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Objectives: The aim of this single‐center chart review was to quantify the hematologic response and validated reported outcomes with voxelotor treatment. Methods: Real‐world data were collected retrospectively in patients with sickle cell disease (12–70 years old) who were treated with standard‐of‐care procedures. Data were collected before and during voxelotor treatment. Results: A total of 77 patients with a mean age of 30.4 years were included in the analysis; 30% of patients were children <21 years old. Most patients were female (62%), had a homozygous hemoglobin S (HbSS) genotype (86%), and were treated with concomitant hydroxyurea (HU; 82%). The mean baseline Hb level was 8.3 g/dl, reticulocyte percentage was 11.5%, and total bilirubin was 3.5 mg/dl. The mean duration of voxelotor treatment was 9.7 months (range: 1.9–17 months). Favorable responses to voxelotor treatment and signs of hematologic response after voxelotor treatment included increased Hb levels, decreased reticulocyte percentage, and decreased total bilirubin. In patients treated with concomitant HU, a more robust improvement was noted versus voxelotor alone, suggesting a complementary effect. Recorded adverse events were rare, mild, and self‐limited and resolved with dose modification. Conclusions: Hematologic improvements were observed after voxelotor treatment, with a potential additive benefit with concomitant HU treatment. [ABSTRACT FROM AUTHOR]