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Firms responded to the COVID‐19 pandemic by participating in an unprecedented level of corporate social responsibility (CSR). The authors build on the existing CSR and crisis response and disaster relief literatures by examining nine CSR types employed during the pandemic (donating in‐kind, donating money, creating content, free products, free services, communication of operational changes, employee support, financial support, and shifting production). Then, they test the impact of starting versus stopping each CSR type on consumer perceptions of authenticity, attitude, and purchase intentions in two experiments, replicated in 2020, 2021, and 2022. Consumers distinguish between CSR types and rate employee and financial support most favorably and creating content and communication of operational changes least favorably. Starting (vs. stopping or no) CSR increases authenticity and subsequent attitude and purchase intentions. Interestingly, stopping CSR is worse than no CSR in 2020, but no CSR is worse than stopping CSR in 2022. This indicates that consumers discredit firms for stopping CSR during the acute phase of the pandemic but discredit firms for not engaging in any CSR after the acute phase ends. Finally, consumers rate small (vs. large) firms more favorably for engaging in some CSR types. Taken together, these results help inform how firms should engage in CSR activities in response to crises and disasters. [ABSTRACT FROM AUTHOR]

A weighted quantile sum (WQS) regression has been used to assess the associations between environmental exposures and health outcomes. However, the currently available WQS approach, which is based on additive effects, does not allow exploring for potential interactions of exposures with other covariates in relation to a health outcome. In addition, the current WQS cannot account for clustering, thus it may not be valid for analysis of clustered data. We propose a generalized WQS approach that can assess interactions by estimating stratum‐specific weights of exposures in a mixture, while accounting for potential clustering effect of matched pairs of cases and controls as well as censored exposure data due to being below the limits of detection. The performance of the proposed method in identifying interactions is evaluated through simulations based on various scenarios of correlation structures among the exposures and with an outcome. We also assess how well the proposed method performs in the presence of the varying levels of censoring in exposures. Our findings from the simulation study show that the proposed method outperforms the traditional WQS, as indicated by higher power of detecting interactions. We also find no strong evidence that the proposed method falsely identifies interactions when there are no true interactive effects. We demonstrate application of the proposed method to real data from the Epidemiological Research on Autism Spectrum Disorder (ASD) in Jamaica (ERAJ) by examining interactions between exposure to manganese and glutathione S‐transferase family gene, GSTP1 in relation to ASD. [ABSTRACT FROM AUTHOR]

An established neural biomarker of autism spectrum disorder ( ASD) has the potential to provide novel biological and pharmacological targets for treatment. Lower level of inhibition in brain circuits is a leading biomarker candidate. A physiological investigation of the functional levels of inhibition in the cortex of individuals with autism can provide a strong test of the hypothesis. The amplitude of cortical response to the stimulation of adjacent fingers is controlled by the level of cortical inhibition and provides just such a test. Using magnetoencephalography, we recorded the response of the somatosensory cortex to the passive tactile stimulation of the thumb ( D1), and index finger ( D2), and to the simultaneous stimulation of both fingers combined ( D1, D2) of the dominant (right) hand of young subjects with and without autism. For each participant, we measured the response to the stimulation of both fingers combined ( D1, D2) relative to the post hoc sum of the responses to the stimulation of each finger alone ( D1+ D2) in multiple different ways and linearly regressed the ASD and neurotypical ( NT) groups' responses. The resulting slopes were then compared: Smaller slope values imply attenuated response to paired finger stimulation, and enhanced levels of inhibition. The short-latency M40 and mid-latency M80 response slopes of the group with autism obtained in different ways were either significantly smaller, or statistically indistinguishable from NT. The result does not support reduced inhibition in the somatosensory cortex of individuals with autism, contrary to the seminal hypothesis of reduced inhibition. Implications are discussed including refinements of current theory. Autism Res 2013, 6: 542-549. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Emerging evidence for differences between individuals with autism spectrum disorder ( ASD) and neurotypical ( NT) individuals in somatic processing and brain response to touch suggests somatosensory cortex as a promising substrate for elucidating differences in functional brain connectivity between individuals with and without autism. Signals from adjacent digits project to neighboring locations or representations in somatosensory cortex. When a digit is stimulated, i.e. touched, its representation in cortex is directly activated; local intracortical connections indirectly activate nonprimary cortical representations corresponding to adjacent digits. The response of the nonprimary cortical representations is thus a proxy for connection strength. Local overconnectivity in autism implies that the nonprimary/primary response ratios of the ASD group will be higher than those of the NT group. D1 and D2 of the dominant hand of the participant were individually stimulated while we recorded neural responses using magnetoencephalography. The cortical representations of D1 and D2 (somatosensory-evoked fields) were computed from the ensemble-averaged data using (a) dipole model fits and (b) singular value decomposition. Individual adjacent/primary response ratios were measured, and group response ratio data were fitted with straight lines. Local overconnectivity in autism implies steeper ASD vs. NT group slopes. Our findings did not support local overconnectivity. Slopes were found to be significantly shallower for the ASD group than the NT group. Our findings support the idea of local underconnectivity in the somatosensory cortex of the brains of individuals with ASD. Autism Res 2013, 6: 190-200. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Accurate detection of dementia in adults with intellectual disabilities is important for clinical care, program planning, and clinical research. This paper reports on a study that examined two major diagnostic methods that varied in the following ways: (1) the extent to which they relied on clinical judgment; (2) the statistical method used to detect declines; and (3) the sensitivity to declines in functioning. Two methods based on testing were compared with one based on clinical judgment. Data were drawn from annual sequential assessments of 168 adults with intellectual disabilities (78 with Down syndrome and 90 with other etiologies). Agreement between testing and clinical judgment methods was 72–75% depending on testing method used. Clinical judgment produced a higher rate of dementia diagnosis for adults with Down syndrome compared with testing methods, suggesting a possible bias. The authors found that diagnostic criteria were useful both for identifying dementia and for describing its characteristics. Our results suggest that clinical judgment could result in a higher number of adults with Down syndrome diagnosed with dementia than methods based on test batteries. Common results across research studies indicate that combinations of sources of information (interviews/direct testing) would be most useful for dementia diagnosis. Future collaboration across research sites is needed to promote rapid progress in this important area, with emphasis on differential diagnosis. [ABSTRACT FROM AUTHOR]

