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Your search keyword '"Lafrenie, Robert"' showing total 10 results
Start Over Author "Lafrenie, Robert" Publisher wiley-blackwell
10 results on '"Lafrenie, Robert"'

1. Induction of apoptosis in B16‐BL6 melanoma cells following exposure to electromagnetic fields modeled after intercellular calcium waves.

Author

Rain, Benjamin D., Plourde‐Kelly, Adam D., Lafrenie, Robert M., and Dotta, Blake T.

Subjects
ELECTROMAGNETIC fields, COMPUTATIONAL electromagnetics, CALCIUM, CANCER cells, NUCLEAR fragmentation, APOPTOSIS, CELL communication
Abstract

Exposure to time‐varying electromagnetic fields (EMF) has the capacity to influence biological systems. Our results demonstrate that exposure to time‐varying EMF modeled after the physiological firing frequency of intercellular calcium waves can inhibit proliferation and induce apoptosis in malignant cells. Single exposure of B16‐BL6 cells to a Ca2+ EMF for 40 min reduced the number of viable cells by 50.3%. Cell imaging with acridine orange and ethidium bromide dye revealed substantial cellular apoptosis, preapoptotic cells, nuclear fragmentation, and large spacing between cells in the Ca2+ EMF condition when compared to the control condition. The ability of Ca2+ EMF to influence the proliferation and survival of malignant cells suggests that exposure to specific EMF may function as a potential anticancer therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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