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Objective: Specific bioelectrical impedance vector analysis (spBIVA) is a recently proposed technique for the analysis of body composition. The aim of this study was to apply spBIVA to a sample of Italian and Spanish young adults and to define the new bioelectrical references for this Western Mediterranean population., Methods: A sample of 440 individuals (220 from Italy, 220 from Spain; 213 men, 227 women) aged 18-30 years was considered. Anthropometric (height, weight, relaxed upper arm, waist, and calf girths) and bioelectrical (resistance, reactance; 50 kHz, 800 μA) measurements were taken. In order to verify the need for new references, specific bioelectrical values were compared to the reference values for U.S. adults and Italian elderly by tolerance ellipses and Student's t test., Results: The mean specific bioelectrical values (resistivity, Rsp, and reactivity, Xcsp, Ohm·cm) were: Rsp (332.7 ± 41.7 Ω·cm), Xcsp (44.4 ± 6.8 Ω·cm), Zsp (335.6 ± 41.9 Ω·cm) and phase (7.6 ± 0.8°) in men; Rsp (388.6 ± 60 Ω·cm), Xcsp (43.7 ± 7.5 Ω·cm), Zsp (391.0 ± 60.3 Ω·cm) and phase (6.4 ± 0.7°) in women. Italo-Spanish bioelectrical vectors were mainly distributed (>90%) in the lower part of the tolerance ellipses for U.S. young adults, due to a shorter impedance (P < 0.001), indicative of a lower percent fat mass. Compared to Italian elders, they were mainly located in the left side (>90%), due to a higher phase (P < 0.001), indicative of higher body cell mass., Conclusions: These population and age-related differences indicate the need for new specific tolerance ellipses that can be used as references for assessing body composition in young adults from Western Mediterranean populations., (© 2015 Wiley Periodicals, Inc.)

Objectives: The objective of this study is to investigate the association between previously GWAS identified genetic variants predisposing to obesity in Europeans and obesity-related phenotypes in Roma population., Methods: A total of 24 representative single nucleotide polymorphisms (SNPs) were genotyped in 372 individuals belonging to 50 extended families of Roma population. SNPs were tested for association with seven quantitative obesity-related phenotypes in the PLINK program., Results: Risk variants in NEGR1, FAIM2, FTO, and SH2B1 genes were associated with increased adiposity accumulation in Roma population with effect sizes between 0.21 and 0.34 Z-scores for each copy of the BMI increasing allele. Additionally, variants in BDNF and MC4R were significantly associated with adiposity distribution but not with overall fatness. No significant association was detected between obesity-related phenotypes and variants in the first intron of the FTO gene (e.g., rs9939609)., Conclusions: The results of this study suggest that SNPs in or near six genes (BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1) are significantly associated with body fat accumulation and distribution in Roma people. However, the association observed among variants in the first intron of FTO and obesity in European derived populations is not evident in the analyzed Roma sample., (© 2014 Wiley Periodicals, Inc.)

Objectives: Human growth is a complex process that remains insufficiently understood. We aimed to analyze genetic and environmental influences on growth from late childhood to early adulthood., Methods: Two cohorts of monozygotic and dizygotic (same sex and opposite sex) Finnish twin pairs were studied longitudinally using self-reported height at 11-12, 14, and 17 years and adult age (FinnTwin12) and at 16, 17, and 18 years and adult age (FinnTwin16). Univariate and multivariate variance component models for twin data were used., Results: From childhood to adulthood, genetic differences explained 72-81% of the variation of height in boys and 65-86% in girls. Environmental factors common to co-twins explained 5-23% of the variation of height, with the residual variation explained by environmental factors unique to each twin individual. Common environmental factors affecting height were highly correlated between the analyzed ages (0.72-0.99 and 0.91-1.00 for boys and girls, respectively). Genetic (0.58-0.99 and 0.70-0.99, respectively) and unique environmental factors (0.32-0.78 and 0.54-0.82, respectively) affecting height at different ages were more weakly, but still substantially, correlated., Conclusions: The genetic contribution to height is strong during adolescence. The high genetic correlations detected across the ages encourage further efforts to identify genes affecting growth. Common and unique environmental factors affecting height during adolescence are also important, and further studies are necessary to identify their nature and test whether they interact with genetic factors., (Copyright © 2011 Wiley-Liss, Inc.)

