better hardness and indentation toughness value with respect to higher (i.e., 12 mol.%) ceria doped‐zirconia systems. For the first time, nanograined translucent 10Ce‐TZP ceramic portrayed a remarkable transmittance of ∼38% at 600 nm wavelength for 0.6 mm thick pellet. [ABSTRACT FROM AUTHOR]

The myo‐inositol‐1‐phosphate synthase (MIPS) catalyses the biosynthesis of myo‐inositol, an important sugar that regulates various physiological and biochemical processes in plants. Here, we provide evidence that host (SlMIPS1) and pathogen (Rs_MIPS) myo‐inositol‐1‐phosphate synthase (MIPS) genes are required for successful infection of Rhizoctonia solani, a devastating necrotrophic fungal pathogen, in tomato. Silencing of either SlMIPS1 or Rs_MIPS prevented disease, whereas an exogenous spray of myo‐inositol enhanced disease severity. SlMIPS1 was upregulated upon R. solani infection, and potentially promoted source‐to‐sink transition, induced SWEET gene expression, and facilitated sugar availability in the infected tissues. In addition, salicylic acid (SA)‐jasmonic acid homeostasis was altered and SA‐mediated defence was suppressed; therefore, disease was promoted. On the other hand, silencing of SlMIPS1 limited sugar availability and induced SA‐mediated defence to prevent R. solani infection. Virus‐induced gene silencing of NPR1, a key gene in SA signalling, rendered SlMIPS1‐silenced tomato lines susceptible to infection. These analyses suggest that induction of SA‐mediated defence imparts disease tolerance in SlMIPS1‐silenced tomato lines. In addition, we present evidence that SlMIPS1 and SA negatively regulate each other to modulate the defence response. SA treatment reduced SlMIPS1 expression and myo‐inositol content in tomato, whereas myo‐inositol treatment prevented SA‐mediated defence. We emphasize that downregulation of host/pathogen MIPS can be an important strategy for controlling diseases caused by R. solani in agriculturally important crops. [ABSTRACT FROM AUTHOR]

The Puumala orthohantavirus is present in the body of the bank vole (Myodes glareolus). Humans infected with this virus may develop hemorrhagic fever accompanying renal syndrome. In addition, the infection may further lead to the failure of an immune system completely. The present study aimed to propose a possible vaccine by employing bioinformatics techniques to identify B and T‐cell antigens. The best multi‐epitope of potential immunogenicity was generated by combining epitopes. Additionally, the linkers EAAAK, AAY, and GPGPG were utilized in order to link the epitopes successfully. Further, C‐ImmSim was used to perform in silico immunological simulations upon the vaccine. For the purpose of conducting expression tests in Escherichia coli, the chimeric protein construct was cloned using Snapgene into the pET‐9c vector. The designed vaccine showed adequate results, evidenced by the global population coverage and favorable immune response. The developed vaccine was found to be highly effective and to have excellent population coverage in a number of computer‐based assessments. This work is fully dependent on the development of nucleoprotein‐based vaccines, which would constitute a significant step forward if our findings were used in developing a global vaccination to combat the Puumala virus. [ABSTRACT FROM AUTHOR]

The technological revolutions in computers and the advancement of high‐throughput screening technologies have driven the application of artificial intelligence (AI) for faster discovery of drug molecules with more efficiency, and cost‐friendly finding of hit or lead molecules. The ability of software and network frameworks to interpret molecular structures' representations and establish relationships/correlations has enabled various research teams to develop numerous AI platforms for identifying new lead molecules or discovering new targets for already established drug molecules. The prediction of biological activity, ADME properties, and toxicity parameters in early stages have reduced the chances of failure and associated costs in later clinical stages, which was observed at a high rate in the tedious, expensive, and laborious drug discovery process. This review focuses on the different AI and machine learning (ML) techniques with their applications mainly focused on the pharmaceutical industry. The applications of AI frameworks in the identification of molecular target, hit identification/hit‐to‐lead optimization, analyzing drug–receptor interactions, drug repurposing, polypharmacology, synthetic accessibility, clinical trial design, and pharmaceutical developments are discussed in detail. We have also compiled the details of various startups in AI in this field. This review will provide a comprehensive analysis and outline various state‐of‐the‐art AI/ML techniques to the readers with their framework applications. This review also highlights the challenges in this field, which need to be addressed for further success in pharmaceutical applications. [ABSTRACT FROM AUTHOR]

