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A non‐collocated output tracking problem for a flexible string with tip payload at one end was studied in this paper, which is expected to describe by a wave equation coupled ordinary differential equation (ODE) system. The regulated output and the reference trajectory signal with unknown frequency and amplitude are non‐collocated with the boundary control input. An adaptive approach has been developed to determine the unknown frequency of a disturbance by constituting an auxiliary trajectory and an internal model structure. In order to regulate exponential output tracking, the proposed error‐based adaptive dynamic compensation controller is employed. Closed‐loop stability and well‐posedness is established by exploiting the principle of semigroup theory. Finally, simulation experiments are performed to show the proposed scheme is very effective. [ABSTRACT FROM AUTHOR]

Iodine, an essential trace element for the human body, plays a pivotal role in sustaining health. Malnutrition has emerged as a pressing public health concern, posing a significant threat to human well‐being. Iodine deficiency poses a substantial threat to the development of children, potentially leading to neurological developmental disorders and mental retardation. Conversely, excessive iodine intake can result in structural and functional abnormalities in the thyroid gland. In this study, we selected children aged 3–6 years through a stratified cluster sampling approach in six regions across China to explore the correlation between iodine nutrition and their physical growth. A total of 5920 preschool children participated in this study, with a median urinary iodine concentration (UIC) of 177.33 [107.06, 269.92] μg/L. Among these children, 250 (4.2%) exhibited stunting, 180 (3.0%) were underweight, 198 (3.3%) experienced wasting, 787 (3.3%) were overweight and 414 (7.0%) were classified as obese. The multivariate linear regression revealed that UIC exhibited a positive correlation with body mass index z‐Score (BMIZ) in overweight children (β = 0.038; 95% CI: 0.001, 0.075). In normally growing children, the associations between UIC and height‐for‐age z‐score, weight‐for‐age z‐score and BMIZ displayed nonlinear patterns. Our findings suggest that iodine nutrition is adequate for Chinese children aged 3–6 years. Furthermore, iodine nutrition is intricately linked to the growth and development of these children. Consequently, it is imperative to implement decisive measures to prevent both iodine deficiency and excess. [ABSTRACT FROM AUTHOR]

Summary Space information network (SIN) is difficult to fully utilize the limited on‐board resource due to its dynamic and heterogeneous nature, while the traditional resource management methods cannot adapt to the increasingly diverse task requirements. Space cloud network architecture is an effective technology to reduce the pressure on satellite resources. To effectively manage the space cloud network resources, we design a resources allocation strategy based on resource clustering. Firstly, we propose the space cloud network architecture. Then, we propose a genetic algorithm to cluster the space cloud resources. Finally, we propose a dynamic resource allocation method based on reinforcement learning for the dynamic characteristics of space cloud resources. The method improves the reinforcement learning algorithm through dynamic objective optimization to complete the optimization of multiple objectives in the process of space cloud resources allocation. The simulation results show that the algorithm proposed in this paper reduces the task execution delay by an average of 10.5% compared with the original DQN algorithm and increases the execution success rate by 2.17%. [ABSTRACT FROM AUTHOR]

Hydrosilylation of unsaturated C‐C bonds with hydrosilanes is very important process to access functional organosillicon compounds. Ligands with phosphorus atoms act as a major role in the hydrosilylation of alkenes. A series of organosilicon‐containing phosphinyl ligands were prepared, and the application as ligands for iron catalyzed hydrosilylation of alkenes had been investigated. These catalytic systems show excellent catalytic performance for hydrosilylation of alkenes without other activator. FeCl2/L1 catalyst system showed the best catalytic performance (97.6% conversion of 1‐octene with 99.1% selectivity of the β‐adduct) for the hydrosilylation of olefins, and the hydrosilylation products can be obtained with higher yield for different straight chain olefin. [ABSTRACT FROM AUTHOR]

In order to solve the safety and efficiency problems in the picking process of Waxberry, the slow speed and low precision of high‐density Waxberry target detection under a complex background were studied. A lightweight Waxberry target detection algorithm based on YOLOv5 is studied. In this study, C3‐Faster1 and C3‐Faster2 modules are proposed, which are located in the backbone and neck of the network: C3‐Faster1 can improve the model speed with a simple structure; C3‐Faster2 integrates the context attention mechanism and transform module based on C3‐Faster1 to make the network pay attention to the information of Waxberry image context and expand the channel receptive field. A new pyramid module, SPPFCSPC, is proposed to expand the sensing field and improve the accuracy of boundary detection. It also combines the Coordinate Attention (CA) and Dyhead dynamic detection head to suppress useless information and enhance the detection ability of small targets. Compared to YOLOv4, YOLOv7, and YOLOv8, mean accuracy percentage (mAP) improved by 5.7%, 9.4%, 8.3%. Compared to the base YOLOv5 model, mAP has improved from 86.5% to 91.9%, running on 2 GB Jeston nano, and the improved model is 5.03 frames per second (FPS) faster than YOLOv5. Experiments show that the designed module is more effective in Waxberry detection tasks. [ABSTRACT FROM AUTHOR]

The intermittent and uncertainty of new energy in the grid connection process affects the overall quality of the grid. To resolve the scattered geographical locations, small individual capacities and poor controllability of distributed energy storage (DES) devices, edge computing is applied in conjunction with aggregate service providers to build an edge computing‐based aggregate model of DES. Regarding its characteristics, the schedulable potential of the energy storage device is analysed through modelling. A multi‐objective scheduling model with multiple parties participating in the subject's behaviour is established using the Internet of Things (IoT) optimization strategy. The simulation example of concrete data further verifies the validity of the model. Results demonstrate that the edge computing‐based aggregate model of DES effectively reduces the calculation load's peak‐valley load and reduces the wind power abandonment. In the meantime, the multiple starts and stops of the thermal power unit reduce the operation cost of the unit. The multi‐objective dispatch model can reduce the opportunity cost and payment of DES effectively. This model achieves load peak reduction and valley filling and reduces the peak dispatch cost of the power grid. The research results can provide some ideas for storing and utilizing the new energy. [ABSTRACT FROM AUTHOR]

This article revisits saturated stabilization of the feed‐forward systems that are subject to lower‐order perturbations, with the purpose of providing new analysis approaches. To carry out the saturation reduction analysis, we do not use the existing time‐interval based contradiction approach, but propose a Lyapunov function method; to deal with the reduced system (the closed‐loop system that does not contain saturation any longer), we do not use the "adding a power integrator" backstepping scheme, but propose an approach which is established by jointly using the vector Lyapunov function theory, a matrix measure stability theory and the switching systems theory. As a result, a quite number of inequality computations can be avoided, and the stability conditions summarized in two analysis procedures can be expressed by directly using the system parameters. This article also shows that the established approaches are applicable to the uncertain feedforward systems subject to linear input perturbation and consequently, allows to present new stabilizing control laws for several intractable under‐actuated systems. [ABSTRACT FROM AUTHOR]

Bacteria have distinctive properties that make them ideal for biomedical applications. They can self‐propel, sense their surroundings, and be externally detected. Using bacteria as medical therapeutic agents or delivery platforms opens new possibilities for advanced diagnosis and therapies. Nano‐drug delivery platforms have numerous advantages over traditional ones, such as high loading capacity, controlled drug release, and adaptable functionalities. Combining bacteria and nanotechnologies to create therapeutic agents or delivery platforms has gained increasing attention in recent years and shows promise for improved diagnosis and treatment of diseases. In this review, design principles of integrating nanoparticles with bacteria, bacteria‐derived nano‐sized vesicles, and their applications and future in advanced diagnosis and therapeutics are summarized. [ABSTRACT FROM AUTHOR]

