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Background: The aim of the study was to explore the outcomes of computed tomography‐guided microwave ablation (MWA) in non‐small cell lung cancer (NSCLC) patients with adjacent lobe invasion (ALI), and to compare the outcomes of ALI‐NSCLC and non‐ALI NSCLC patients after MWA. Methods: A total of 319 NSCLC patients and 366 tumors treated with MWA were included in the study, comprising 34 ALI‐NSCLC patients and 285 non‐ALI NSCLC patients. Complications, local recurrence rates, progression‐free survival (PFS), and overall survival (OS) were compared. Logistic regression analyses were used to investigate the correlation between ALI and the occurrence of pneumothorax after MWA. Results: The mean tumor diameter of ablated tumors was 3.6 ± 2.2 cm. There were 95 (29.8%) NSCLC patients in which pneumothorax occurred after MWA, and all patients recovered. Of these, the ALI group had a significantly higher incidence rate of pneumothorax than the non‐ALI group (52.9% vs. 27.0%, p = 0.002). The median PFS and OS for the ALI group were 12.0 ± 10.2 and 15.5 ± 9.5 months, respectively, and that of the non‐ALI group were 13.0 ± 10.6 and 17.0 ± 11.1 months, respectively, and no significant difference was found in PFS (p = 0.329) nor OS (p = 0.394) between the two groups. Local recurrence rates for ALI and non‐ALI groups were 29.4% and 20.7%, respectively, and no significant difference was found (p = 0.244). Logistic regression analyses revealed that ALI can increase the risk of pneumothorax (hazard ratio [HR], 2.867; p = 0.012). Conclusions: MWA is an effective and safe approach for ALI‐NSCLC treatment. Although ALI can increase the risk of pneumothorax, ALI‐NSCLC patients reveal a comparable outcome to non‐ALI NSCLC patients after MWA. [ABSTRACT FROM AUTHOR]

Four o‐carborane‐based aggregation‐induced emission molecules with ultra‐large Stokes shifts were designed and synthesized. To explore the origin of the ultra‐large Stokes shifts (Δλ ≈ 268–294 nm) of the four target molecules, a new molecule named CZ‐Ph‐PO was synthesized by replacing the o‐carborane unit in CZ‐CB‐PO with a benzene ring. It was found that the ultra‐large Stokes shift was the result of the combined action of diphenylphosphinyl and o‐carborane, in which o‐carborane was the key group. In addition, combined with the single crystal structure analysis, the effect of halogens on molecular photophysical properties was investigated. Our work provides a reference for the design and synthesis of o‐carborane‐based fluorescent molecules with ultra‐large Stokes shifts. [ABSTRACT FROM AUTHOR]

With 2 figures and 2 tables Abstract An extraction and detection method was reported for fat- and water-soluble components in primary soybean seed. The HPLC retention times were 10 min for lutein, 23 min for δ-tocopherol, 27 min for γ-tocopherol, 30 min for α-tocopherol, 33 min for α-carotene and 39 min for β-carotene. The retention times of the isoflavones were 7 min for daidzin, 11 min for genistin, 15 min for malonyldaidzin and 20 min for malonylgenistin. Linear regression and two-way anova analysis were performed, and the test results indicated that there was a significant correlation ( r2 = 0.9973, P < 0.0001) and no significant difference (P = 0.8862 > 0.05) between the traditional method and the proposed method. Moreover, the strain '07-27', which has high α-tocopherol and isoflavone contents in the F2 : 3 lines (F2-derived lines in F3), was screened and then crossed between a high-isoflavone soybean variety, 'Toiku 241', and a high-α-tocopherol soybean variety, 'Keszthelyi A.S.' (pollen parent). The contents of α-tocopherol and total isoflavones were 8.91 and 622.96 mg/100 g DW, respectively. [ABSTRACT FROM AUTHOR]