Search

Percent necrosis (PN) following chemotherapy is a prognostic factor for survival in osteosarcoma. Pathologists estimate PN by calculating tumor viability over an average of whole‐slide images (WSIs). This non‐standardized, labor‐intensive process requires specialized training and has high interobserver variability. Therefore, we aimed to develop a machine‐learning model capable of calculating PN in osteosarcoma with similar accuracy to that of a musculoskeletal pathologist. In this proof‐of‐concept study, we retrospectively obtained six WSIs from two patients with conventional osteosarcomas. A weakly supervised learning model was trained by using coarse and incomplete annotations of viable tumor, necrotic tumor, and nontumor tissue in WSIs. Weakly supervised learning refers to processes capable of creating predictive models on the basis of partially and imprecisely annotated data. Once "trained," the model segmented areas of tissue and determined PN of the same six WSIs. To assess model fidelity, the pathologist also estimated PN of each WSI, and we compared the estimates using Pearson's correlation and mean absolute error (MAE). MAE was 15% over the six samples, and 6.4% when an outlier was removed, for which the model inaccurately labeled cartilaginous tissue. The model and pathologist estimates were strongly, positively correlated (r = 0.85). Thus, we created and trained a weakly supervised machine learning model to segment viable tumor, necrotic tumor, and nontumor and to calculate PN with accuracy similar to that of a musculoskeletal pathologist. We expect improvement can be achieved by annotating cartilaginous and other mesenchymal tissue for better representation of the histological heterogeneity in osteosarcoma. [ABSTRACT FROM AUTHOR]

Recent years have seen an increase in actions to address a key feature of food in the Anthropocene: the over‐production and consumption of animal‐based foods or "animalisation" of diets. However, it is unclear whether such efforts can be understood as a coherent institutional level response that will challenge hegemonic dietary biopower, a regime of governance that normalises and reproduces animal‐based food consumption. Building on scholarship that explores food governance initiatives in urban contexts and dietary biopower across a range of empirical cases, this paper explores whether, how, and with what consequences governance actors within urban food partnerships (UFPs) of the UK Sustainable Food Cities (SFC) network are working to reframe dietary biopower so that humans are disciplined to eat less animal‐based food and instead to adopt a more plant‐centred diet. Document analysis and semi‐structured interviews with SFC representatives suggest the breadth and depth of current UFP actions do not add up to a sustained challenge to hegemonic, animal‐based dietary biopower. Rather, they reveal a plant‐centred dietary biopolitical project in the making, while specific cases suggest that this project is more accurately conceptualised as arrested due to the pursuit of food system actions that are counter to and in tension with the promotion of plant‐centred eating. We suggest that a more coherent reframing of dietary biopower would entail urban food governance actors engaging consistently and robustly with the debates surrounding animal‐based foods, as well as identifying and enacting synergies between plant‐centred eating, food poverty, and local economic development agendas. The paper explores whether, how and with what consequences governance actors within the urban food partnerships of the UK Sustainable Food Cities network are working to reframe dietary biopower so that humans are disciplined to eat less animal‐based food and instead to adopt a more plant‐centred diet. [ABSTRACT FROM AUTHOR]

The desire to govern antimicrobial resistance (AMR) in animal agriculture has gained renewed prominence in the UK and international policy and practice in response to growing concern about the impact of AMR infections on human and animal health. This article adopts a more‐than‐human approach inspired by assemblage and biopolitical thinking to explore how diverse actors work to assemble a regime of governance in animal agriculture through their efforts to tackle AMR. How agricultural animals are represented and positioned in this process, and the consequences of these efforts for broader agricultural animal–human relation in UK animal agriculture is also a concern. Qualitative, empirical material is produced from documents published by government, industry organisations, NGOs and retailers. We highlight the negotiated contingencies of actions on AMR in UK animal agriculture and reflect on the limited extent to which they constitute a new front in the regulation of agricultural animals. [ABSTRACT FROM AUTHOR]