We examine the association between the social capital—social norms that encourage altruism and discourage opportunism—in the state of the firm's headquarters and the acquisitions it makes. We find that the cumulative abnormal return around an acquisition announcement is high when an acquirer is headquartered in a high social capital state in the United States. This effect is robust and incremental to the effect of a firm's corporate social responsibility (CSR) ratings and economically comparable to the effect of corporate governance. The effect of social capital is stronger for firms that have lower CSR ratings, which indicates social capital may act as a substitute for CSR. An additional analysis shows that social capital's effect is stronger in a subsample of firms with weak corporate governance. Acquirers from states with high social capital also demonstrate less hubris in acquiring targets than those from states with low social capital as the evidence of lower bid premiums indicates. Overall, our results show that the social norms that social capital measures mitigate potential agency problems in acquisitions by inducing managers to honor their obligations to shareholders. [ABSTRACT FROM AUTHOR]

Interaction between the cold rolling oil and substrate at the roll bite has always intrigued the tribologists. In plant conditions, it has been observed that occurrences of surface defects on cold‐rolled FHCR coils increase with the ageing of cold rolling emulsion. In this study, the rolling oil was aged at different lab conditions to replicate 6 and 11 months of rolling oil ageing from a particular cold rolling mill. The studies indicated an increase in acid number of the oil. Tribological studies indicated an increase in CoF along with an increase in wear phenomenon on the substrate. The removability of the surface oil becomes difficult with ageing which could lead to potential surface oil residues remaining on the strip after degreasing, resulting in surface defects and dirty coils after annealing. Deterioration in anti‐stain property is also observed as ageing progresses. The deterioration in performance is mainly governed by the depletion in additives and generation of free fatty acids within the rolling oil bath. Proper maintenance of the bath ensures lesser defect formation. [ABSTRACT FROM AUTHOR]

2D simulations have been performed to investigate flow regimes in a flow‐focusing geometry by changing the dispersed phase and continuous phase velocities. The dispersed phase is polydimethylsiloxane (PDMS), and the continuous phase is water. Simulations have been performed in a range of oil–water viscosity ratio μoμw from 3 to 50, and interfacial tension ranges from 0.0118 to 0.002 N/m. The walls of the microchannel are considered to be poly(methyl methacrylate) (PMMA) surfaces. The contact angle (θ) of an oil droplet in the presence of water wetting the PMMA surface is 140°. Our study observed two types of flow regimes, namely dripping and jetting, by changing the dispersed phase and continuous phase velocities. The sequential time steps of void fraction contour have been presented to explore the droplet formation mechanism. The droplet pinch‐off time and jet growth time have been calculated for the dripping and jetting regime, respectively. The outcomes are summarized in the form of a flow pattern map at a viscosity ratio of 12 and interfacial tension of 0.0118 N/m, which shows the transition boundary between dripping and jetting phenomena. The simulated transition boundary agrees well with the analytical solution available in the literature. The effect of oil–water viscosity ratio and interfacial tension on droplet size is also investigated. These findings will help understand different flow regimes and their transition in a flow focusing geometry and will directly apply to microfluidic platform‐based devices. [ABSTRACT FROM AUTHOR]

Background and aims: A 12‐week placebo‐controlled, sequential parallel Accelerated Development of Additive Pharmacotherapy Treatment for Methamphetamine Use Disorder (ADAPT‐2) trial evaluated the effects of extended‐release injectable naltrexone plus extended‐release oral bupropion (NTX + BUPN) on methamphetamine (MA) use over two stages. This study reports on the previously unpublished stage 2 MA use in participants randomized at stage 1 to receive NTX + BUPN through both stages compared with those assigned to placebo. Design: This is a secondary analysis of the US National Institute on Drug Abuse (NIDA) ADAPT‐2 network trial. Setting: The parent ADAPT‐2 trial was carried out across multiple NIDA Clinical Trials Network (CTN) sites in the United States. Participants: This analysis includes 403 people with MA use disorder who participated in the ADAPT‐2 CTN trial. Intervention and comparator: NTX + BUPN was compared with placebo over the course of the trial. Measurement MA use was measured by urine drug screens conducted twice weekly for 12 weeks, then once in week 13 and once in week 16 post‐treatment follow‐up. Findings Participants on NTX + BUPN in stage 1 showed an additional 9.2% increase [95% confidence interval (CI), 0.09%–17.9%, P = 0.038] during stage 2 in their probability of testing negative for MA, with a total increase of 27.1% (95% CI, 13.2%–41.1%, P < 0.001) over the full 12 weeks of treatment. In contrast, participants on placebo in both stages increased in probability of testing MA‐negative by a total of 11.4% (95% CI, 4.1%–18.6%, P = 0.002) over all 12 weeks. The 12‐week increase among participants on NTX + BUPN was significantly greater—by 15.8% (95% CI, 4.5%–27.0%, P = 0.006)—than the increase among those on placebo. Conclusion: For people with methamphetamine (MA) use disorder receiving treatment with extended‐release injectable naltrexone plus extended‐release oral bupropion (NTX + BUPN), continued treatment with NTX + BUPN after 6 weeks is associated with additional reductions in MA use up to 12 weeks. [ABSTRACT FROM AUTHOR]

