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Background: Epidemiological and observational studies have indicated an association between Sjögren's syndrome (SS) and Parkinson's disease (PD). However, consistent conclusions have not been reached due to various limitations. In order to determine whether SS and PD are causally related, we conducted a Mendelian randomization study (MR) with two samples. Methods: Data for SS derived from the FinnGen consortium's R9 release (2495 cases and 365 533 controls). Moreover, data for PD were acquired from the publicly available GWAS of European ancestry, which involved 33 674 cases and 449 056 controls. The inverse variance weighted, along with four other effective methodologies, were employed to comprehensively infer the causal relationships between SS and PD. To assess the estimation's robustness, a number of sensitivity studies were performed. To determine the probability of reverse causality, we performed a reverse MR analysis. Results: There was no evidence of a significant causal effect of SS on PD risks based on the MR [odds ratio (OR) = 1.03; 95% confidence interval (CI) = 0.95–1.11; p =.45]. Similarly, no evidence supported the causal effects of PD on SS (OR = 0.92; 95% CI = 0.81–1.04; p =.20). These findings held up under rigorous sensitivity analysis. Conclusions: MR bidirectional analysis did not reveal any cause‐and‐effect relationship between SS and PD, or vice versa. Further study of the mechanisms that may underlie the probable causal association between SS and PD is needed. [ABSTRACT FROM AUTHOR]

This article discusses the case of a female patient with rheumatoid arthritis (RA) who also had early lung adenocarcinoma. The patient was initially treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), but these were ineffective. The patient was then switched to abatacept (ABA), a biological agent, which successfully controlled her disease without any adverse reactions. The article highlights the challenges of treating RA patients with comorbid tumors and discusses the safety and efficacy of different treatment options. However, further research and clinical trials are needed to confirm these findings. [Extracted from the article]

This article discusses a case study of a 55-year-old man with radiographic axial spondyloarthritis (rAxSpA) who experienced a reduction in back pain after engaging in unreasonable stretching and weight-bearing exercises. A computed tomography (CT) scan revealed a thoracic vertebral osteophyte with bone fissures and irregular bony erosions with endplate inflammation in the lumbar vertebral body, consistent with an Andersson lesion (AL). The article emphasizes the importance of appropriate exercise therapy for improving the function and prognosis of patients with rAxSpA, highlighting that high-intensity exercise may lead to spinal fractures. The authors declare no competing interests, and the data supporting the findings are available upon request. [Extracted from the article]

This article discusses a case study of a 32-year-old woman with SAPHO syndrome, a condition characterized by synovitis, acne, pustulosis, hyperostosis, and osteomyelitis. The patient initially presented with palmoplantar pustulosis, nail aberrations, and chest wall pain. After a spontaneous clavicle fracture, she underwent surgery and received treatment with methotrexate, adalimumab, and bisphosphonates, which resulted in fracture resolution. However, after a 5-year interval, a recurrence of clavicle fracture occurred, accompanied by lumbar pain. Imaging revealed bone marrow edema in the lumbar spine, indicating involvement of the lumbar vertebrae. The study highlights the risk of recurrent fractures in SAPHO syndrome and emphasizes the need for clinical attention to this condition. [Extracted from the article]