1. Nitration of Pyrrolo[2,1‐a]isoquinolines with NaNO2/HFIP.
- Author
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Huang, Xiang, Li, Yun‐Meng, Zhou, Jing, Pan, Yu‐Yi, Li, Wei, Chen, Xiao‐Hui, Yu, Xin, Pei, Shu‐Chen, and Cui, Hai‐Lei
- Subjects
QUINOLINE ,NITRATION ,SODIUM nitrites ,CHEMICAL reactions ,ISOQUINOLINE ,HETEROCYCLIC compounds - Abstract
A mild nitration of pyrrolo[2,1‐a]isoquinolines has been reached using sodium nitrite as nitro source in HFIP at ambient temperature. A variety of nitro‐bearing pyrrolo[2,1‐a]isoquinoline derivatives has been efficiently prepared in poor to quantitative yields (28–98 %). These products can be easily transformed to primary amines and amide by simple chemical reactions. Treatment of other nitrogen‐containing heterocycles such as pyrrolo[1,2‐a]quinoline and substituted indoles under this developed reaction system afforded nitro‐bearing N‐heterocycles in relatively lower yields (15–19 %). [ABSTRACT FROM AUTHOR]
- Published
- 2024
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