A negatively curved aza‐nanographene (NG) containing two octagons was synthesized by a regioselective and stepwise cyclodehydrogenation procedure, in which a double aza[7]helicene was simultaneously formed as an intermediate. Their saddle‐shaped structures with negative curvature were unambiguously confirmed by X‐ray crystallography, thereby enabling the exploration of the structure–property relationship by photophysical, electrochemical and conformational studies. Moreover, the assembly of the octagon‐embedded aza‐NG with fullerenes was probed by fluorescence spectral titration, with record‐high binding constants (Ka=9.5×103 M−1 with C60, Ka=3.7×104 M−1 with C70) found among reported negatively curved polycyclic aromatic compounds. The tight association of aza‐NG with C60 was further elucidated by X‐ray diffraction analysis of their co‐crystal, which showed the formation of a 1 : 1 complex with substantial concave‐convex interactions. [ABSTRACT FROM AUTHOR]

Non‐conjugated luminescent polymers have received much attention due to their excellent flexibility, processability, and biocompatibility. However, the single emission color and low solid‐state luminescence efficiency restrict their further development. Herein, by introducing carboxyl‐terminated alkyl chains on the rigid and helical polymaleimide backbone, a series of non‐conjugated luminescent polymers are designed and synthesized. Due to the “spring lock” formed by the synergism of scalable helical main chains and flexible alkyl side chains, these polymers exhibit effective cluster luminescence with thermally activated delayed fluorescence (TADF) property, thereby significantly improving the solid‐state luminescence efficiency with the quantum yield up to 59.6%. The TADF emission wavelengths of the polymer powders can be tuned from 498 to 639 nm through changing reaction solvents, because the conformation of helical chains forming clusters is sensitive to solvent polarity. Interestingly, metal ions can induce the polymers to construct self‐repairing cluster luminescence gels, which show excellent potential applications in ammonia detection and information encryption. This work not only provides an effective design strategy for the colorful cluster luminescence with high‐efficiency TADF, but also further reveals the cluster luminescence mechanism and enlightens the promising applications of cluster luminescent gels. [ABSTRACT FROM AUTHOR]

A negatively curved aza‐nanographene (NG) containing two octagons was synthesized by a regioselective and stepwise cyclodehydrogenation procedure, in which a double aza[7]helicene was simultaneously formed as an intermediate. Their saddle‐shaped structures with negative curvature were unambiguously confirmed by X‐ray crystallography, thereby enabling the exploration of the structure–property relationship by photophysical, electrochemical and conformational studies. Moreover, the assembly of the octagon‐embedded aza‐NG with fullerenes was probed by fluorescence spectral titration, with record‐high binding constants (Ka=9.5×103 M−1 with C60, Ka=3.7×104 M−1 with C70) found among reported negatively curved polycyclic aromatic compounds. The tight association of aza‐NG with C60 was further elucidated by X‐ray diffraction analysis of their co‐crystal, which showed the formation of a 1 : 1 complex with substantial concave‐convex interactions. [ABSTRACT FROM AUTHOR]

The present article focuses on the output regulation problem for uncertain 1‐d reaction‐diffusion equation(RDE), in which the disturbance inputs are located at both the interior of the equation and uncontrolled end. Both the reference signal and the disturbances signal are specified due to an exosystem of time‐varying coefficients. The difficulty of the problem is that the control end is noncollocated with the regulated output. The so‐called feedforward control is designed by introducing an regulator, which is determined by infinite‐dimensional equation. A state observer is proposed based on the measurement output to recover the original and the external systems. The suitable feedback control has to be integrated by replacing the states in the expression of feedforward control law. As a result, exponential convergence of the error between the reference signal and the output, and the closed‐loop stability are established. Numerical results are performed the effectiveness of the results. [ABSTRACT FROM AUTHOR]

Tautomers coexisting in an equilibrium system have significant potential for regulating luminescent properties because of their structural differences. However, separating and stabilizing tautomers at room temperature is a considerable challenge. In this study, it is found that hydrogen‐bonded organic frameworks (HOFs) composed of Br‐ anions can effectively separate and stabilize two proton‐transfer tautomers of triarylformamidinium bromide: namely, the nitrogen cation (BA‐N) and carbon cation (BA‐C). The BA‐N crystal consisting of a dense anionic HOF and parallelly aligned organic cations exhibits green thermally activated delayed fluorescence and red room‐temperature phosphorescence (RTP). The BA‐C crystal contains acetone molecules that induce an antiparallel arrangement of the organic cations to form a loose HOF, producing blue prompt fluorescence and green RTP. Interestingly, switching of the HOFs between BA‐N and BA‐C can be achieved through the uptake and release of acetone, thereby dynamically adjusting multiple luminescent properties. Consequently, the HOF crystals can be used for the highly sensitive and specific sensing of acetone with a detection limit of 66.74 ppm. This study not only stabilizes tautomeric luminescent materials at room temperature, but also provides a new method for constructing smart HOFs with a sensitive response to a stimulus. [ABSTRACT FROM AUTHOR]

Tautomers coexisting in an equilibrium system have significant potential for regulating luminescent properties because of their structural differences. However, separating and stabilizing tautomers at room temperature is a considerable challenge. In this study, it is found that hydrogen‐bonded organic frameworks (HOFs) composed of Br‐ anions can effectively separate and stabilize two proton‐transfer tautomers of triarylformamidinium bromide: namely, the nitrogen cation (BA‐N) and carbon cation (BA‐C). The BA‐N crystal consisting of a dense anionic HOF and parallelly aligned organic cations exhibits green thermally activated delayed fluorescence and red room‐temperature phosphorescence (RTP). The BA‐C crystal contains acetone molecules that induce an antiparallel arrangement of the organic cations to form a loose HOF, producing blue prompt fluorescence and green RTP. Interestingly, switching of the HOFs between BA‐N and BA‐C can be achieved through the uptake and release of acetone, thereby dynamically adjusting multiple luminescent properties. Consequently, the HOF crystals can be used for the highly sensitive and specific sensing of acetone with a detection limit of 66.74 ppm. This study not only stabilizes tautomeric luminescent materials at room temperature, but also provides a new method for constructing smart HOFs with a sensitive response to a stimulus. [ABSTRACT FROM AUTHOR]

