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The article presents a case study of a 52-year-old woman with Fitzpatrick skin type IV and no history of atopy refers for a patch testing with an eight month history of cheilitis and mild eczema of her right hand and left upper arm. It mentions that the patient was diagnosed of acquired leukomnia and was treated with Elocon ointment for six weeks without improvement. It also discusses acquired leukomnia following patch testing and depigmentation after patch testing.

The day after intramuscular injection of vitamin K1 (phytomenadione) into her thigh, a 27-year-old-woman with normal liver function developed a relapsing and remitting eczematous reaction localized to the injection site, and later a further eczematous reaction under an adhesive dressing (Duoderm® ). On patch testing, she was positive to vitamin K1 and cross-reacted to vitamin K4 ; she was also positive to colophonium and to ester gum rosin, the dressing adhesive. Recurrent angioedema persisted for several months and, 2 years later, symptoms were still occurring over the injection sites. Structure-activity relationships among vitamin K allergens are discussed. [ABSTRACT FROM AUTHOR]