1. Do reproductive history and information given through genetic counselling influence patients' decisions on mosaic embryo transfer?
- Author
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Coll, Lluc, Parriego, Mònica, Palacios, Gabriela, Garcia, Sandra, Boada, Montserrat, Coroleu, Buenaventura, Polyzos, Nikolaos P., Vidal, Francesca, and Veiga, Anna
- Abstract
Objective: To assess patients' and embryonic characteristics that may have an influence on the decision to transfer a mosaic embryo. Method: Single centre retrospective cohort study including 1247 PGT‐A cycles. Demographic and clinical factors associated with a decision to transfer a mosaic embryo were studied. Female age, number of previous cycles, previous availability of euploid embryos, history of miscarriages and parity as well as percentage of mosaicism, type of anomaly and chromosome risk were studied in relation to decision‐making. Outcomes after mosaic embryo transfer were assessed. Results: To date, in 7.9% of cycles (99/1247), patients have had to make a decision on the fate of their mosaic embryos. In 23.2% of cycles (23/99), patients decided to transfer. In most cases (79.8%; 79/99), patients underwent genetic counselling before the decision. None of the variables analysed were associated with the patients' decision, although parity and the high‐degree mosaicism (>50%) seemed to be negatively associated with the decision to transfer (18.2% vs. 29.8%, p = 0.294; 10% vs. 32.2%, p = 0.052). Conclusions: Neither reproductive history nor information on mosaic embryo characteristics through counselling seems to be determinative for patients when deciding to transfer a mosaic embryo. Promising and increasing data on clinical outcomes after mosaic embryo transfer will be of utmost importance to soften risk perception regarding mosaic embryos and give a better, simplified and more evidence‐based counselling. Key points: What is already known?Mosaic blastocysts have reproductive potential and can give rise to healthy children. However, there are potential risks after achieving a pregnancy from a mosaic blastocyst. Counselling and decision‐making regarding mosaic embryo transfer are both challenging for genetic counsellors and patients, respectively, and very few studies have assessed this process. What does this study add?This study focuses not only on clinical outcomes achieved after mosaic embryo transfer but on the effect and impact that mosaicism diagnosis has on PGT‐A patients by analysing the mosaic embryo transfer decision‐making process and the influence that patients' background and genetic counselling may have on their decision. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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