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The article discusses the 2023 Consensus statement on doxycycline prophylaxis (doxy-PEP) for the prevention of syphilis, chlamydia, and gonorrhea among gay, bisexual, and other men who have sex with men (GBMSM) in Australia. It highlights the potential benefits of doxy-PEP in reducing syphilis incidence but raises concerns about increasing antimicrobial resistance (AMR) and the need for effective monitoring of doxy-PEP use. The article compares doxy-PEP to HIV pre-exposure prophylaxis (PrEP) and emphasizes the differences in effectiveness and potential risks. It also discusses the impact of doxy-PEP on antimicrobial stewardship, resistance, and the microbiome. The article concludes by suggesting that caution should be exercised in supporting and implementing doxy-PEP and recommends comprehensive counseling and antimicrobial stewardship programs. The text discusses opportunities to enhance surveillance of sexually transmitted infections (STIs), antimicrobial resistance (AMR), and antimicrobial use. The authors support nine recommendations for research, guidelines, and policy, including the need for adequate funding and monitoring of AMR. They suggest implementing standardized data collection methods and interoperable systems to improve understanding of the drivers of resistance. The authors also emphasize the importance of access to STI testing, including AMR testing, and the need for comprehensive surveillance systems to monitor the impact of doxy-PEP use. [Extracted from the article]

Background: Coffee is one of the most consumed beverages in the world. Containing an abundance of bioactive molecules including polyphenols and flavonoids, the constituents of this beverage may exert antiproliferative, antioxidant and anti‐inflammatory effects. Methods: We conducted a systematic review to summarise the available evidence on the anticancer effects of coffee constituents and their potential therapeutic use for oral squamous cell carcinoma (OSCC). Studies were identified through a comprehensive search of OVID MEDLINE, OVID EMBASE and Web of Science, including articles from any year up to 15 May 2023. Results: Of the 60 reviewed papers, 45 were in vitro, 1 was in silico and 8 were in vivo exclusively. The remaining studies combined elements of more than one study type. A total of 55 studies demonstrated anti‐proliferative effects, whilst 12 studies also investigated migration and invasion of neoplastic cells. The constituents studied most frequently were quercetin and epigallocatechin gallate (EGCG), demonstrating various cytotoxic effects whilst also influencing apoptotic mechanisms in cancer cell lines. Dose‐dependent responses were consistently found amongst the studied constituents. Conclusion: Whilst there was heterogeneity of study models and methods, consistent use of specific models such as SCC25 for in vitro studies and golden hamsters for in vivo studies enabled relative comparability. The constituents of coffee have gained significant interest over the last 30 years, particularly in the last decade, and present an area of interest with significant public health implications. Currently, there is a paucity of literature on utilization of active coffee constituents for the therapeutic treatment of oral cancers. [ABSTRACT FROM AUTHOR]