Studies have shown that saikosaponin D (SSD) has favorable neurotherapeutic effects. Therefore, the objective of this study was to explore the efficacy and possible molecular mechanisms of SSD on pilocarpine (PP)‐induced astrocyte injury. Primary astrocytes were isolated from juvenile rats and identified using immunofluorescence. The cells were treated with PP and/or SSD for 6 h and 12 h, respectively, followed by measurement of their viability through 3‐(4,5‐dimethylthiazol)‐2,5‐diphenyl‐tetrazolium bromide (MTT) assay. Next, quantitative real‐time polymerase chain reaction (qRT‐PCR) was used to measure the expression levels of Glial fibrillary acidic protein (GFAP), C3, S100 calcium binding protein A10 (S100a10), pentraxin 3 (Ptx3), toll‐like receptor 4 (TLR4), and RAG in astrocytes after different treatments. Enzyme‐linked immunosorbent assay and biochemical tests were utilized to evaluate the level of inflammatory factors [interleukin (IL)‐1β, IL‐6, and tumor necrosis factor alpha (TNF‐α)] secreted by cells and the content of oxidative stress‐related factors (malondialdehyde [MDA] and glutathione [GSH]) or enzyme activity (catalase [CAT] and glutathione peroxidase [GPX]) in cells. The JC‐1 mitochondrial membrane potential (MMP) fluorescence probe was used to measure the MMP in astrocytes. Additionally, western blot was applied to test the expression of proteins related to the nod‐like receptor protein 3 (NLRP3)/caspase‐1 signaling pathway. PP treatment (1 mM) induced cell injury by significantly reducing the viability of astrocytes and expression of cellular markers. SSD treatment (4 μM) had no toxicity to astrocytes. Besides, SSD (4 μM) treatment could significantly up‐regulate the cell viability and marker expression of PP‐induced astrocytes. Furthermore, SSD could be employed to inhibit inflammation (reduce IL‐1β, IL‐6, and TNF‐α levels) and oxidative stress (decrease MDA level, elevate GSH level, the activity of CAT and GPX), and ameliorate mitochondrial dysfunction (upregulate JC‐1 ratio) in PP‐induced astrocytes. Moreover, further mechanism exploration revealed that SSD treatment significantly reduced the activity of the NLRP3/caspase‐1 signaling pathway activated by PP induction. SSD increased cell viability, inhibited inflammation and oxidative stress response, and ameliorated mitochondrial dysfunction in PP‐induced astrocyte injury model, thus playing a neuroprotective role. The mechanism of SSD may be related to the inhibition of the NLRP3/caspase‐1 inflammasome. [ABSTRACT FROM AUTHOR]

Nanofluidic membranes are currently being explored as potential candidates for osmotic energy harvesting. However, the development of high‐performance nanofluidic membranes remains a challenge. In this study, the ultrathin MXene membrane (H‐MXM) is prepared by ultrathin slicing and realize the ion horizontal transportation. The H‐MXM membrane, with a thickness of only 3 µm and straight subnanometer channels, exhibits ultrafast ion transport capabilities resembling an “ion freeway”. By mixing artificial seawater and river water, a power output of 93.6 W m−2 is obtained. Just as cell membranes have an ultrathin thickness that allows for excellent penetration, this straight nanofluidic membrane also possesses an ultrathin structure. This unique feature helps to shorten the ion transport path, leading to an increased ion transport rate and improveS performance in osmotic energy conversion. [ABSTRACT FROM AUTHOR]

In a search for novel nonsugar α‐glucosidase inhibitors for diabetes treatment, a series of N‐(phenylsulfonyl)thiazole‐2‐carboxamide derivatives were designed and synthesized, the α‐glucosidase inhibitory activities were then evaluated. Several compounds with promising α‐glucosidase inhibitory effects were identified. Among these, compound W24 which shows low cytotoxicity and good α‐glucosidase inhibitory activity with an IC50 value of 53.0 ± 7.7 μM, is more competitive compared with the commercially available drug acarbose (IC50 = 228.3 ± 9.2 μM). W24 was identified as a promising candidate in the development of α‐glucosidase inhibitors. Molecular docking studies and molecular dynamics simulation were also performed to reveal the binding pattern of the active compound to α‐glucosidase, and the binding free energy of the best compound W24 was 36.3403 ± 3.91 kcal/mol. [ABSTRACT FROM AUTHOR]

The Lamasu deposit is the first large copper (Cu) deposit with ~0.6 Mt Cu reserve in the Chinese Western Tianshan Orogen (NW China). The Cu orebodies are mainly hosted in the exoskarn of the Proterozoic Kusongmuqieke Group. Now, the metallogenic mechanism of newly discovered skarn Cu orebodies (0.5 Mt Cu) remains poorly constrained. In this study, we conducted LA‐ICP‐MS U–Pb isotope dating, EPMA and LA‐ICP‐MS geochemical analyses on different generations of garnet from Lamasu to elucidate the magmatic hydrothermal evolution and its timing. Garnets from the Lamasu exoskarn can be divided into three types: reddish‐brown coarse‐grained Grt‐I, light brown fine‐grained Grt‐II and yellowish‐green heterogranular Grt‐III, with U–Pb age of 389.1 ± 2.0 Ma, 387.1 ± 1.8 Ma and 387.0 ± 2.3 Ma, respectively. These dates represent the oldest Cu mineralization age in the Chinese Western Tianshan, coeval with the Middle Devonian subduction of the North Tianshan oceanic plate. Grt‐I to Grt‐III particles are mainly andradite with minor grossularite, and they have different REE compositions. The Grt‐I has total REE contents (∑REE) of 101.47 to 262.87 ppm, with steeply right‐inclining REE distribution patterns (LREE/HREE of 3.81 to 68.50) and positive Eu anomaly. The Grt‐II core has ∑REE of 163.49–249.52 ppm, LREE/HREE of 2.00–4.71, and negative Eu anomaly. The Grt‐II rim has ∑REE of 46.34–99.99 ppm, with LREE/HREE of 18.06–177.23, and positive Eu anomaly. The ∑REE of Grt‐III range from 31.71 to 219.02 ppm, with flat REE distribution pattern and positive Eu anomaly, and the LREE/HREE ranges from 2.16 to 9.07. These garnets have similar trace element compositions, featured by LILE‐depletions (e.g., Rb, Ba and Sr) and HFSE enrichments (e.g., Th, U, Nb and Ce). Micro‐texture and geochemical composition of garnets indicate that the Lamasu magmatic hydrothermal system could have changed from an open to a closed environment, and from infiltration metasomatism to diffusive metasomatism, which formed Grt‐I, Grt‐II and Grt‐III successively. These garnets generally formed in a relatively oxidized fluid environment, which inhibited early sulphide precipitation and favoured for Cu enrichment during the ore fluid evolution. [ABSTRACT FROM AUTHOR]

Adverse childhood experiences (ACEs) have been associated with poor HIV testing in adulthood yet, they have not been extensively described in those at increased risk for HIV. Cross‐sectional analysis data (n = 204,231) on ACEs and HIV testing were obtained from the 2019–2020 Behavioural Risk Factor Surveillance Survey. Weighted logistic regression models were used to access the association of ACEs exposure, ACEs score, and ACEs type with HIV testing among adults with HIV risk behaviours, and stratified analysis was also performed to examine gender differences. The results indicated the overall rate of HIV testing was 38.8% and was higher among those with HIV risk behaviours (64.6%) than those without (37.2%). In populations with HIV risk behaviours, the negative association of HIV testing with ACEs exposure, ACEs score, and ACEs type was identified. Relative to those without ACEs, adults who were exposed to ACEs might decrease the rate of HIV testing, participants with ≥4 ACEs scores were less likely to have HIV testing, and childhood exposure to sexual abuse had the greatest impact on HIV testing. For both males and females, childhood exposure to ACEs was associated with lower odds of HIV testing and ACEs score ≥4 had the most robust associations with HIV testing. For males, those who experienced witnessed domestic violence had the lowest odds of HIV testing but the odds of engaging in HIV testing for females were the lowest among those who experienced childhood sexual abuse. [ABSTRACT FROM AUTHOR]