Ollier disease (OD) and Maffucci syndrome (MS) are characterized by multiple enchondromas. Patients with MS also have benign vascular overgrowths that become malignant in 8.5% of cases. OD is characterized by multiple enchondromas, typically unilateral in distribution with a predilection for the appendicular skeleton. MS is characterized by multiple enchondromas bilaterally distributed in most of the cases. Both disorders feature multiple swellings on the extremity, deformity around the joints, limitations in joint mobility, scoliosis, bone shortening, leg‐length discrepancy, gait disturbances, pain, loss of function, and pathological fractures. About 50% of patients with OD or MS develop a malignancy, such as chondrosarcoma, glioma, and ovarian juvenile granulosa cell tumor. To better understand the natural history of OD and MS, we reviewed 287 papers describing patients with OD and MS. We also created a survey that was distributed directly to 162 patients through Facebook. Here, we compare the review of the cases described in the literature to the survey's responses. The review of the literature showed that: the patients with OD are diagnosed at a younger age; the prevalence of chondrosarcomas among patients with OD or MS was ~30%; in four patients, vascular anomalies were identified in internal organs only; and, the prevalence of cancer among patients with OD or MS was ~50%. With these data, health care providers will better understand the natural history, severity, and prognosis of these diseases and the prevalence of malignancies in these patients. Here, we recommend new guidelines for the care of patients with OD and MS. [ABSTRACT FROM AUTHOR]

The majority of peripheral musculoskeletal soft tissue masses encountered in routine clinical practice are benign and associated with an excellent prognosis, whereas a small proportion of soft tissue masses are malignant and are associated with higher morbidity and mortality. Owing to the excellent tissue contrast resolution provided, magnetic resonance imaging (MRI) is a primary modality for the diagnostic evaluation of soft tissue masses, particularly for defining the anatomic extent. MRI is also useful for the characterization of soft tissue masses; however, after the exclusion of cysts and lipomas, it is challenging to accurately categorize neoplastic lesions as benign or malignant with conventional anatomic MRI. Quantitative MRI biomarkers obtained with nonconventional pulse sequences are becoming increasingly available, and can improve the accuracy of determining the character of soft tissue masses. In this article we discuss established qualitative and emerging quantitative MRI-based biomarkers available with dynamic contrast-enhanced MRI, diffusion-weighted imaging, and MR spectroscopy and their utility for the characterization of untreated soft tissue masses. Level of Evidence: 5 Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019;50:11-27. [ABSTRACT FROM AUTHOR]

This paper presents the preliminary findings of an empirical study into a specific and novel form of contemporary consumption: "yellow‐sticker shopping." This type of consumption involves the active targeting for purchase of food products that have been reduced in price because they are approaching their expiry date. Given the complexities of food provisioning in austerity Britain, that include both non‐conventional sites like markets and food banks as well as conventional "discounters" and high street supermarkets, the analysis reveals how this form of food provisioning goes far beyond the "cost‐saving" accounts that might be expected. The research uses autoethnographic material in the form of vignette, constructed around research conducted in the North of England, together with analysis of an online discussion forum. Data are thematically analysed using literature on shopping and supermarkets and then organised according to the three dimensions of social practice: materials, competences and meanings. The paper makes three key contributions in relation to the practice of yellow‐sticker shopping. First, that it has distinct spatial and temporal qualities and the role played by the space of the supermarket and its associated fixtures and technologies is important. Second, that the uncertain supply of yellow‐sticker goods results in unpredictability. Successful shopping is celebrated and characterised in ways other than the drudgery often associated with the weekly shop. Third, it reveals an assemblage of competences, skills and knowledge not only in relation to grocery shopping but that take place in the home, around food, its storage and preparation and cooking and recipe knowledge. The paper concludes by outlining further planned research associated with the practice of yellow‐sticker shopping that will contribute to ongoing study into the alternative modes of food provisioning and their spatialities that are characteristic of life in contemporary Britain. [ABSTRACT FROM AUTHOR]

Soil management influences food production, economic performance of farm businesses, and a range of public benefits such as water quality, flood control and aquatic and terrestrial biodiversity. The aim of this paper is to explore the role of participatory research in combining scientific and farmer knowledge of soils to meet these multiple objectives. We use five separate research studies involving communication, consultation and co‐production, carried out in the English East Midlands between 2014 and 2018. We compare the participatory processes for knowledge exchange and their material outcomes and assess them retrospectively against specified criteria for successful application of participatory research. We conclude that, depending on context and scalar fit, multiple approaches to participatory research can be complementary, strengthen engagement and build trust within a farming community, resulting in a greater shared understanding of how to address the soil management objectives of farmers and wider society. [ABSTRACT FROM AUTHOR]

