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(c) Histopathology: Shows an infundibulocystic basal cell carcinoma characterized by a relatively well-circumscribed neoplasm showing cystic areas as well as a cleft in the adjacent dermis (hematoxylin-eosin stain original magnification ×10) gl The patient's mother was a 77-year-old woman with a medical history of a single facial nodular BCC, a frontobasal meningioma, and a mandibular plexiform ameloblastoma. Basal cell nevus syndrome (BCNS), also known as Gorlin syndrome (GS), is a tumor predisposing disorder with an autosomal dominant inheritance.1,2 It is caused by mutations in the hedgehog pathway, being I PTCH1 i the most commonly affected gene. Many other syndromes are also associated with the development of multiple facial papules and solid organ neoplasias and should be considered in the differential diagnosis (Table 2).2,10 Patients with I SUFU i mutations also seem to develop less odontogenic keratocysts when compared with patients harboring I PATCHED i mutations. [Extracted from the article]

Background: Novel solutions are needed for expediting margin assessment to guide basal cell carcinoma (BCC) surgeries. Ex vivo fluorescence confocal microscopy (FCM) is starting to be used in freshly excised surgical specimens to examine BCC margins in real time. Training and educational process are needed for this novel technology to be implemented into clinic. Objective: To test a training and reading process, and measure diagnostic accuracy of clinicians with varying expertise level in reading ex vivo FCM images. Methods: An international three‐center study was designed for training and reading to assess BCC surgical margins and residual subtypes. Each center included a lead dermatologic/Mohs surgeon (clinical developer of FCM) and three additional readers (dermatologist, dermatopathologist, dermatologic/Mohs surgeon), who use confocal in clinical practice. Testing was conducted on 30 samples. Results: Overall, the readers achieved 90% average sensitivity, 78% average specificity in detecting residual BCC margins, showing high and consistent diagnostic reading accuracy. Those with expertise in dermatologic surgery and dermatopathology showed the strongest potential for learning to assess FCM images. Limitations: Small dataset, variability in mosaic quality between centers. Conclusion: Suggested process is feasible and effective. This process is proposed for wider implementation to facilitate wider adoption of FCM to potentially expedite BCC margin assessment to guide surgery in real time. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 74-year-old white man presented with multiple erythematous lesions, who was on oral hypoglycemic agents. The histological examination of the patient revealed epidermal atrophy with atypical keratinocytes and dyskeratosis. The patient was diagnosed for chemotherapy-induced inflammation of actinic keratoses. The article discusses 5-Fluorouracil as a cytotoxic drug that acts as an antimetabolite.