With increasing coverage, density, and accuracy of the global inland water altimetry record, remote sensing observations of water surface elevation (WSE) and water surface slope (WSS) are becoming available for the world's rivers. In steady, uniform flows, WSS is invariable, while there is a unique one‐to‐one relationship between WSE and discharge, the rating curve. While the assumptions of steady uniform flow are appropriate for many rivers, they are violated upstream of river confluences. We present a simple analytical hydraulic model of river confluences using the theory of steady, gradually varied flow. We apply the model to four river confluences in the Mississippi‐Missouri river system. We determine the spatial extent of the backwater‐affected zones and map WSE‐discharge and WSS‐discharge relationships. We show that coincident measurements of WSE and WSS from new satellite altimetry missions effectively constrain discharge estimates from space in the backwater‐affected zones upstream of river confluences. Plain Language Summary: New satellite altimetry missions monitor water levels in global rivers at unprecedented spatio‐temporal resolution and accuracy. One principal objective of this monitoring effort is to map river flow in space and time, understand the impacts of climatic change on river flows, and provide river flow estimates for practical water resources applications. In many locations and situations, there is a one‐to‐one relationship between river flow and river water level. This so‐called rating curve can be used to directly translate water level observations into river flow estimates. However, the concept of the rating curve breaks down whenever the flow in the river is significantly different from steady uniform flow, which is the flow occurring in a long and uniform river reach with constant boundary inflow. Upstream of river confluences, conditions are often non‐uniform, because high flow in one tributary can coincide with low flow in the other, leading to significant backwater effects in both tributaries. This study models water level and water surface slope dynamics upstream of river junctions and highlights the value that data sets from new satellite missions provide for understanding the hydraulics around river confluences and for estimating flow upstream of river confluences from space. Key Points: The classic stage‐discharge rating curve concept fails upstream of river confluences because of backwater effectsHydraulic modeling confirms that unique stage‐slope‐discharge relationships exist upstream of river confluencesNew satellite altimetry observations of river stage and slope reveal stage‐slope‐discharge relationships for selected river confluences [ABSTRACT FROM AUTHOR]

Summary: Conventional fault recognition algorithms can only recognize the classes of faults that have appeared in wind turbine systems. However, if a new category of faults appears, the traditional algorithm can only misclassify it into the class of pre‐existing faults. In this paper, a new class fault recognition method based on deep learning is proposed. Firstly, the initialized model is built using known fault data, including detectors and classifiers. Secondly, the new class fault data detected by the detectors are put into the cache, and when the cache overflows, the new class faults are augmented with data using generative adversarial networks. Finally, the new class fault data and the generated data are added to the initial training set, and the structure and weights of the initialized model are updated using the new training set. In this way, the purpose of recognizing the new class of faults is achieved. The experimental results show that the proposed detection algorithm can effectively detect new class faults and the model can efficiently solve the problem of the new class of fault recognition after data augmentation. [ABSTRACT FROM AUTHOR]

Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects multiple organs and systems, including joints, the cardiovascular system, lungs, skin, kidneys, the nervous system, and blood. The clinical presentations of SLE are diverse and vary widely. In this report, we present a case of a patient whose SLE was complicated by hemochromatosis to enhance clinicians' comprehension of this infrequent or rare complication of SLE. We aim to provide insights into the diagnosis and treatment processes of this condition. [ABSTRACT FROM AUTHOR]

Although previous neuroimaging evidence has confirmed the brain functional disturbances in thyroid‐associated ophthalmopathy (TAO), the dynamic characteristics of brain activity and functional connectivity (FC) in TAO were rarely concerned. The present study aims to investigate the alterations of temporal variability of brain activity and FC in TAO using resting‐state functional magnetic resonance imaging (rs‐fMRI). Forty‐seven TAO patients and 30 age‐, gender‐, education‐, and handedness‐matched healthy controls (HCs) were enrolled and underwent rs‐fMRI scanning. The dynamic amplitude of low‐frequency fluctuation (dALFF) was first calculated using a sliding window approach to characterize the temporal variability of brain activity. Based on the dALFF results, seed‐based dynamic functional connectivity (dFC) analysis was performed to identify the temporal variability of efficient communication between brain regions in TAO. Additionally, correlations between dALFF and dFC and the clinical indicators were analyzed. Compared with HCs, TAO patients displayed decreased dALFF in the left superior occipital gyrus (SOG) and cuneus (CUN), while showing increased dALFF in the left triangular part of inferior frontal gyrus (IFGtriang), insula (INS), orbital part of inferior frontal gyrus (ORBinf), superior temporal gyrus (STG) and temporal pole of superior temporal gyrus (TPOsup). Furthermore, TAO patients exhibited decreased dFC between the left STG and the right middle occipital gyrus (MOG), as well as decreased dFC between the left TPOsup and the right calcarine fissure and surrounding cortex (CAL) and MOG. Correlation analyses showed that the altered dALFF in the left SOG/CUN was positively related to visual acuity (r =.409, p =.004), as well as the score of QoL for visual functioning (r =.375, p =.009). TAO patients developed abnormal temporal variability of brain activity in areas related to vision, emotion, and cognition, as well as reduced temporal variability of FC associated with vision deficits. These findings provided additional insights into the neurobiological mechanisms of TAO. [ABSTRACT FROM AUTHOR]

Objective: Although pilon fractures are rare in clinical practice, they are difficult to treat because of their complexity. Effective fixation of the fracture fragment is the key to the treatment of pilon fractures. Plate osteosynthesis is common clinically, but there are many types of plates and the evaluation of the effect of fixation plates is not comprehensive. This study attempted to compare the capture effect of different fixation plates on the fracture fragments based on 3D modeling and fine distinctions of fracture fragments. Methods: The computed tomography (CT) images before treatment of 127 patients with pilon fractures from January 2019 to December 2021 were retrospectively collected. The fracture lines were mapped and digitally displayed as 3D images using MIMICS 21 software. APLUS distal tibia anatomical locking plate (Plate A) and ZIMMER distal tibia anatomical plate (Plate B) were placed on a pseudo‐bone model and CT scans were used to determine the number of screws in the major and minor fragments of pilon fractures. The frequency of the two plates capturing the fracture fragments was recorded. Results: Under Assumption 1 or 2, Plate A performed significantly better than Plate B in capturing the major, Chaput, Volkmann, medial malleolus, and die‐punch fracture fragments. Plate A captured markedly more minor fragments than Plate B under Assumption 2 but was not significantly different from Plate B under Assumption 1. Plate A or Plate B showed no obvious difference between major and minor capture rates under the same assumption, and A1 or B1 showed a markedly higher capture rate compared with A2 or B2. In addition, there was a significant positive correlation between the major capture rate and the major fragments in B1, and a significant negative correlation between the minor capture rate and the minor fragments in Plates A and B. However, there was no correlation between the major capture rate of Plate A and the major fragments. Conclusion: The APLUS distal tibial anatomical locking plate is superior to the ZIMMER distal tibia anatomical plate in the ability to capture distal tibial fragments in pilon fracture cases. [ABSTRACT FROM AUTHOR]

Background: The study aims to explore the incidence and risk factors of cognitive dysfunction in hemodialysis patients. Methods: PubMed, Embase, Cochrane Library, and Web of Science databases were searched for clinical studies on the association between hemodialysis and cognitive dysfunction from the database's inception to 1 December 2022. Two researchers independently completed data extraction and risk of bias assessments for the included studies. All statistical analyses were performed using STATA15.0 software. Results: Ten studies were included in this meta‐analysis, with a total of 5535 hemodialysis patients, that is, 2033 patients with cognitive dysfunction and 3502 patients with normal cognitive function. The Newcastle–Ottawa Scale scores of the included studies were greater than 5. Meta‐analysis results suggested that the incidence of cognitive dysfunction in hemodialysis patients was (effect size = 51%, 95% confidence interval [CI] [0.33, 0.69]), and hemodialysis patients with cognitive dysfunction were often older than those with normal cognition (standard mean difference [SMD] = 0.49, 95% CI [0.31, 0.68]). Female gender was a risk factor for cognitive dysfunction in hemodialysis patients (relative risk [RR] = 1.21, 95% CI [1.04, 1.41]); diabetes (RR = 1.33, 95% CI [1.04, 1.71]) and stroke (RR = 1.66, 95% CI [1.08, 2.55]) increased the incidence of cognitive dysfunction in hemodialysis patients. Conclusions: The most important risk factors for cognitive dysfunction associated with hemodialysis might be female gender, old age, diabetes, and stroke. Close attention should be paid to such patients for early prevention. [ABSTRACT FROM AUTHOR]