Summary: Developing early maturing lentil has the potential to minimize yield losses, mainly during terminal drought. Whole‐genome resequencing (WGRS) based QTL‐seq identified the loci governing earliness in lentil. The genetic analysis for maturity duration provided a good fit to 3:1 segregation (F2), indicating earliness as a recessive trait. WGRS of Globe Mutant (late parent), late‐flowering, and early‐flowering bulks (from RILs) has generated 1124.57, 1052.24 million raw and clean reads, respectively. The QTL‐Seq identified three QTLs (LcqDTF3.1, LcqDTF3.2, and LcqDTF3.3) on chromosome 3 having 246244 SNPs and 15577 insertions/deletions (InDels) and 13 flowering pathway genes. Of these, 11 exhibited sequence variations between bulks and validation (qPCR) revealed a significant difference in the expression of nine candidate genes (LcGA20oxG, LcFRI, LcLFY, LcSPL13a, Lcu.2RBY.3g060720, Lcu.2RBY.3g062540, Lcu.2RBY.3g062760, LcELF3a, and LcEMF1). Interestingly, the LcELF3a gene showed significantly higher expression in late‐flowering genotype and exhibited substantial involvement in promoting lateness. Subsequently, an InDel marker (I‐SP‐383.9; LcELF3a gene) developed from LcqDTF3.2 QTL region showed 82.35% PVE (phenotypic variation explained) for earliness. The cloning, sequencing, and comparative analysis of the LcELF3a gene from both parents revealed 23 SNPs and InDels. Interestingly, a 52 bp deletion was recorded in the LcELF3a gene of L4775, predicted to cause premature termination of protein synthesis after 4 missense amino acids beyond the 351st amino acid due to the frameshift during translation. The identified InDel marker holds significant potential for breeding early maturing lentil varieties. [ABSTRACT FROM AUTHOR]

Wind energy has gained tremendous attention recently due to its abundance potential and to obviate the adverse impacts of fossil fuel consumption. However, the efficient development and operation of wind energy systems require precise and accurate wind speed prediction. To fulfill this aim, machine learning algorithms have shown its prowess in accurately predicting the wind speed and this study proposes an interpretable stacked ensemble with ridge regressor utilizing ML algorithms such as catboost (CB), gradient boost (GB), multilayer perceptron (MLP), and random forest (RF) as a base model. The base models' estimations are integrated by applying a ridge regressor to enhance the accuracy of wind speed estimation. The dataset consists of 87 600 samples from which 80% samples are used for training. The proposed approach provides interpretability of the prediction results through Shapley additive explanations and feature importance analysis. The result of the proposed method is calculated by comparing the estimation outcomes with each model such as CB, GB, MLP, and RF in terms of error metrics such as root mean squared error (RMSE) and mean absolute error (MAE). The proposed model outperforms the others due to a reduction of error in RMSE by 19.89% and MAE by 24% respectively. [ABSTRACT FROM AUTHOR]

The present review shows metal‐catalyzed oxidative C(sp3)‐H/C(sp2)‐H bond functionalization of 1,4‐benzoxazinones by utilizing various substrates such as indoles, phosphites or phosphine oxides, malonate esters, and resorcinol, which lead to the formation of new C−C or C−P bonds. The metal catalysts used for these couplings include Fe, Cu, Ag, and Ru. This follows a strategy involving either the one‐electron oxidation process (OEO), ball milling technique, or photocatalytic process. The synthesized products in this method show usefulness in natural products, materials, agriculture, and medicinal chemistry. [ABSTRACT FROM AUTHOR]