Diagnosis of dementia in adults with intellectual disabilities requires documentation of clinically significant declines in memory and other cognitive skills, as well as changes in everyday and emotional functioning. To improve diagnostic accuracy in adults with Down syndrome, the authors examined conditions often associated with dementia, as well as tests useful for documentation of decline. Specific aims were to identify psychiatric disorders or medical conditions that increased the odds of a dementia diagnosis; to evaluate the sensitivity and specificity of widely used dementia scales; and to determine which tests, used singly or in combination, most accurately supported the presence of dementia. Participants were 78 adults with Down syndrome. Two methods based on a large test battery and one method based on clinical judgment were used to diagnose dementia. It was found that combinations of tests lead to increased levels of diagnostic sensitivity compared with single tests. When taken in combination with other investigations, our results suggest that assessment for psychiatric disorders, delayed memory decline, adaptive behavior decline, and the presence of seizures would be useful for the diagnosis of dementia and that dementia scales would provide additional useful information. The authors conclude that combinations of tests and scales will be most useful for diagnosing dementia in adults with intellectual disabilities. The authors suggest that further research is needed to promote rapid progress, with studies that focus on common diagnostic methodology, identification of screening instruments, and amounts of decline indicative of dementia. [ABSTRACT FROM AUTHOR]

Children with Down syndrome (DS) and normally developing (ND) children of comparable mental age (16-32 months) were compared in their ability to find things seen in the mirror Tasks included finding a rouge mark on the face, finding the mother, finding a toy, as well as free play before the mirror The 2 groups were found to be equally likely to solve each task and did not differ in pattern of tasks solved or amount of prompting to notice the stimulus With increasing mental age, both groups required less prompting and were more likely to locate the stimulus Children with and without DS were not equally interested in particular tasks, and children with DS were more attentive to the mirror overall, whereas ND children tended to lose interest more rapidly in some task situations The significance of incorrect strategies in searching for the reflected mother or toy was also examined It was concluded that the ability of children with DS to solve different kinds of mirror tasks paralleled that of ND children, but that motivational, attentional, and exploratory differences may exist. [ABSTRACT FROM AUTHOR]

Examines the exploratory behavior of young children with down syndrome. Frequency of exploratory behaviors; Selection of behaviors involving switching attention.

- The communicative behavior of autistic and developmental language delay (DLD) children matched for nonverbal mental age and mean length of utterance (MLU) was compared to that of normally-developing (ND) 2-yr-olds. Autistic children were less able than other children to respond correctly to language or gestures used to direct their attention, used attention directing (pointing, showing) less frequently, and produced more echolalic speech when making requests. DLD and ND children differed only in number of pronouns used while requesting. Attention-directing gestures were associated with receptive and expressive language abilities for autistic, DLD and normal children. [ABSTRACT FROM AUTHOR]