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A 38‐year‐old pathologist developed multiple evanescent white dot syndrome (MEWDS). He documented his visual impairment in detail utilizing a light microscope for pathological diagnosis. Notably, the subjective defects illustrated by the patient were in good spatiotemporal agreement with diagnostic outcomes. The present report enhances the understanding of visual impairment associated with MEWDS through a comparative analysis of subjective experiences and objective clinical findings. [ABSTRACT FROM AUTHOR]

Background: Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards. However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear. Methods: We conducted a functional magnetic resonance imaging study and employed an adapted Effort‐Expenditure for Rewards Task in subthreshold depressive (SD) participants (n = 33) and healthy controls (HC) (n = 32). This required participants to choose between a fixed low‐effort/low‐reward and a variable high‐effort/high‐reward option, and then immediately exert effort to obtain corresponding rewards for themselves or for unfamiliar people. Results: Compared with the HC group, the SD group showed blunted activity in the left dorsal anterior cingulate cortex/dorsomedial prefrontal cortex, bilateral anterior insula (AI), and right putamen‐left dorsolateral prefrontal cortex functional connectivity when choosing to exert effort for themselves. Additionally, the SD group exhibited increased willingness and greater activation in the bilateral AI when choosing to exert effort for others. Furthermore, these brain activations and functional connectivity were positively related to self‐reported motivation. Conclusions: These findings show altered motivation during effort‐based decision‐making in individuals with the mild depressive state, particularly with higher motivation for others. Thus, this suggests that motivational behaviors and prefrontal–striatal circuitry are altered in individuals with SD, which can be utilized to discover treatment targets and develop strategies to address mental illness caused by motivation disorders. [ABSTRACT FROM AUTHOR]

Cancer stem‐like cells (CSCs) induce drug resistance and recurrence of tumors when they experience DNA replication stress. However, the mechanisms underlying DNA replication stress in CSCs and its compensation remain unclear. Here, we demonstrate that upregulated c‐Myc expression induces stronger DNA replication stress in patient‐derived breast CSCs than in differentiated cancer cells. Our results suggest critical roles for mini‐chromosome maintenance protein 10 (MCM10), a firing (activating) factor of DNA replication origins, to compensate for DNA replication stress in CSCs. MCM10 expression is upregulated in CSCs and is maintained by c‐Myc. c‐Myc‐dependent collisions between RNA transcription and DNA replication machinery may occur in nuclei, thereby causing DNA replication stress. MCM10 may activate dormant replication origins close to these collisions to ensure the progression of replication. Moreover, patient‐derived breast CSCs were found to be dependent on MCM10 for their maintenance, even after enrichment for CSCs that were resistant to paclitaxel, the standard chemotherapeutic agent. Further, MCM10 depletion decreased the growth of cancer cells, but not of normal cells. Therefore, MCM10 may robustly compensate for DNA replication stress and facilitate genome duplication in cancer cells in the S‐phase, which is more pronounced in CSCs. Overall, we provide a preclinical rationale to target the c‐Myc‐MCM10 axis for preventing drug resistance and recurrence of tumors. [ABSTRACT FROM AUTHOR]

Aims: To evaluate the characteristics of diabetes associated with Werner syndrome. Methods: A literature search was done with search term "Werner syndrome" and "Diabetes". Results and Conclusions: Prevalence of diabetes is extremely high in Werner syndrome. Diabetes associated with Werner syndrome is classified as "accompanied with other diseases and conditions and the one occurring mainly in association with other genetic syndromes." This type of diabetes is marked by accumulated visceral fat and high insulin resistance, despite low body mass index. Thiazolidine derivatives and metformin are effective for glycemic control. New antidiabetic drugs, such as dipeptidyl peptidase‐4 inhibitors and glucagon‐like peptide‐1 receptor agonists, could be potentially beneficial for patients with Werner syndrome. Furthermore, the establishment of diet therapy as well as exercise therapy is warranted. Geriatr Gerontol Int 2021; 21: 142–145. [ABSTRACT FROM AUTHOR]

