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Aim: To assess the long‐term stability of attachment gain in infrabony defects (IBDs) 10 years after regenerative treatment with an enamel matrix derivative (EMD) alone. Materials and Methods: Two centres (Frankfurt [F] and Heidelberg [HD]) invited patients for re‐examination 120 ± 12 months after regenerative therapy. Re‐examination included clinical examination (periodontal probing depths (PPD), vertical clinical attachment level (CAL), plaque index (PlI), gingival index (GI), plaque control record, gingival bleeding index and periodontal risk assessment) and review of patient charts (number of supportive periodontal care [SPC] visits). Results: Both centres included 52 patients (29 female; median baseline age: 52.0 years; lower/upper quartile: 45.0/58.8 years; eight smokers), each contributing one IBD. Nine teeth were lost. For the remaining 43 teeth, regenerative therapy showed significant CAL gain after 1 year (3.0; 2.0/4.4 mm; p <.001) and 10 years (3.0; 1.5/4.1 mm; p <.001) during which CAL remained stable (−0.5; −1.0/1.0 mm; p = 1.000) after an average SPC of 9 years. Mixed‐model regression analyses revealed a positive association of CAL gain from 1 to 10 years with CAL 12 months post operation (logistic: p =.01) as well as a higher probability for CAL loss with an increasing vertical extent of a three‐walled defect component (linear: p =.008). Cox proportional hazard analysis showed a positive association between PlI after 12 months and tooth loss (p =.046). Conclusion: Regenerative therapy of IBDs showed stable results over 9 years. CAL gain is associated with CAL after 12 months and decreasing initial defect depth in a three‐walled defect morphology. Tooth loss is associated with PlI 12 months post operation. Clinical trial number: DRKS00021148 (URL: https://drks.de). [ABSTRACT FROM AUTHOR]