1. Who is young at heart and when? Diastolic Doppler data from the mind your heart study.
- Author
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Abuzaid, Ahmed, Cohen, Beth E., Pursnani, Seema, Lahsaeizadeh, Seba, Ristow, Bryan, Shaw, Richard E., Rosenblatt, Andrew, Fang, Qizhi, and Schiller, Nelson B.
- Subjects
AGE distribution ,CARDIOVASCULAR diseases ,CARDIOVASCULAR diseases risk factors ,DIASTOLE (Cardiac cycle) ,DOPPLER echocardiography ,OUTPATIENT services in hospitals ,LONGITUDINAL method ,MENTAL health ,REGRESSION analysis ,RISK assessment ,VETERANS' hospitals ,LOGISTIC regression analysis ,ODDS ratio - Abstract
To further define the age‐related distribution of diastolic function as defined by E/A ratio, in healthy male adults. The age‐sensitive ratio of mitral inflow E‐wave to A‐wave (E/A) velocity is often considered in the evaluation of diastolic function. To appropriately direct a comprehensive evaluation of diastolic function, we sought to improve the characterization of the influence of age on E/A ratio. We analyzed echocardiographic data from the Mind Your heart Study, a cohort of outpatients recruited from two San Francisco Veterans centers to examine the effect of mental health on cardiovascular outcomes. Individuals with a history of heart disease or hypertension were excluded, leaving 313 veterans for analysis. We examined E/A by 5‐year increments and performed linear and logistic regression analysis to predict trends in E/A and E dominance. Within the age ranges of population (54.9 ± 11.5), there is a steady gradual decline in absolute E/A ratio (beta coefficient/year‐ 0.018, P < .001) and the odds of E dominance similarly declines with age (odds ratio/year = 0.89, P < .001). Despite this decline, 90% of individuals below the age of 50 years maintain E dominance. Beyond age 50, 55% maintain E dominance, and beyond age 70, only 28% have E dominance. In this adequately healthy population, age‐related progression of delayed relaxation appears to be a state of normality rather than diastolic dysfunction. Careful attention to specific cutoff points in age and E/A ratio could avoid misinterpretation or inappropriate management. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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