This article explores a form of knowledge politics played out within and between universities and research institutes as sites of certified disciplinary expertise in the agro‐food domain. It investigates the openness of this domain to the expertise of the agro‐food social sciences particularly when challenge‐led research programmes require collaboration across disciplines. A case study is provided by the multi‐discipline field of food security research in the UK involving interviews with key stakeholders. The article examines how this research fieldfield's disciplinary diversity is understood is understood by key stakeholders. Interview data are analysed thematically in terms of the current and potential contribution of social science disciplines, the different ways in which stakeholders imagine social science research, and whether social scientists themselves recognise and align with these different imaginaries. The article concludes by arguing that the field of food security research in the UK is open only selectively to agro‐food social science knowledges and that this is likely to have negative implications for addressing the challenges of food security. Further, if the promise of collaborative working between disciplines in agro‐food research fields is to be made good then the emphasis of agro‐food knowledge politics scholarship and the governance of knowledge‐making needs to change. [ABSTRACT FROM AUTHOR]

Abstract: This article addresses UK society's relationship with meat and specifically explores the extent to which a process of ‘de‐meatification’ is underway in this context and one of the mechanisms involved. It does so through analysis of reporting of the Meat Free Mondays (MFM) campaign in the national and regional British print news media. MFM offers a convenient yet powerful vehicle for trying to understand shifting meanings of meat not least because it directly challenges, and generates debate about the dominant – meat based – diet. The article concludes by arguing that a shift is taking place in the status of meat within UK society with the print news media acting as a mechanism that is working in support of de‐meatification. However, these conclusions are qualified in a number of important ways, including the anthropocentrism of the (de)meatification debate, its geographical variability and its weakly politicised character. [ABSTRACT FROM AUTHOR]

Background: Even though virtually all patients with Ewing sarcoma achieve a radiographic complete response, up to 30% of patients who present with localized disease and up to 90% of those who present with metastases experience a metastatic disease recurrence, highlighting the inability to identify patients with residual disease at the end of therapy. Up to 95% of Ewing sarcomas carry a driving EWS-ETS translocation that has an intronic breakpoint that is specific to each tumor, and the authors developed a system to quantitatively detect the specific breakpoint DNA fragment in patient plasma.Methods: The authors used a long-range multiplex polymerase chain reaction (PCR) technique to identify tumor-specific EWS-ETS breakpoints in Ewing sarcoma cell lines, patient-derived xenografts, and patient tumors, and this sequence was used to design tumor-specific primer sets to detect plasma tumor DNA (ptDNA) by droplet digital PCR in xenograft-bearing mice and patients.Results: Tumor-specific breakpoint DNA fragments were detected in the plasma of xenograft-bearing mice, and the signal correlated with tumor burden during primary tumor growth, after surgical resection, and at the time of metastatic disease recurrence. Furthermore, the authors were able to detect the specific breakpoint in plasma DNA obtained from 3 patients with Ewing sarcoma and in 2 patients the authors were able to detect ptDNA when there was radiographically undetectable disease present.Conclusions: The use of droplet digital PCR to detect tumor-specific EWS-ETS fusion gene breakpoint ptDNA fragments can be developed into a highly personalized biomarker of disease recurrence that can be optimized in animal studies for ultimate use in patients. Cancer 2016;122:3015-3023. © 2016 American Cancer Society. [ABSTRACT FROM AUTHOR]

Drawing on data from a research project that focused on the relationship between the biodiversity of grazing and food quality, this article explores the ecological dimensions of alternative food networks in the UK through the concept of 'styles of ecological engagement'. Context is provided by briefly reviewing two contrasting ways of envisaging the relationship between ecology, food and rural development in policy debates. A qualitative analysis of semi-structured interviews with actors at the centre of 38 alternative food networks and of associated promotional materials enables the identification of five styles of ecological engagement: ecological conserving, ecological harmonising, ecological breed enthusing, ecological localising and ecological re-cognising. The article argues that identification and discussion of these styles of ecological engagement is not only helpful in understanding the ecological heterogeneity of alternative food networks but also signals the ways in which their ecological benefits and contribution to rural development might be sustained and enhanced. [ABSTRACT FROM AUTHOR]

The article discusses research on the safety and feasibility of the addition of pamidronate to chemotherapy for the treatment of osteosarcoma. Cisplatin, doxorubicin, and methotrexate with the addition of 2 milligrams/kilograms/dose of pamidronate was administered monthly to 40 patients with osteosarcoma for 12 doses. Results showed that pamidronate does not impair the efficacy of chemotherapy during the osteosarcoma treatment and may also improve the durability of limb reconstruction.

The article presents information on a study which determined whether repeat resection or amputation improves surgical treatment for patients with soft tissue sarcoma (STS) of the hand. Data reviewed were from patients with STS of the hand who were treated between 1996 and 2005. The assessment of recurrence-free survival (RFS) and functional outcome of hand-preserving procedures was performed based on the Musculoskeletal Tumor Society (MSTS) system. It discusses the findings of the study.