Introduction: To investigate the optimal range of quantitative ablation index (AI) value during superior vena cava (SVC) electrical isolation by radiofrequency catheter ablation (RFCA). Methods: First, in a development cohort of patients with atrial fibrillation (AF), the RFCA with 40 W was performed to complete SVC isolation guided by the conduction breakthrough point from the right atrium to SVC. Then, the range of AI value was calculated by offline analysis on different segments of SVC. Lastly, for the validation of AF patients, the safety and effectiveness of SVC isolation with the optimized target range of AI value were evaluated with an additional adenosine test. Results: A total of 101 patients with AF were included in the study (44 patients in the development cohort/57 in the validation cohort). The segmental ablation strategy was applied in 70% of the patients. According to the offline analysis of the AI values in the development cohort, the target AI value range was set as 350–400. The success rate of SVC isolation in the validation cohort was significantly higher than that in the exploration cohort (100% vs. 90.9%, p =.02), and no complications occurred in the exploration cohort. During the adenosine test, the recovery rate of electrical conduction in SVC was significantly lower than that in the pulmonary vein (3.5% vs. 17.5%). Conclusion: The target AI value with a range from 350 to 400 is safe and effective for high‐power RFCA to complete SVC isolation. [ABSTRACT FROM AUTHOR]

Summary: In this paper a semi‐parametric approach is developed to model non‐linear relationships in time series data using polynomial splines. Polynomial splines require very little assumption about the functional form of the underlying relationship, so they are very flexible and can be used to model highly non‐linear relationships. Polynomial splines are also computationally very efficient. The serial correlation in the data is accounted for by modelling the noise as an autoregressive integrated moving average (ARIMA) process, by doing so, the efficiency in nonparametric estimation is improved and correct inferences can be obtained. The explicit structure of the ARIMA model allows the correlation information to be used to improve forecasting performance. An algorithm is developed to automatically select and estimate the polynomial spline model and the ARIMA model through backfitting. This method is applied on a real‐life data set to forecast hourly electricity usage. The non‐linear effect of temperature on hourly electricity usage is allowed to be different at different hours of the day and days of the week. The forecasting performance of the developed method is evaluated in post‐sample forecasting and compared with several well‐accepted models. The results show the performance of the proposed model is comparable with a long short‐term memory deep learning model. [ABSTRACT FROM AUTHOR]

The cloud computing center can dynamically respond to various needs, schedule computing resources, and provide users with convenient IT services. As the demand for cloud computing services continues to increase, the scale of the data center is getting larger and larger, and the problem of high energy consumption of equipment is becoming more and more prominent. Therefore, building a green data center is key to ensuring the development of the technology industry. Virtual machine online migration technology has been widely used in energy consumption management, which plays an important role in the energy‐saving management of large‐scale data centers. Considering the problem of energy consumption in a multi‐data center environment, a cross‐data center virtual machine migration strategy is proposed, EVMA. First, the target data center of the virtual machine migration is determined according to the bandwidth between data centers, and then the overload host and virtual machine selection strategy is determined according to the historical CPU load. The experimental results showed that the algorithm had a good performance in reducing the energy consumption of the data center and ensuring the quality of service. [ABSTRACT FROM AUTHOR]

Electroosmotic pumps can deliver liquid without moving parts, making them suitable for microfluidic and lab‐on‐chip systems. Previously, alternating current electroosmotic pumps were constructed using pairs of coplanar asymmetrical interdigitated microelectrodes on the same substrate. In this work, a simpler micropumping system is developed, separating the electrodes on two substrates and breaking the symmetry by half‐depositing electrodes with 3D microstructures. Numerical simulation models of the pumping system and experimental velocity profiles are used to explain the fluid motion mechanism and structure‐dependent pumping performance. In addition to its efficiency and simplicity, this new pumping system also allows for the creation of a microvortex device and an active microfluidics device. This scalable micropumping system provides a way to pump liquids at microscopic or macroscopical scale in complex microfluidics systems. [ABSTRACT FROM AUTHOR]

In unsaturated composite liners, the heterogeneous distribution of water content and capillarity are common phenomena with remarkable influence on the transport parameters. This study presents an analytical solution to assess the effect of unsaturation‐dependent retardation and capillarity on the organic contaminant diffusion through an unsaturated composite liner. The solution is obtained by the generalized integral transform technique and is verified against other analytical and numerical solutions. Particular attention is paid to the potential errors in predicting organic contaminant transport caused by unsaturation‐independent retardation factor assumption. The results show that neglecting saturation‐dependent retardation may cause considerable errors. The considerations of capillary fringe and degradation also have significant effects on the errors. In addition, a simplified solution based on a new averaged retardation factor is proposed and its performance is evaluated. [ABSTRACT FROM AUTHOR]

Nonalcoholic steatohepatitis (NASH) has become a major concern that threatens human health worldwide. The underlying pathogenesis was crucial but remained poorly understood. Here, we found that the expression of hepatic farnesyl diphosphate synthase (FDPS) was increased in mice and patients with NASH. Elevated FDPS levels were positively correlated with NASH severity. Overexpression of FDPS in mice provoked increased lipid accumulation, inflammation, and fibrosis, while hepatic FDPS deficiency protected mice from NASH progression. Importantly, pharmacological inhibition of FDPS with clinically used alendronate remarkably attenuated NASH‐associated phenotypes in mice. Mechanistically, we demonstrated that FDPS increased its downstream product farnesyl pyrophosphate levels, which could function as an aryl hydrocarbon receptor (AHR) agonist to upregulate the expression of fatty acid translocase CD36, to accelerate the development of NASH. Collectively, these findings suggest that FDPS exacerbates NASH via AHR‐CD36 axis and identify FDPS as a promising target for NASH therapy. [ABSTRACT FROM AUTHOR]

The short‐circuit withstand capability of the transformer is crucial to the reliability of power systems. Research on the short‐circuit characteristics of windings is the basis for improving the stability of power transformers. Although many studies focus on electromagnetic force and cumulative deformation of two‐winding transformers, there is a lack of careful comparison of the electromagnetic and mechanical characteristics of three‐winding transformers, as well as the cumulative effect of stress, displacement and strain. In this paper, the model is established to study temporal response and spatial distribution of the electromagnetic and mechanical properties under short‐circuit impacts. The results show that the short‐circuit effects on medium and low‐voltage windings are more severe than on high‐voltage windings. The first current peak will lead to the greatest threat. Second, the influences of iron core and pre‐stress on short‐circuit characteristics are investigated. The characteristics of windings differ between inside and outside the iron core window, which is pronounced for high‐voltage winding. Besides, the greater pre‐stress is not better for the stability of windings. Finally, it is found that the residual stress and displacement continue to accumulate and the plastic strain appears under multiple short‐circuit impacts. This work is helpful for the analysis of short‐circuit withstand capability of transformers. © 2023 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC. [ABSTRACT FROM AUTHOR]

