1. The feasibility of using pathobiome strains as live biotherapeutic products for human use.
- Author
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Jin, Pengfei, Lin, Xiong, Xu, Wenfeng, Li, Kangning, Zhao, Xiaoxiao, Guo, Sirui, Zhao, Zinan, Jiang, Lujie, Liao, Feng, Chang, Longgang, Wang, Min, Liu, Yanmin, Huang, Shaolei, Chen, Zhangran, and Ji, Fusui
- Subjects
ENTEROTYPES ,CO-cultures ,MOLECULAR biology ,HORIZONTAL gene transfer ,BIOLOGICAL evolution ,GENETIC regulation ,GRATITUDE - Abstract
This article explores the potential use of pathobiome strains as live biotherapeutic products for human health. It emphasizes the importance of evaluating these strains at a detailed level, considering factors such as functional genes, ecological niche, and drug interactions. The article acknowledges the role of the gut microbiota in human health and discusses the potential benefits and risks of using pathobiome strains. It also addresses the challenges in developing these products, particularly in terms of safety, efficacy, and quality management. The authors propose further research into gene functions, ecological influences, and the pathogenicity of specific strains, and suggest expanding the applications of live biotherapeutics beyond gastrointestinal diseases. They discuss various development methods, such as large-scale screening and gene editing technology, and highlight the need for further investigation in this field. [Extracted from the article]
- Published
- 2024
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