This paper explores the environmental knowledge of small-scale rural landholders and comments on the implications of this for environmental policy. The paper draws on conceptualisations of knowledge as ‘know what’, ‘know why’, ‘know how’ and ‘know who’, recognises a distinction between tacit and codified environmental knowledges and highlights the need to consider the politics of knowledge surrounding environmental issues. Both quantitative and qualitative data are reported, and are derived from structured interviews with 30 small-scale landholders who were participants in a nature and landscape conservation initiative – the Landscape Heritage Scheme – within South Devon, England. These data are used to explore the place of environmental concerns within the land management objectives of respondents; the nature and extent of their environmental knowledge; how a range of factors alongside their environmental knowledge shaped the environmental practices of respondents; and the politics of knowledge associated with the Landscape Heritage Scheme. The paper suggests that small-scale landholders should be of interest to environmental policy, prioritising environmental objectives in their land management, being relatively knowledgeable about the environment and highly responsive to environmental advice and financial incentives that support environmental management. A case is made for developing research in this area, given ongoing processes of rural demographic change and the rising importance within this of an increasingly diverse landholding population. [ABSTRACT FROM AUTHOR]

Genetic techniques have become increasingly prevalent in livestock breeding, associated with new types of knowledge-practice and changes in the institutional and geographical relationships related to animal husbandry. This paper examines the value of Foucault’s concept of ‘biopower’ to theorising livestock breeding and the implications of the rise of genetic knowledge-practices in agriculture, developing the concept to apply to nonhuman animals and to situations where humans and nonhuman animals are co-constituted through particular knowledge-practices and corporeal meetings. It focuses on the idea of ‘population’ as a central component of biopower, and relates this to conceptualisations of biosocial collectivity. Reacting to the inherent humanism of Foucault’s outlining of biopower, the paper argues for its relevance in relation to nonhuman populations, and for heterogeneous conceptualisations of biosocial collectivity. Drawing on research with UK beef cattle and sheep breed societies, the paper explores how, in practice, populations are constructed in relation to the production of particular sorts of truths concerning, and particular modes of intervention in, the lives of nonhuman animals. It explores how heterogeneous biosocial collectivities are constituted around these interventions. The emergence of genetic techniques is shown to transform the processes constituting populations and heterogeneous biosocial collectivities, and this is discussed in terms of a new inflection of agricultural biopower associated with novel interventions in the lives of livestock animals. [ABSTRACT FROM AUTHOR]

This article explores whether vegetarianism is congruent with the alternative food economy. Although it has been largely neglected by scholars concerned with agro-food system alternatives, there are good reasons to undertake an exploration of vegetarianism in this context, not least because of the ethical relationships that it seeks to create within the food system. Drawing on recent work by Hilary Tovey in which she applies Eyerman and Jamison's cognitive approach to social movements, the article conceptualises vegetarianism as a social movement with the potential to effect change within the food system and, ultimately (perhaps), bring about rural development benefits. The article identifies and discusses a number of tensions and contradictions within the cognitive praxis of the vegetarian movement, and between the movement's cognitive praxis and external institutions, raising questions about the congruence between vegetarianism and the alternative food economy. It also makes some suggestions about the ways in which the vegetarian movement might reclaim a place at the table of the alternative food economy and in the process make a contribution to rural development. By way of conclusion, the article identifies a number of areas for possible future empirical research, as well as suggesting that the extension of an invitation to vegetarians to sit at the table of the alternative food economy has provided an interesting opportunity to reflect upon the menu on offer. [ABSTRACT FROM AUTHOR]

Abstract Within society, farm animal welfare is moving up the policy and moral agenda as many of the industrial processes associated with animal farming are now being called into question. In the academy, there is growing intellectual interest in the relationship of humanity to animality and the porosity or otherwise of the biologically and socially constructed boundaries between them. This paper uses the farm animal welfare debate to explore changes in society animal relations by looking in turn at the farm, at farm animals and at the notion of farm animal welfare itself. The paper explores the paradox that for as long as society eats and kills animals for food, we are necessarily bound up in a persistent modernist and essentialist conceptualisation of animals and nature. However, alternative approaches are investigated as part of what might be described as a more postmodern approach to animalian difference. [ABSTRACT FROM AUTHOR]

Here, we address flaws in existing approaches to farmer behavioral change which place undue attention on the individual. Rather, we argue for a more distributed understanding of farmer decision‐making behavior, which includes all relevant actors within a farmers' "ring of confidence" in projects. [ABSTRACT FROM AUTHOR]