The aim of this paper is to verify the existence of dispersion (or variability) dimorphism in several anthropometric traits, i.e., some skeletal, muscular, and adipose dimensions, and to provide an evaluation of this scarcely considered aspect of sex differences. This research focuses on two human samples from two different European regions, Sardinia (Italy) and the Basque Country (Spain). Twenty-three anthropometric measurements were taken. A first qualitative analysis was carried out comparing the profiles of the coefficients of variation of each variable in both sexes. Secondly, the equality of variability was verified with different tests. In the normal case, Student's t-test, as proposed by Sokal and Braumann ([1980] Syst. Zool. 29:50-63), was applied. In the more general case, it was necessary to resort to resampling techniques. A suitable bootstrap test was constructed and the results were compared, when possible, with those obtained by other methods. The measurements showed parallel trends in the two populations. In particular, subcutaneous skinfolds showed significant dispersion dimorphism, with the greatest coefficients of variation in men. We suggest that this result was linked to stronger canalization in female dimensions related to the reproductive function and influenced by sociocultural factors. We also suggest defining dispersion dimorphism, whose existence is confirmed by the results presented in this paper, as a descriptive pattern of phenotype variability in both sexes that can be specific of a given class of anthropometric traits., ((c) 2004 Wiley-Liss, Inc)

Fat distribution was studied in an urban sample of boys and girls 4.5 to 19.5 years from the Basque province of Biscay by means of Principal Component Analysis (PCA) of five skinfolds. The PCA extracted four components, which explained 99.1% of the total variance. The first principal component revealed strong stability across age and sex, and was related to a pattern of central body fat distribution. The three other components, upper-lower trunk fat, lateral-medial trunk fat, and upper-lower extremity fat, showed poor stability due largely to the influence of age and, to a lesser degree, sex. In both sexes, individual scores of the four factors did not show multivariate differences by socioeconomic status when a MANOVA with age, age 2 and age 3 as covariates was done. Nevertheless, the first factor scores were significantly higher only in the poorer socioeconomic group of girls. The results are explained in the context of either different lifestyles related to socioeconomic status, a protective effect against environmental stress on urban males, or greater plasticity of trunk fat relative to extremity fat in females. Am. J. Hum. Biol. 10:799-806, 1998. © 1998 Wiley-Liss, Inc., (Copyright © 1998 Wiley-Liss, Inc.)

Regional differences in the growth of Spanish children were studied by fitting the Preece-Baines Model I to cross-sectional stature data. The function parameters and derived biological variables were used to compare children from seven different studies. Regional differences in growth are interpreted as a result of a geographic variation among Spanish provinces in demographic, public health and nutritional conditions. There are differences between urban samples depending on region. Adult stature (h 1 ) and the pattern of growth differ between urban and rural populations from the interior lands. Males from urban Extremadura, Barcelona and the Basque Country show the tallest adult statures. Adult statures of males from Segovia, Extremadura emigrants and Cuenca are not only the lowest, but the growth pattern shows delay in estimated ages at take-off and PHV compared to the other populations. Estimated age at PHV is later for all male samples compared to Vizcaya, except for the sample of Barcelona-I. Females from Barcelona-II, Segovia and the Basque Country show the tallest adult statures (h 1 ). All of the female samples, except that of urban Extremadura, have an earlier estimated age at PHV compared to the sample from Vizcaya. © 1995 Wiley-Liss, Inc., (Copyright © 1995 Wiley-Liss, Inc., A Wiley Company.)

The association between fat distribution and Heath-Carter anthropometric somatotypes was studied in a sample of Basque children and youth aged 8-19 years. About mid-adolescence, mean somatotype of Basque males changed, diminishing in endomorphy and mesomorphy, and increasing slightly in ectomorphy. For the same period, reduced mesomorphy was the most striking change in the female mean somatotype; meanwhile, there was an increase in endomorphy and a decrease in ectomorphy. Two groups of fat distribution were identified: centripetal and peripheral. Centripetal fat increased with age in both sexes. Fat distribution groups showed the following characteristics: a) mean somatotypes of centripetal and peripheral subjects were significantly different; b) centripetal boys and girls were extreme endomorphs prior to adolescent somatotype change; c) centripetal girls showed high ratings of endomorphy after adolescence; d) mesomorphy was related to a centripetal fat distribution pattern in both sexes; e) using the BMI as a criterion of obesity, only 16.3% of centripetal males and 21.8% of centripetal females were classified as obese; f) obesity was absent among subjects with a peripheral pattern, except for one male showing an endomorphic-mesomorph somatotype; h) the obese showed extreme somatotypes with high endomorphy and mesomorphy, and minimal ectomorphy. © 1994 Wiley-Liss, Inc., (Copyright © 1994 Wiley-Liss, Inc., A Wiley Company.)