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The summer of 2022 was particularly notable for the prolonged and extensive hot and dry conditions experienced across the UK. The resultant 2022 drought had widespread impacts and prompted much discussion about the continuing vulnerability of the UK to drought, particularly in the context of anthropogenic warming. Here, we briefly describe the evolution of the drought before focusing on the severity of rainfall, river flow, soil moisture and groundwater level deficits from summer 2022, placing the event into a historical context and addressing the impacts of the drought. We also consider whether the 2022 drought is part of a long‐term trend towards increasing drought severity. [ABSTRACT FROM AUTHOR]

Aims: To examine the role of ex vivo oxytocin metabolism in post‐dose peptide measurements. Methods: The stability of oxytocin (Study 1) and oxytocinase activity (Study 2) in late‐stage pregnancy blood was quantified using liquid‐chromatography tandem mass‐spectrometry (LC–MS/MS) and a fluorogenic assay, respectively. Analyses were conducted using blood from pregnant women (>36 weeks gestation) evaluated in lithium heparin (LH), ethylenediaminetetraacetic acid (EDTA) and BD P100 blood collection tubes with or without protease inhibitors. In addition, plasma oxytocin concentrations following administration of oxytocin 240 IU inhaled, 5 IU intravenous or 10 IU intramuscular in women in third stage of labour (TSL) were analysed using enzyme‐linked immunosorbent assay (ELISA) and LC–MS/MS to understand how quantified peptide concentrations differ between these analytical methods (Study 3). Results: Study 1: Oxytocin was stable in blood collected into EDTA tubes with or without protease inhibitors but not in LH tubes. Study 2: Blood collected into all EDTA‐containing collection tubes led to near‐complete inhibition of oxytocinase (≤100 min). In plasma, a 35% reduction in oxytocinase activity was observed in LH tubes with EDTA added. In plasma from late‐stage pregnancy compared to nonpregnant participants, the oxytocinase activity was approximately 11‐fold higher. Study 3: Plasma oxytocin concentrations from nonpregnant or women in TSL following exogenous oxytocin administration were ≤33 times higher when analysed using ELISA vs. LC–MS/MS methods. Conclusions: Collection of blood from late‐stage pregnant women into tubes containing EDTA inhibits oxytocinase effectively stabilizing oxytocin, suggesting low concentrations of oxytocin after dose administration reflect rapid in vivo metabolism. [ABSTRACT FROM AUTHOR]

Aims: To compare pharmacokinetics (PK) and safety of heat‐stable inhaled (IH) oxytocin with intramuscular (IM) oxytocin in women in third stage of labour (TSL), the primary endpoint being PK profiles of oxytocin IH and secondary endpoint of safety. Methods: A phase 1, randomized, cross‐over study was undertaken in 2 UK and 1 Australian centres. Subjects were recruited into 2 groups: Group 1, women in TSL; Group 2, nonpregnant women of childbearing potential (Cohort A, combined oral contraception; Cohort B, nonhormonal contraception). Participants were randomized 1:1 to: Group 1, oxytocin 10 IU (17 μg) IM or oxytocin 240 IU (400 μg) IH immediately after delivery; Group 2, oxytocin 5 IU (8.5 μg) intravenously and oxytocin 240 IU (400 μg) IH at 2 separate dosing sessions. Results: Participants were recruited between 23 November 2016 to 4 March 2019. In Group 1, 17 participants were randomized; received either IH (n = 9) or IM (n = 8) oxytocin. After IH and IM administration, most plasma oxytocin concentrations were below quantification limits (2 pg/mL). In Group 2 (n = 14), oxytocin IH concentrations remained quantifiable ≤3 h postdose. Adverse events were reported in both groups, with no deaths reported: Group 1, IH n = 3 (33%) and IM n = 2 (25%); Group 2, n = 14 (100%). Conclusion: Safety profiles of oxytocin IH and IM were similar. However, PK profiles could not be established for oxytocin IH or IM in women in TSL, despite using a highly sensitive and specific assay. [ABSTRACT FROM AUTHOR]