In 1967, Howard S. Becker gave a widely discussed and polemical presidential address entitled "Whose Side Are We On?" Here he introduced the idea of the hierarchy of credibility. Briefly reviewing the article, I suggest a little of how the world has moved on since then. The core of my analysis links symbolic interactionism to ideas of narrative power, narrative inequality, and narrative othering, sketching out a frame of generic forms of narrative power: domination, exclusion, negotiation, and resistance. I stress the dynamics of the subordinated standpoint and narrative othering. Drawing from a wide range of empirical examples where these processes are featured, I suggest many of us tacitly work with such ideas in our studies. I end by returning to Becker's question—Whose side are we on?—and answer: the side of humanity. Just what we mean by humanity raises contentious value claims, especially in these posthuman times. But understanding our humanities and the value challenge they pose provides the necessary prerequisite for answering Becker's question. From this, political action can flow, and a politics of humanity can be cultivated. [ABSTRACT FROM AUTHOR]

Aim: Sarcopenia is defined as a condition that combines decreased skeletal muscle mass with weakness or decreased physical function. It is well known that in older adults, the presence of sarcopenia is a risk of frailty, falls and physical dysfunction. Patients with Werner syndrome are characterized by visceral fat accumulation and thin limbs, but the prevalence of sarcopenia in patients with Werner syndrome has not been investigated. Methods: A literature search was conducted using Werner syndrome and skeletal muscle as keywords. We also analyzed data from our 7 Werner syndrome patients. Results: A literature search on the relationship between Werner syndrome and skeletal muscle yielded only one article reported from Japan. According to this paper, a decrease in skeletal muscle mass (appendicular skeletal muscle index) was observed in all 9 Werner syndromes investigated. On the other hand, in our 7 Werner syndrome patients, their appendicular skeletal muscle indexes were below the standard value except for one male patient who had continued resistance exercise. Conclusion: The decrease in skeletal muscle mass frequently occurs in patients with Werner syndrome. However, resistance exercise may prevent the appearance of sarcopenia and requires early intervention in patients with Werner syndrome. Geriatr Gerontol Int 2021; 21: 139–141. [ABSTRACT FROM AUTHOR]

Accessible summary • People who attended a community centre for people with learning disabilities talked to researchers about the centre, their school and personal experiences. • The researchers were interested in what the people in the study said about learning disabilities. • This study found that people who attended the centre compared their abilities to those of others around them to make sense of who they are. • People in the study presented themselves positively by describing their abilities in comparison to other people. Previous research has shown that identities and the attributes from which identities are inferred are negotiated within social interaction and language. The identity of having learning disabilities is commonly associated with ascriptions of lesser abilities than other people, and in turn might be inferred from such abilities. This study examines how individuals, potentially ascribed with an identity of having learning disabilities, discursively manage the ascription of abilities and disabilities relative to other people. Semi-structured interviews were carried out with eight individuals categorised as having learning disabilities. Interview transcripts were coded for all references to relative abilities and analysed using discourse analysis. The participants displayed three orientations towards abilities, namely (i) ascribing deficits to ‘others’, (ii) resisting comparisons of deficit and (iii) claiming ‘normal’ attributes. For the participants, these negotiations of relative abilities provide ways of managing specific aspects of identities associated with learning disabilities. [ABSTRACT FROM AUTHOR]

Community has long been a key academic concept and lay narrative, especially in commentaries of rural as opposed to urban life. Although community is proffered as an antidote for a plethora of emotional, social and policy challenges in contemporary Western societies, we argue that it is problematic. Previously, we suggested that community is a device mobilised in response to fears surrounding finitude. In this paper, we again draw on Nancy's theorising of singularity and being-in-common, but also engage with his yet more fundamental conceptualisation of ‘being singular plural’ to suggest directions for new geographies of singular and collective life. [ABSTRACT FROM AUTHOR]