1. Availability of π–Cation Radical in the Oxidative Products of Oxidovanadium Porphyrin: Significance for DNA Binding and Antibacterial Activity.
- Author
-
Muzaddadi, Ijaz Ullah, Murugan, Arumugam, Saha, Shankhadeep, Raman, Natarajan, Selvaraj, Freeda Selva Sheela, Manohar, Arumugam, Kulandaisamy, Antonysamy, Kumar, Pradeep, Borah, Rituraj, Shellaiah, Muthaiah, Ravikumar, C. R., and Hussain, Mohammad Farid
- Subjects
ELECTRON paramagnetic resonance ,NUCLEAR magnetic resonance ,CYCLIC voltammetry ,RADICALS (Chemistry) ,LIGANDS (Chemistry) - Abstract
Oxidovanadium meso‐tetrakis(3,4,5‐trimethoxyphenyl) porphyrin [VO(T(OMe)3PP)] (Complex 1) was prepared. The oxidation product of Complex 1 has been characterized by cyclic voltammetry (CV), UV–visible spectrophotometer, electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) by the addition of SbCl5 to Complex 1. There is a one‐electron oxidation product in Complex 1 that creates π–cation radicals in CV data. This is supported by an IR spectrophotometer. Subsequent EPR spectra verified the initiation of the π–cation monoradical, which subsequently transforms into a triplet state where S = 1. DNA binding and antibacterial analysis with Complex 1 have also been analysed. In the DNA‐binding analysis, the CV data confirm the interaction between Complex 1 and DNA. Furthermore, the fact that Complex 1 is more effective at killing bacteria shows that the metal ion's chelation with the porphyrin ligand makes it more lipophilic. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF