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With the increasing performance demand from the display market, it has become ever more important to realize wide color gamut requirement. In this paper, we fabricated a series of pTSF green devices, the optimal devices which exhibit excellent performance in the range of CIEx 0.17‐0.22, with the central color point meeting Adobe's green light requirements, showing the advantages in wide color gamut. Additionally, they have comparable performance to existing phosphporescent devices under DCI‐P3 light color, showing the advantages of High Performance and High Color Purity [ABSTRACT FROM AUTHOR]

To explore novel natural product‐based nitrogen‐containing heterocyclic compounds with antiproliferative activity, 20 L‐carvone‐derived pyrimidine‐urea compounds 4a–4t were synthesized through the multi‐step reaction of L‐carvone, and structurally characterized by Fourier transform infrared (FT‐IR), hydrogen‐1 nuclear magnetic resonance (1H‐NMR), Carbon‐13 nuclear magnetic resonance (13C‐NMR), and High‐resolution mass spectrometry (HRMS). Besides, the in vitro antiproliferative activity of the target compounds against HepG2, Hela, and MCF‐7 cells was evaluated by methyl thiazolyl tetrazolium (MTT) assay. According to the results, the target compounds showed certain inhibitory activities against the tested cancer cell lines, and five compounds (4b, 4h, 4k, 4l, and 4t) exhibited better inhibition activities against Hela cells than the positive control (5‐FU). Among them, compound 4b held significant antiproliferative activities against Hela and HepG2 cells, and thus deserved further study as a leading compound of new anticancer drugs. In addition, an effective and reasonable three‐dimensional quantitative structure‐activity relationships (3D‐QSAR) model was built by the Comparative molecular field analysis (CoMFA) method to analyze the relationship between the structures of the target compounds and their antiproliferative activities (expressed as pIC50) against Hela cells, and proven to have good predictive ability. Molecular docking was carried out to study the possible binding modes of compound 4b and Survivin, and it was found that compound 4b could be well embedded into the active site, along with the formation of several hydrogen bonds and hydrophobic interactions. [ABSTRACT FROM AUTHOR]

This study explores the complexities of achieving rapid response speed in OLED displays, particularly focusing on the challenges introduced by driving circuits and inherent capacitance. The proposed measurement system offers an innovative approach to evaluating response times and matching of RGB OLEDs at the device level, presenting a cost‐effective strategy for image quality issues resolution, especially at lower brightness. [ABSTRACT FROM AUTHOR]

Aim: T cells are key immunomodulatory cells in periapical lesions. This study aimed to explore the roles of T cells in chronic apical periodontitis (CAP) using single‐cell RNA sequencing and to further investigate Granzyme A (GZMA) in angiogenesis regulation. Methodology: A total of five CAP samples were collected for single‐cell RNA sequencing. We performed subcluster and lineage‐tracing analyses for T cells. According to differential gene expression, distinct biological functions enriched in T cells of CAP were presented by gene set enrichment analysis (GSEA) and compared with healthy gingiva (data obtained from the GEO database). CellChat was used to explore potential ligand–receptor interactions between T cells and endothelial cells in CAP. The coculture of primary human umbilical vein endothelial cells (HUVECs) and Jurkat T cells, as well as the addition of GZMA recombinant protein, was used to validate the predicted pair of GZMA and coagulation factor II thrombin receptor (F2R) by RT‐PCR, angiogenesis and migration assays. Results: A transcriptomic atlas of 44 746 individual cells was constructed from the periapical lesions of five patients with CAP by single‐cell RNA‐seq, and eight cell types were identified. We identified nine subsets of T cells and deciphered the cellular heterogeneity of T cells in CAP at the functional level by subclustering and GSEA. Lineage tracing revealed a distinct lineage of T cells in CAP and predicted the transition of the T cellular state upon CAP. GSEA revealed multiple biological processes and relevant angiogenesis genes upregulated in CAP T cells. GZMA‐F2R pairs were predicted by cell–cell interactions in CAP. High expression of GZMA and F2R was observed in the coculture of HUVECs and Jurkat T cells, and the proangiogenic capacity of the GZMA recombinant protein was emphasized by in vitro experiments. Conclusions: Our study provides novel insights into the heterogeneity of T cells in periapical lesions and reveals the potential role of GZMA in T cells in regulating angiogenesis in HUVECs. [ABSTRACT FROM AUTHOR]

A series of novel 1‐acyl‐5‐amino‐1,2,4‐triazole‐thioether derivatives containing natural gem‐dimethylcyclopropane ring structure were synthesized from natural biomass resource 3‐carene. Their structures were confirmed by FT‐IR, NMR, ESI‐MS, and elemental analysis. The possible mechanism of regioselectivity for the N‐acylation reaction of 5‐amino‐1,2,4‐triazole with 2‐(2,2‐dimethyl‐3‐propylcyclopropyl) acetyl chloride was explored by DFT theoretical calculation. All the target compounds were evaluated for antifungal activity in vitro against eight plant pathogens, and some target compounds showed good inhibitory activity against the tested pathogens. For example, compounds 1‐(5‐Amino‐3‐((4‐chlorobenzyl)thio)‐1H‐1,2,4‐triazol‐1‐yl)‐2‐(2,2‐dimethyl‐3‐propylcyclopropyl)ethan‐1‐one and 1‐(5‐Amino‐3‐((2,6‐dichlorobenzyl)thio)‐1H‐1,2,4‐triazol‐1‐yl)‐2‐(2,2‐dimethyl‐3‐propylcyclopropyl)ethan‐1‐one exhibited inhibitory rates of 81.6 % and 80.9 % against Cercospora arachidicola and Alternaria solani, respectively, better than that of the commercial fungicide thifluzamide with corresponding inhibitory rates of 75.0 % and 78.6 %. Besides, against Gibberella zeae, most of the target compounds displayed better antifungal activity than the positive control thifluzamide. [ABSTRACT FROM AUTHOR]

With the increasing performance demand from the display market, it has become ever more important to realize wide color gamut and low power consumption. Employing a phosphorescence‐sensitized fluorescence (PSF) mechanism, we introduced a narrow‐spectrum green light‐emitting layer (EML) to the state‐of‐the‐art OLED device structure suitable for mass production and investigate its effect on device performance. Compared with the reference phosphorescent device, the optimal PSF devices have achieved more than 20% efficiency improvement in the range of CIEx 0.17‐ 0.27, showing the advantages of high efficiency and high color purity. [ABSTRACT FROM AUTHOR]

BACKGROUND: Nanopesticides have been proved to be a powerful and promising tool to solve the issues in agriculture. The purpose of the present study was to develop ecofriendly nanopesticide systems by the strategy of comprehensive utilization of two natural biomass resources (bagasse and turpentine oil) because of their incomparable advantages. RESULTS: In this research, a series of nanocellulose carriers ETOCN‐1–ETOCN‐4 (ETOCN, esterified TEMPO‐oxidized cellulose nanofibers) with different degrees of substitution were prepared and characterized by Fourier‐transform infrared (FTIR), X‐ray diffraction (XRD) and transmission electron microscopy (TEM). Then, 21 1,3,4‐thiadiazole‐amide compounds 8a–8u containing gem‐dimethylcyclopropane ring were designed, synthesized and characterized. A preliminary bioassay indicated that compound 8i (R = p‐Br Ph) exhibited broad‐spectrum antifungal activity against the tested fungi. Furthermore, drug‐loading complexes 8i/ETOCN‐1–8i/ETOCN‐4 were fabricated by integration of nanocellulose‐based carriers ETOCN‐1–ETOCN‐4 with bioactive compound 8i, and the drug‐loading capacities, microstructures and sustained‐releasing performance of these complexes were also investigated. According to the observation of scanning electron microscopy (SEM) images of complex 8i/ETOCN‐2, the small‐molecule drug and the carrier formed a well‐distributed and compact complex, which led to the excellent drug‐loading capacity and sustained‐releasing performance in the ethanol/water (1:1, v/v) system. CONCLUSIONS: Complexes 8i/ETOCN‐1–8i/ETOCN‐4 deserved further study as the promising candidates for the development of nanopesticides. © 2022 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

BACKGROUND During the storage and processing of Lilium bulbs, the phenomenon of violet‐red colour change in Lilium bulbs which is different from enzymatic browning often exists, but the specific mechanism is not clear. RESULTS: In this study, we chose six‐year‐old Lilium davidii var. unicolor to study. Bulb scales which were sealed in polyethylene film plastic bags were exposed to room temperature (20 ± 2 °C) treatment for 5 days (12 h of sunshine and 12 h of sun shading). Metabolomics and transcript omics were conducted to elucidate the mechanism of violet‐red color change in Lilium bulbs. The results showed that the color of Lilium bulb scales was obvious violet‐red in 5 days; chromaticity value measuring showed the a values had the most significant upward trend. Metabolomics analysis showed many metabolites produced from the flavonoid biosynthesis pathway showed an upward trend. Transcriptome revealed that flavonoid biosynthesis pathway was significantly enriched, of which 20 synthesis genes were highly regulated expression. Metabolome and transcriptome co‐analysis that up‐regulated expression of flavonoids synthesis genes including ten chalcone synthase, two anthocyanidin reductase, and chalcone isomerase, 3′‐hydroxylase, 3‐hydroxylase, dihydroflavonol 4‐reductase, anthocyanin synthase, anthocyanidin 3‐O‐glucosyltransferase and flavonol synthase were highly positive correlated with epicatechin, rutin and cyanidin 3‐rutinoside. CONCLUSION: Phenotypic, metabolomic and transcriptomic analysis indicated that the up‐related expression levels of genes and accumulated flavonoids related to flavonoid metabolism contributed greatly to the violet‐red colour change in Lilium bulbs. The results of this study will deepen our understanding of the color formation of violet‐red Lilium bulbs and provide the basis for future storage and preservation of Lilium bulbs. © 2021 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Pancreatic cancer is one of the malignant tumors with the worst prognosis, and the 5‐year survival rate of this disease is less than 1%. About 90% of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), and targeting therapy has become a promising treatment for PDAC in recent years. To improve the survival rate, novel therapeutic targets for PDAC are still urgently needed. KIF18B was initially identified as a member of the kinesin family and involved in multiple cellular processes, such as separation of chromosomes in mitosis. Recently, it was found that KIF18B was involved in the growth and development of multiple cancers. However, the potential link between KIF18B and PDAC is still unclear. In this study, we demonstrated that KIF18B was highly expressed in human PDAC tissues, and related with the poor prognosis and clinical features, such as tumor size (*p =.013) and pTNM stage (*p =.025), of patients with PDAC. We further found that KIF18B knockdown blocked the cell proliferation of PDAC in vitro and in vivo, and the cell cycle was arrested caused by KIF18B depletion. Additionally, we also found that KIF18B bound to the promoter region of the cell division cycle associated 8 and thus activated its transcription. Taken together, this study explored the molecular mechanism underlying KIF18B promoting PDAC and provided a novel therapeutic target of this disease. [ABSTRACT FROM AUTHOR]

Carbon‐bonded carbon fiber (CBCF) composites are promising lightweight and high efficient thermal insulators to be applied in aerospace area, but their practical applications are usually restricted by the low mechanical performance and poor oxidation resistance. To overcome these drawbacks, many efforts have been made in the fabrication of ceramic coated CBCF composites. However, the densities of these modified composites are usually very high, which would result in the reduction in their thermal insulation performance. Herein, we prepared a CBCF composite with SiC nanowires enhanced interfibrous junctions and SiOC ceramic coated carbon fibers (SiCNWs‐SiOC‐CBCF). Similar to CBCF, the SiCNWs‐SiOC‐CBCF exhibits a low density of 0.35 g/cm3 and an anisotropic and highly porous architecture. The SiCNWs‐SiOC‐CBCF possesses a compressive strength of 3.8 MPa and a compression modulus of 195.7 MPa in the X (or Y) direction, ~26.7% and 150% higher than those of CBCF respectively. It can also suffer from an isothermal treatment in air at 900°C for 120 minutes. The combination of these properties makes the SiCNWs‐SiOC‐CBCF a good candidate for thermal insulator to be applied in extreme conditions. [ABSTRACT FROM AUTHOR]