Ionic liquids (ILs)‐incorporated solid‐state polymer electrolytes (iono‐SPEs) have high ionic conductivities but show non‐uniform Li+ transport in different phases. This work greatly promotes Li+ transport in polymer phases by employing a poly (vinylidene fluoride‐trifluoroethylene‐chlorotrifluoroethylene) [P(VDF‐TrFE‐CTFE), PTC] as the framework of ILs to prepare iono‐SPEs. Unlike PVDF, PTC with suitable polarity shows weaker adsorption energy on IL cations, reducing their possibility of occupying Li+‐hopping sites. The significantly higher dielectric constant of PTC than PVDF facilitates the dissociation of Li‐anions clusters. These two factors motivate Li+ transport along PTC chains, narrowing the difference in Li+ transport among varied phases. The LiFePO4/PTC iono‐SPE/Li cells cycle steadily with capacity retention of 91.5 % after 1000 cycles at 1 C and 25 °C. This work paves a new way to induce uniform Li+ flux in iono‐SPEs through polarity and dielectric design of polymer matrix. [ABSTRACT FROM AUTHOR]

Ionische Flüssigkeiten (ionic liquids, ILs) eingebettet in feste Polymer‐Elektrolyte (iono‐SPEs) weisen eine hohe ionische Leitfähigkeit auf, zeigen jedoch einen nicht‐uniformen Li+‐Transport in den verschiedenen Phasen. In dieser Arbeit wird gezeigt wie der Li+‐Transport in Polymerphasen erheblich durch ein Poly(vinylidenfluorid‐trifluorethylen‐chlorotrifluorethylen)‐Netzwerk [P(VDF‐TrFE‐CTFE), PTC] ILs zur Herstellung von iono‐SPEs verbessert werden kann. Im Gegensatz zu PVDF zeigt PTC mit geeigneter Polarität eine schwächere Adsorptionsenergie an IL‐Kationen, wodurch ihre Möglichkeit, Li+‐Sprungstellen zu besetzen, reduziert wird. Die deutlich höhere Dielektrizitätskonstante von PTC als PVDF erleichtert die Dissoziation von Li‐Anionen‐Clustern. Diese beiden Faktoren verstärken den Li+‐Transport entlang von PTC‐Ketten, wodurch der Unterschied des Li+‐Transports zwischen den verschiedenen Phasen verringert wird. Die LiFePO4/PTC iono‐SPE/Li‐Zellenzyklen stabil mit einer Kapazitätserhaltung von 91.5 % nach 1000 Zyklen bei 1 C und 25 °C. Diese Arbeit ebnet einen neuen Weg zur Erzeugung eines gleichmäßigen Li+‐Flusses in iono‐SPEs durch Optimierung der Polarität und Dielektrizität der Polymermatrix. [ABSTRACT FROM AUTHOR]

Since the breakthrough of conductive polymers in 1977, scientists have made great efforts to create small band gap (Eg) conjugated polymers. Two general strategies to design small Eg conjugated polymers are quinoid structure and donor‐acceptor structure. Ultrasmall Eg conjugated polymers (Eg<1.0 eV) always suffer from poor air stability because of high‐lying HOMO energy levels. In this work, we report a new strategy to design ultrasmall Eg conjugated polymers by N−B←N unit, i.e. balanced resonant boron‐nitrogen covalent bond (B−N) and boron‐nitrogen coordination bond (B←N). The resulting polymer exhibits an Eg of 0.82 eV and an onset absorption wavelength of >1500 nm. Moreover, the polymer exhibits excellent air stability because of its low‐lying LUMO/HOMO energy levels. An unprecedented property of this polymer is the selective light absorption in the infrared range (800–1500 nm) and high transparency in the visible range (400–780 nm). Using this property, for the first time, we demonstrate the application of conjugated polymers as transparent thermal‐shielding coating layer on glass, which reduces indoor solar irradiation through window and consequently reduces power consumption for cooling of buildings and cars in summer. [ABSTRACT FROM AUTHOR]

Since the breakthrough of conductive polymers in 1977, scientists have made great efforts to create small band gap (Eg) conjugated polymers. Two general strategies to design small Eg conjugated polymers are quinoid structure and donor‐acceptor structure. Ultrasmall Eg conjugated polymers (Eg<1.0 eV) always suffer from poor air stability because of high‐lying HOMO energy levels. In this work, we report a new strategy to design ultrasmall Eg conjugated polymers by N−B←N unit, i.e. balanced resonant boron‐nitrogen covalent bond (B−N) and boron‐nitrogen coordination bond (B←N). The resulting polymer exhibits an Eg of 0.82 eV and an onset absorption wavelength of >1500 nm. Moreover, the polymer exhibits excellent air stability because of its low‐lying LUMO/HOMO energy levels. An unprecedented property of this polymer is the selective light absorption in the infrared range (800–1500 nm) and high transparency in the visible range (400–780 nm). Using this property, for the first time, we demonstrate the application of conjugated polymers as transparent thermal‐shielding coating layer on glass, which reduces indoor solar irradiation through window and consequently reduces power consumption for cooling of buildings and cars in summer. [ABSTRACT FROM AUTHOR]

Objective: Free flaps are widely used for the repair of soft tissue defects in the lower limbs, but there is still a specific rate of necrosis. Few clinical retrospective studies have analyzed the nontechnical risk factors for lower limb free flap necrosis. This study aimed to analyze the nontechnical causes of flap necrosis in lower limb soft tissue reconstruction in order to identify risk factors and improve the survival rate of free flaps. Methods: Clinical data from 244 cases of soft tissue defects of the leg or foot that were repaired with a free flap from January 2011 to June 2020 were retrospectively analyzed. The flap results were divided into complete survival and necrosis groups. The patients' general information, smoking history, soft tissue defect site, Gustilo‐Anderson classification, shock after injury, type and size of the flap, and time from injury to flap coverage were recorded. A logistic regression model was used to analyze the correlations between flap necrosis and possible risk factors. Results: Of the 244 flaps, 32 suffered from partial or total necrosis, and 212 completely survived. Univariate analysis showed that age, smoking history, soft tissue defect site, and time from injury to flap coverage were significantly correlated with flap necrosis (p ≤ 0.2). Multivariate logistic regression analysis showed that moderate‐to‐severe smoking history (p < 0.001, odds ratio [OR] = 10.259, 95% confidence interval [CI] = 2.886–36.468), proximal leg defect (p = 0.006, OR = 7.095, 95% CI = 1.731–29.089), and time from injury to flap coverage >7 days (p = 0.003, OR = 12.351, 95% CI = 2.343–65.099) were statistically significant risk factors for flap necrosis (p < 0.05), and age was excluded (p = 0.666; p = 0.924). Conclusion: The risk of flap necrosis was significantly increased when the soft tissue defect was located in the proximal leg, the time from injury to flap coverage was >7 days, and the patient had a moderate‐to‐severe smoking history. These three risk factors have an increased influence on flap necrosis and have guiding significance in predicting flap prognosis. [ABSTRACT FROM AUTHOR]