Ecological communities can remain stable in the face of disturbance if their constituent species have different resistance and resilience strategies. In turn, local stability scales up regionally if heterogeneous landscapes maintain spatial asynchrony across discrete populations—but not if large‐scale stressors synchronize environmental conditions and biological responses. Here, we hypothesized that droughts could drastically decrease the stability of invertebrate metapopulations both by filtering out poorly adapted species locally, and by synchronizing their dynamics across a river network. We tested this hypothesis via multivariate autoregressive state‐space (MARSS) models on spatially replicated, long‐term data describing aquatic invertebrate communities and hydrological conditions in a set of temperate, lowland streams subject to seasonal and supraseasonal drying events. This quantitative approach allowed us to assess the influence of local (flow magnitude) and network‐scale (hydrological connectivity) drivers on invertebrate long‐term trajectories, and to simulate near‐future responses to a range of drought scenarios. We found that fluctuations in species abundances were heterogeneous across communities and driven by a combination of hydrological and stochastic drivers. Among metapopulations, increasing extent of dry reaches reduced the abundance of functional groups with low resistance or resilience capacities (i.e. low ability to persist in situ or recolonize from elsewhere, respectively). Our simulations revealed that metapopulation quasi‐extinction risk for taxa vulnerable to drought increased exponentially as flowing habitats contracted within the river network, whereas the risk for taxa with resistance and resilience traits remained stable. Our results suggest that drought can be a synchronizing agent in riverscapes, potentially leading to regional quasi‐extinction of species with lower resistance and resilience abilities. Better recognition of drought‐driven synchronization may increase realism in species extinction forecasts as hydroclimatic extremes continue to intensify worldwide. [ABSTRACT FROM AUTHOR]

Disturbance events govern how the biodiversity of ecological communities varies in both space and time. In freshwater ecosystems, there is evidence that local and regional‐scale drivers interact to influence ecological responses to drying disturbances. However, most research provides temporal snapshots at the local scale, whereas few studies encompass a gradient of drying severity spanning multiple years. Using a dataset of rare spatiotemporal extent and detail, we demonstrate how independent and interacting local and regional‐scale factors drive shifts in the α and β diversities of communities in dynamic river ecosystems. We examined aquatic invertebrate assemblage responses to hydrological variability (as characterized by monthly observations of instream conditions) at 30 sites over a 12‐year period encompassing typical years and two severe drought disturbances. Sites varied in their disturbance regimes and hydrological connectivity at both local (i.e. site‐specific) and regional (i.e. river catchment) scales. Whereas α diversity was mainly influenced by local factors including flow permanence and the temporal extent of ponded and dry conditions, both temporal and spatial β diversities also responded to regional‐scale metrics such as the spatial extent of flow and hydrological connectivity. We observed stronger local negative responses for taxa with lower capacities to tolerate drying (i.e. resistance) and/or to recover after flow resumes (i.e. resilience), whereas taxa with functional traits promoting resilience made an increasing contribution to spatial β diversity as hydrological connectivity declined. As droughts increase in extent and severity across global regions, our findings highlight the functional basis of taxonomic responses to disturbance and connectivity, and thus advance understanding of how drying disturbances shape biodiversity in river networks. Our identification of the role of regional hydrological factors could inform catchment‐scale management strategies that support ecosystem resilience in a context of global change. [ABSTRACT FROM AUTHOR]

Sound water policy and management rests on sound hydrometeorological and ecological data. Conversely, unrepresentative, poorly collected, or erroneously archived data introduce uncertainty regarding the magnitude, rate, and direction of environmental change, in addition to undermining confidence in decision-making processes. Unfortunately, data biases and errors can enter the information flow at various stages, starting with site selection, instrumentation, sampling/measurement procedures, postprocessing and ending with archiving systems. Techniques such as visual inspection of raw data, graphical representation, and comparison between sites, outlier, and trend detection, and referral to metadata can all help uncover spurious data. Tell-tale signs of ambiguous and/or anomalous data are highlighted using 12 carefully chosen cases drawn mainly from hydrology ('the dirty dozen'). These include evidence of changes in site or local conditions (due to land management, river regulation, or urbanization); modifications to instrumentation or inconsistent observer behavior; mismatched or misrepresentative sampling in space and time; treatment of missing values, postprocessing and data storage errors. Also for raising awareness of pitfalls, recommendations are provided for uncovering lapses in data quality after the information has been gathered. It is noted that error detection and attribution are more problematic for very large data sets, where observation networks are automated, or when various information sources have been combined. In these cases, more holistic indicators of data integrity are needed that reflect the overall information life-cycle and application(s) of the hydrological data. WIREs Water 2017, 4:e1209. doi: 10.1002/wat2.1209 For further resources related to this article, please visit the . [ABSTRACT FROM AUTHOR]