Background. The global presence of high blood pressure and depression poses a significant public health threat, particularly in emerging nations. High blood pressure and depression are inevitable among the working population of Ghana, and it is crucial to recognize the potential influence of these conditions on the working‐age population. Materials and Methods. The study analyzed the risk factors associated with high blood pressure and depression among the working population of Ghana. The data in this study were drawn from Wave 1 data of the Study on Global Ageing and Adult Health (SAGE) survey, which was conducted by World Health Organization (WHO) in Ghana from January 2007 to December 2008. A longitudinal survey under the banner of SAGE was conducted. The study used 2681 participants aged 18–60 years. We modeled high blood pressure using logistic regression and depression with the proportional odds model of ordinal logistic regression. Results. The study revealed that the prevalence of depression among the working‐age population was 42.5%, whereas that of high blood pressure was 48.7%. The result also showed that males have a lower risk of developing high blood pressure and depression (OR = 0.851 and OR = 0.658, respectively) compared with females. Also, older adults (40–60 years) have a higher risk of developing high blood pressure and depression (OR = 1.992 and OR = 2.334, respectively) compared with younger adults. Other risk factors associated with high blood pressure include diabetes (2.107), depression, and weight. Last, alcohol intake (1.502), tobacco intake (1.279), and high blood pressure were found to be other risk factors associated with depression. Conclusion. The prevalence of depression and high blood pressure is high among the working population of Ghana. There is therefore the need to incorporate health awareness programs on these topics. [ABSTRACT FROM AUTHOR]

1,4,5,8‐Tetrafluoroacridine was successfully synthesized from 1,4,5,8‐tetrafluoroacridone through transfer hydrogenation using an in‐house ruthenium pincer catalyst followed by in situ dehydration. The synthetic protocol involves the copper‐catalyzed coupling of 2‐amino‐3,6‐difluorobenzoic acid 1 and 1,4‐difluoro‐2‐iodobenzene 2 to obtain 3 followed by cyclization using polyphosphoric acid to get the 1,4,5,8‐tetrafluoroacridone 4. Common synthetic strategies for converting 4 to the 1,4,5,8‐tetrafluoroacridine 5 were unsuccessful and the transfer hydrogenation approach proved to be most fruitful. 1,4,5,8‐Tetrafluoroacridone 4 can be N‐methylated to give 9. The investigation into the photophysical properties of 4, 5, and 9 revealed that the average photoluminescence (PL) lifetime of the acridine derivatives was longer in the aqueous medium than in ethanol and methanol, indicating the influence of the solvent environment on the excited‐state dynamics. To assess their potential therapeutic applications, the cytotoxic activity of these compounds was evaluated against AGS and IMR‐32 cells, and compound 9 showed significant activity. The addition of methyl group to the acridone was found helpful in enhancing the solubility and biological activity. [ABSTRACT FROM AUTHOR]

Developing earth‐abundant low‐cost electrocatalysts is of prime research interest towards the need for clean energy technology, such as water‐splitting reactions. Herein, we have explored the electrocatalytic activity of the double perovskite‐based strontium cobalt molybdenum oxide (SCMO) towards water‐splitting reactions, both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), in harsh alkaline condition (1 M KOH). Prepared by scalable autocombustion synthesis, the as‐synthesised bulk SCMO perovskite exhibited impressive electrocatalytic performance attributed to its substantial electrochemical active surface area, measured at 26.3 cm2. For the OER, it exhibited an overpotential of 350 mV with a Tafel slope value of 76 mV/dec. Concurrently, it showed proficient activity in the HER, revealing an overpotential of 270 mV and a Tafel slope of 112 mV/dec. Further, this perovskite material was stable during continuous electrocatalysis over a 24 h period in harsh alkaline media with a negligible increase in observed overpotential value. The electronic density of states confirmed that the Co plays a pivotal role in enhancing electrocatalytic activities. This is achieved by a substantial reduction in the band gap and enhancement of the d‐band centre to an optimal level, rendering the system more favourable for electrocatalytic reactions. Our study contributes essential insights to the advancement of the design and utilization of perovskite‐based catalysts in the realm of sustainable energy technologies. [ABSTRACT FROM AUTHOR]