Introduction: Thrombotic thrombocytopenia purpura (TTP) associated with systemic lupus erythematous (SLE), features the appearance of inhibitory autoantibodies against ADAMTS13. Rituximab and belimumab (BEL), as both targeting B cells, seem to be an optimal therapy to induce clinical remission, prevent relapse of disease and contribute to glucocorticoid induction. However, the clinical outcome of SLE‐TTP treated with sequential therapy between rituximab and BEL remain elusive. Case Series: We reported the clinical outcomes of 4 patients diagnosed with SLE‐TTP who were administrated a combination of corticosteroids, plasma exchange, and rituximab at stage of induction. BEL was utilized to rapidly reduce the reliance on these agents and prevent relapse of TTP at maintenance stage. Ultimately, 4 patients fully recovered with a SLE Disease Activity Index score of 0 and reached the goal at dose of prednisolone <7.5 mg/d without relapse. Conclusion: Sequential treatment of rituximab and BEL could be an encouraging approach in treatment of SLE‐TTP and rapid glucocorticoid reduction. [ABSTRACT FROM AUTHOR]

Spin‐momentum locking is universal and an inherent property of evanescent electromagnetic (EM) waves, which transfers the spinning or handedness of electromagnetic waves onto their propagation direction. This motivates an approach to investigate the polarization‐controlled directional transmission or emission. Here, the spin‐momentum locking is demonstrated in spoof surface plasmon polariton (SSPP) waveguides, and momentum‐controlled radiation is further realized in SSPP‐patch antennas. The study shows that the circular polarization of the SSPP‐patch antennas originates from the spin‐momentum locking in the SSPP waveguides and hence is determined by the propagation direction of the SSPP modes. Two examples are presented to achieve ±45° dual‐polarizations and vertical/horizontal dual‐polarizations by combining the SSPP‐patch antenna with hybrid couplers. Finally, a straightforward method is proposed for synthesizing the polarization emitted by the SSPP‐patch antenna, allowing access to arbitrary polarization states on the Poincare sphere. The SSPP‐patch antenna is polarization responsive, shedding light on chiral sensors, Stokes polarimetry, and polarization measurement. Hence, the spin‐momentum locking and the related momentum‐controlled radiations provide additional freedom to regulate the EM waves by engineering the helicity in the SSPP waveguide. [ABSTRACT FROM AUTHOR]

Constructing high performance electrocatalysts for lithium polysulfides [LiPSs] adsorption and fast conversion is the effective way to boost practical energy density and cycle life of rechargeable lithium-sulfur [Li-S] batteries, which have been regarded as the most promising next generation high energy density battery but still suffering from LiPSs shuttle effect and slow sulfur redox kinetics. Herein, a single atomic catalyst ofFe-N4 moiety doping periphery with S [Fe-NSC] is theoretically and experimentally demonstrated to enhance LiPSs adsorption and facilitated sulfur conversion, due to more charge density accumulated around Fe-NSC configuration relative to bare Fe-N4 moiety. Thereafter, the graphene oxide supported Fe-NSC catalyst [Fe-NSC@GO] is modified to the commercial separator through a simple slurry casting method. Thus, Li-S cells with Fe-NSC@GO modified separators display high discharge capacity and excellent cyclability, showing 1156 mAh g-1 at 1 C rate and a low capacity decay of only 0.022% per cycle over 1000 cycles. Even with a high sulfur loading of 5.1 mg cm-2, the cell still delivers excellent cycling stability. This work provides a fresh insight into electrocatalyst structural tuning to improve the electrochemical performance of Li-S batteries. [ABSTRACT FROM AUTHOR]

Cystatin M/E (encoded by the CST6 gene) is a cysteine protease inhibitor, that exerts regulatory and protective effects against uncontrolled proteolysis mainly by directly regulating cathepsin V, cathepsin L, and legumain activities. Previous studies have suggested that CST6 may exert a regulatory role in epidermal differentiation and hair follicle formation by inhibiting the activity of respective cognate target proteases. However, until recently, studies have revealed that loss‐ or gain‐of‐function of the CST6 gene causes dry skin with hypotrichosis in humans. Here, we reported two siblings of Chinese origin with dry skin, desquamation and abnormal keratosis without hypotrichosis. By applying whole‐exome sequencing, we identified homozygous loss‐of‐function mutation c.251G > A (p.Gly84Asp) in the CST6 gene as the underlying genetic cause. Further fluorimetric enzyme assays demonstrated the mutant cystatin M/E protein lost its inhibitory function on the protease activity of cathepsins. Moreover, the corresponding mutation in mice resulted in excessive cornification, desquamation, impaired skin barrier function, and abnormal proliferation and differentiation of keratinocytes. In conclusion, the homozygous missense mutation c.251G > A in CST6 gene resulted in dry skin, desquamation, as well as abnormal keratosis of the skin, promoting our understanding of the role of protease‐antiprotease balance in human skin disorders. [ABSTRACT FROM AUTHOR]

As a green route for large‐scale energy storage, aqueous organic redox flow batteries (AORFBs) are attracting extensive attention. However, most of the reported AORFBs were operated in an inert atmosphere. Herein, we clarify this issue by using the reported AORFB (i.e. 3, 3′‐(9,10‐anthraquinone‐diyl)bis(3‐methylbutanoicacid) (DPivOHAQ)||Ferrocyanide) as an example. We demonstrate that the dissolved O2 can oxidize the discharged DPivOHAQ in anolyte, leading to capacity‐imbalance between anolyte and catholyte. Therefore, this cell shows continuous capacity fading when operated in an air atmosphere. We propose a simple strategy for this challenge, in which the oxygen evolution reaction (OER) in catholyte is employed to balance oxygen reduction reaction (ORR) in anolyte. When using the Ni(OH)2‐modifed carbon felt (CF) as a current collector for catholyte, this cell shows an excellent stability in air atmosphere because the Ni(OH)2‐induced OER capacity in catholyte exactly balances the ORR capacity in anolyte. Such O2‐balance strategy facilitates AORFBs' practical application. [ABSTRACT FROM AUTHOR]

As a green route for large‐scale energy storage, aqueous organic redox flow batteries (AORFBs) are attracting extensive attention. However, most of the reported AORFBs were operated in an inert atmosphere. Herein, we clarify this issue by using the reported AORFB (i.e. 3, 3′‐(9,10‐anthraquinone‐diyl)bis(3‐methylbutanoicacid) (DPivOHAQ)||Ferrocyanide) as an example. We demonstrate that the dissolved O2 can oxidize the discharged DPivOHAQ in anolyte, leading to capacity‐imbalance between anolyte and catholyte. Therefore, this cell shows continuous capacity fading when operated in an air atmosphere. We propose a simple strategy for this challenge, in which the oxygen evolution reaction (OER) in catholyte is employed to balance oxygen reduction reaction (ORR) in anolyte. When using the Ni(OH)2‐modifed carbon felt (CF) as a current collector for catholyte, this cell shows an excellent stability in air atmosphere because the Ni(OH)2‐induced OER capacity in catholyte exactly balances the ORR capacity in anolyte. Such O2‐balance strategy facilitates AORFBs' practical application. [ABSTRACT FROM AUTHOR]

Gliomas are one of the most aggressive primary tumours, accounting for 81% of malignant brain tumours, and are associated with a significant mortality. Therefore, the elucidation of the molecular mechanism underlying glioma progression and identification of promising treatment targets are necessary. Here, the expression of prefoldin (PFDN) 6 in human glioma tissues and cell lines was evaluated using immunohistochemistry and quantitative polymerase chain reaction. Celigo and CCK‐8 assays were performed for assessing cell viability. Flow cytometry was used to analyse apoptosis and cell cycle distribution. Wound‐healing and transwell assays were performed to observe cell migration. Lastly, xenograft models were developed for the in vivo validation of the results, and a human phospho‐kinase array was used to explore the downstream signalling pathways. PFDN6 was upregulated in gliomas, and PFDN6 overexpression was significantly correlated with a low survival rate, estimated glomerular filtration rate (EGFR) expression, and tumour grade and recurrence. Moreover, PFDN6 knockdown significantly attenuated cell proliferation and migration, induced apoptosis, and blocked cell cycle progression in the G2 phase, which was further confirmed in the in vivo experiments. Mechanistically, the effects of PFDN6 may be mediated via the AKT signalling pathway. In conclusion, we showed that PFDN6 promotes glioma development by activating AKT signalling and emphasised the potential of PFDN6 as a crucial target in glioma therapy. [ABSTRACT FROM AUTHOR]