The article focuses on the impact of winter storms in Great Britain during 2013-2014. It states that heavy rainfall, along with strong winds, high tides and storm surge conditions resulted in groundwater and coastal flooding in many parts of the nation. By the end of November 2013, groundwater levels across Great Britain were generally in normal range, but levels still declined in some boreholes.

The article discusses the pattern of drought and floods in England and Wales in 2012. It states that the month of March is one of the most important droughts for a century observed in the regions. According to the author, the droughts have caused exceptionally depressed groundwater levels as well as spring river flows in both areas.

The inherent variability of the UK's climate achieved an extreme expression in 2012 when one of the most significant prolonged droughts for a century was dramatically terminated by the wettest April to July over England and Wales in almost 250 years. Through late spring and summer, runoff and aquifer recharge rates increased steeply and there were numerous instances of flooding, underlining a hydrological transformation with no close modern parallel at this time of year. This paper reviews the development, severity and impacts of the 2010-2012 drought. It is intended that a companion paper will examine the exceptionally wet conditions which began in April 2012 and resulted in runoff and aquifer recharge patterns very rarely experienced during the summer half-year. [ABSTRACT FROM AUTHOR]

This paper examines the process through which micro-businesses 'go green'. It builds upon previous studies that have identified the different drivers of this greening process. However, rather than a static focus on specific drivers, the study articulates the evolution of environmental practices over time. The paper uses comparative case studies of six micro-businesses to build a composite sequence analysis that plots the greening process from its roots through to large-scale and ambitious ecological projects. The study identifies three distinct stages that businesses pass through during this greening process. This has important implications for policy-makers and advisors as it was found that the support needed by the businesses changed as they passed through these different stages. In particular, it was found that appropriate support is currently lacking at certain key points of the businesses' greening development. The paper therefore adds to current understanding of small business ecological responsibility by showing how activities and drivers change with the level of engagement. Pointers are provided as to how support can be improved. [ABSTRACT FROM AUTHOR]

The article offers information on winter floods in Great Britain from 2015 to 2016. Topics discussed include recorded high flows in Wales and southern England in 1976, daily outflow in December 14, 2006, and estimate of return periods with the use of improved Flood Estimation Handbook (FEH) statistical method. It also mentions the groundwater level in autumn 2015.

Ultra-high sensitivity mass spectrometric strategies for defining the primary structures of highly complex mixtures of glycopolymers are revolutionizing structural glycobiology in the postgenomic era. MS strategies incorporating MALDI-MS and ES-MS/MS enable very complex mixtures from biological extracts and/or glycopolymer digests to be screened, thereby revealing the types of glycans present and, importantly, providing clues to structures that are likely to be functionally important. This lecture will overview strategies employed in our laboratory which enable the glycome of cells, tissues and organs to be examined and the glycoforms of individual glycoproteins to be identified. The types of structural problems that can be solved with current technology will be exemplified by some of our recent research in the following areas: • Development and application of glycomics screening strategies for examining glycosylation changes in cells and tissues of knockout mice. • Defining changes in glycosylation of murine T and B cells upon cytokine activation. • Characterization of the ovarian cancer antigen, CA125. • Sequencing and site analysis of N- and O-glycans in murine ZP3, the putative sperm receptor. • Characterization of mucin glycosylation in cystic fibrosis-related research. • Glyco-proteomic investigations of changes in O-glycosylation of CD8 during T-cell development. • Glyco-proteomic analyses of novel glycosylation of bacterial proteins. [ABSTRACT FROM AUTHOR]