140 results on '"Spring, David R."'
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2. Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules.
3. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation.
4. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance.
5. Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics.
6. Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA).
7. Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery.
8. Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters.
9. Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
10. Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
11. Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.
12. Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023).
13. Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489.
14. Multiple-parameter Optimization in Drug Discovery: Example of the 5-HT1B GPCR.
15. Partially Saturated Bicyclic Heteroaromatics as an sp3-Enriched Fragment Collection.
16. A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles.
17. Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.
18. The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
19. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.
20. Linear Aliphatic Dialkynes as Alternative Linkers for Double-Click Stapling of p53-Derived Peptides.
21. Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy.
22. Concise Synthesis of Substituted Quinolizin-4-ones by Ring-Closing Metathesis.
23. Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)pp Gpp.
24. Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials.
25. Die Bekämpfung multiresistenter Bakterien: aktuelle Strategien zur Entdeckung neuer Antibiotika.
26. Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1.
27. Palladium-Catalysed Cross-Coupling of Vinyldisiloxanes with Benzylic and Allylic Halides and Sulfonates.
28. A Concise Total Synthesis of Deoxyschizandrin and Exploration of Its Antiproliferative Effects and those of Structurally Related Derivatives.
29. Aryl-Aryl Bond Formation by the Fluoride-Free Cross-Coupling of Aryldisiloxanes with Aryl Bromides.
30. Fluorescent Sensing and Discrimination of ATP and ADP Based on a Unique Sandwich Assembly of Pyrene-Adenine-Pyrene.
31. The Serratia LuxR family regulator CarR.
32. Novel and Efficient Copper-Catalysed Synthesis of Nitrogen-Linked Medium-Ring Biaryls.
33. Induction-Driven Stabilization of the Anion-π Interaction in Electron-Rich Aromatics as the Key to Fluoride Inclusion in Imidazolium-Cage Receptors.
34. Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules.
35. Diversity-oriented synthesis.
36. Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis.
37. Studies on the Biomimetic Synthesis of the Manzamine Alkaloids.
38. Erzeugung einer Molekülbibliothek mit außergewöhnlicher Gerüstdiversität.
39. Synthesis of Unprecedented Scaffold Diversity.
40. Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis.
41. ChemInform Abstract: The Reductive Cleavage of Picolinic Amides.
42. ChemInform Abstract: Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology.
43. ChemInform Abstract: Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction.
44. ChemInform Abstract: Synthesis of a Novel Polycyclic Ring Scaffold with Antimitotic Properties via a Selective Domino Heck-Suzuki Reaction.
45. ChemInform Abstract: Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy.
46. ChemInform Abstract: Peptide Stapling Techniques Based on Different Macrocyclization Chemistries.
47. ChemInform Abstract: Concise Synthesis of Substituted Quinolizin-4-ones by Ring-Closing Metathesis.
48. ChemInform Abstract: Arene C-H Functionalization Using a Removable/Modifiable or a Traceless Directing Group Strategy.
49. ChemInform Abstract: Concise Copper-Catalyzed Synthesis of Tricyclic Biaryl Ether-Linked Aza-Heterocyclic Ring Systems.
50. ChemInform Abstract: Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials.
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