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Purpose: This study aimed to develop a novel exfoliating material with high efficacy and low irritation by synthesizing the Mandelic acid_Carnitine ion pairing complex (M_C complex) and evaluating its exfoliating properties. Additionally, the study assessed the skin improvement effects of the M_C complex through clinical evaluations. Methods: The M_C complex was synthesized in a 1:1 molar ratio of Mandelic acid and Carnitine. Structural characterization was performed using dynamic light scattering and Fourier‐transform infrared spectroscopy. Exfoliating efficacy was evaluated on porcine skin, and clinical assessments were conducted on human subjects to measure various skin improvement parameters. Results: The formation of the M_C complex was confirmed through particle size analysis, zeta‐potential measurements, and FT‐IR spectroscopy. The M_C complex demonstrated superior exfoliating efficacy compared to Mandelic acid alone, especially at pH 4.5. Clinical evaluations showed significant improvements in blackheads, whiteheads, pore volume, depth, density, count, and affected area, as well as skin texture. No adverse reactions were observed. Conclusion: The M_C complex exhibits high exfoliating efficacy and minimal irritation, making it a promising cosmetic ingredient for improving skin health. These findings support its potential as a low‐irritation exfoliating material under mildly acidic conditions, contributing to overall skin health enhancement. [ABSTRACT FROM AUTHOR]

Novel triblock copolymers having self-complementary hydrogen-bonding units were synthesized by using reversible addition-fragmentation transfer polymerization. As characterized by dynamic light scattering and atomic force microscopy, these polymers formed noncovalently crosslinked polymer particles and showed an aggregation behavior by intermolecular and intramolecular interactions. At low concentration, polymers formed nanoparticles, and the particle diameter increased with increasing polymer concentration. Well-ordered hexagonal microstructures were prepared by 'Breath Figure' technique with the triblock copolymers. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 [ABSTRACT FROM AUTHOR]