The photonic spin Hall effect (SHE) arises from the spin–orbit interaction of lights and plays an important role in light–matter interactions. The phenomenon of spin‐momentum locking validates photonic SHE with unprecedented abilities in wave manipulation. Here, the directional coupling and spin‐momentum locking in spoof surface plasmon polaritons (SSPP) are demonstrated. The transverse spin angular momentum in SSPP is calculated using effective medium theory and the study shows the spin direction is inherently locked to the propagation direction, thus manifesting the spin–orbit interaction of electromagnetic (EM) waves. The spin‐momentum locking is further verified by projecting linearly and circularly polarized waves onto a scatterer‐SSPP structure. It is observed that the helicity of the incident EM wave governs the propagation direction of excited SSPP modes and the directional coupling originates from constructive and destructive interferences of two orthogonal modes. Reconfigurable transmissions of SSPPs are further demonstrated. The proposed design can find applications in reconfigurable sensors, antennas, and power dividers. This approach demonstrates the spin‐momentum locking in SSPPs and introduces new degrees of freedom to manipulate SSPPs by engineering the helicity and interference of EM waves. [ABSTRACT FROM AUTHOR]

Background: Currently, most studies of ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)‐like protein 4 (Hu antigen D, HuD) focus on nervous system‐related diseases; the role of HuD in the occurrence of skin aging and seborrheic keratosis (SK) has not been reported. Objective: To explore the role of HuD in the occurrence of SK and skin aging and its related clinical significance. Methods: The expression levels of HuD in the skin and blood of healthy people at different ages, SK lesions, and perilesional skin of SK patients were detected by both immunohistochemistry and Western blotting. The mRNA expression levels of HuD in the skin and blood of healthy peoples at different ages were detected by quantitative real‐time reverse transcription‐polymerase chain reaction. The expression level of HuD was compared with the skin of healthy people, SK lesion, and perilesional skin of SK patients of the same age. Results: The immunohistochemistry and Western blotting showed that the expression levels of HuD in SK lesions were higher than those in healthy skin and perilesional skin. The immunohistochemical staining intensity, protein and mRNA expression levels of HuD in the skin and blood of healthy people were correlated with age, which gradually increased with increasing age. Conclusion: HuD is highly expressed in SK lesion and aged skin, indicating that a higher HuD expression level is correlated with occurrence of SK and aging skin; however, its mechanism needs to be further studied. [ABSTRACT FROM AUTHOR]

In recent years, tremendous attention has been paid to the investigation of single‐element 2D materials. These 2D materials mainly consist of elements from group IV and group V such as silicene, phosphorene, and antimonene. Together with other four elements from groups III and VI, they are classified as 2D Xenes and exhibit rich optical and optoelectronic properties such as broadband optical response, strong nonlinearity, ultrafast recovery time, and layer‐dependent bandgap. 2D Xenes can be easily integrated with microfibers and other optical platforms. On the basis of their attracting characteristics, 2D Xenes have been utilized in various functional devices. In this review, the optical and optoelectronic properties of the most intensively studied 2D Xenes are introduced. Their applications in photonic devices including all‐optical modulators, wavelength converters, ultrafast lasers, and photodetectors are explicitly explored. Finally, the challenges and future perspectives of photonic devices based on 2D Xenes are discussed. [ABSTRACT FROM AUTHOR]

The Wenjiaping granite, as one of the few Late Jurassic granites in the Songpan–Garzê fold belt (SGFB), can provide an important clue for comprehensively recognizing the tectonic evolution and mineralization of this belt. In this contribution, we present new age and geochemical data for this pluton to better constrain its petrogenesis and discuss the tectonic and metallogenic implications. LA‐ICP‐MS zircon U–Pb dating shows that the Wenjiaping pluton was emplaced at ~159 Ma. The granite contains minor amphibole, and exhibits slightly peraluminous characteristics (A/CNK = 1.03–1.10) and lower initial Sr–Pb isotope ratios than those of the Liwu Group, which excludes the possibility that the Wenjiaping granite was derived from partial melting of the metasedimentary rock‐dominated Liwu Group as previously suggested. Significantly, high Sr/Y (40.93–54.30), LaN/YbN (39.64–56.64), and K2O/NaO (0.77–1.11) ratios, low MgO (0.47%–0.86%) and Cr (25.1–41.3 ppm) contents, and relatively enriched Sr–Nd–Pb–Hf isotope compositions of the Wenjiaping granite are comparable to those of the Late Triassic adakitic rocks in the SGFB, indicating that they probably share a similar source. Combined with previous researches, we propose that large‐scale detachment of the Jianglang dome caused by post‐collisional lithospheric extension in the SGFB‐induced decompressional partial melting of the Precambrian basement rocks can account for the generation of the Late Jurassic Wenjiaping pluton. In addition, our results also suggest that the Wenjiaping pluton probably cannot supply abundant metal elements for the Liwu‐type Cu‐polymetallic deposits in the Jianglang dome, SGFB. [ABSTRACT FROM AUTHOR]

Compartmentalization is a crucial natural methodology to enable multiple biocatalytic transformations to proceed efficiently. Herein, we report a biocompatible multicompartmental colloidal motor that can achieve autonomous movement in the biological environment through two‐enzyme cascade reactions of immobilized enzymes. The colloidal motors with the heterogeneous multicompartment structure were prepared in one step by microfluidic technology, and the compartmentalized encapsulation of glucose oxidase (GOD) and catalase (CAT) was realized. The fabricated colloidal motor was size controllable by tuning the flow rates of the microfluidic system, and its autonomous movement can be triggered by good responsiveness to the alkaline environment. In glucose medium of pH 7.5, the pH‐responsive alginate cores of the colloidal motor swell to facilitate fuel penetration and enzyme‐catalyzed reactions. The enzyme cascade between GOD and CAT immobilized in the colloidal motor chamber results in the self‐propulsion of the colloid motor in glucose medium. The compartmentalized encapsulation of immobilized enzyme improves the stability of the enzyme and enables multicompartmental colloidal motors to self‐propel in an alkaline intestinal environment through an enzyme cascade reaction. These features indicate that such multicompartmental colloidal motors actuated by enzyme cascade reaction in biocompatible fuel have great potential for co‐encapsulation and autonomous movement in different applications. [ABSTRACT FROM AUTHOR]

A complete small‐signal model of dual‐gate HEMT is proposed, considering the parasitic element effects. To extract the intrinsic elements accurately, the parasitic elements are eliminated by using a new method in this paper. It is realized by constructing two simple three‐port matrices and eliminating them with the features of π‐type and T‐type networks. This method is fast and accurate. Dual‐gate HEMTs could be regarded as a cascode connection of two single‐gate HMETs. A dual‐gate HEMT is fabricated on a commercial 0.25 μm GaAs technology to verify the proposed the extraction method. The result shows a good agreement between measured and simulated data over a wide frequency range. [ABSTRACT FROM AUTHOR]