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The incidence of nephrolithiasis in kidney donors is rare. The timing and treatment of nephrolithiasis in deceased donor kidneys are not well established. While some programs have proposed ex‐situ rigid or flexible ureteroscopy treatment before transplantation, we report on two cases of kidney stones in the same deceased donor that we treated by flexible ureteroscopy and laser lithotripsy performed during the storage time on a hypothermic perfusion machine. Two deceased donor kidneys were found to have multiple kidney stones discovered on preprocurement CT imaging. The right kidney had less than five 2–3 mm stones, whereas the left had five to ten 1 mm stones with a single 7 mm stone. Both organs were placed on a hypothermic perfusion machine and maintained at a temperature of 4°C. An ex‐vivo flexible ureteroscopy with laser lithotripsy and basket extraction was performed while the kidneys were maintained on Lifeport* perfusion machine. The cold ischemia time was 16.9 and 23.1 h. After 12 months of observational follow‐up, neither recipient had nephrolithiasis, UTI, or other urologic complications. The creatinine values now are 1.17 and 2.44 mg/dL (103.4 and 215.7 μmol/L), respectively. Ex‐vivo flexible ureteroscopy with laser lithotripsy and stone removal on machine‐perfused kidneys appears to be safe and offers a good option to treat graft nephrolithiasis and prevent posttransplant complications. Ureteroscopy serves as a minimally invasive treatment option with direct stone removal. Performing this while on machine perfusion minimizes the ischemic time of the kidney and resultant complications or delays in graft function. [ABSTRACT FROM AUTHOR]

Objectives/hypothesis: To suggest a strategy for transoral removal of hilar and intraparenchymal submandibular stones.Study Design: Retrospective case series.Methods: Retrospective evaluation was performed for 514 consecutive patients with hilar and intraparenchymal submandibular stones treated via endoscopy-assisted surgery from January 2006 to June 2018. Three patients had bilateral stones. The stones were classified as: hilar (type I), posthilar (type II), intraparenchymal (type III), and multiple stones (type IV).Results: The affected glands included 311 with type I, 84 with type II, 65 with type III, and 57 with type IV stones. Stones were successfully removed in 478 glands (92.5%, 478/517). Main treatment techniques included hilum ductotomy in 311 glands, intraparenchymal ductotomy in 68, submandibulotomy in 14, intraductal retrieval in 74, and hilum ductotomy accompanied by intraductal retrieval in 11. At a mean 40-months follow-up of 478 successful cases, clinical outcomes were good in 425, fair in 27, and poor in 26 glands. Postoperative sialograms in 75 stone-free patients were categorized as: type I, normal (n = 6); type II, ectasia or stenosis in the main duct and no persistent contrast on functional films (n = 44); type III, ectasia or stenosis in the main duct and mild contrast retention (n = 15); and type IV, poor shape of the main duct and evident contrast retention (n = 10). Postoperative sialometry of 32 patients revealed no significant differences of the gland function between the two sides.Conclusions: Appropriate use of various endoscopy-assisted approaches helps preserve the gland and facilitates recovery of gland function in patients with different depths of hilo-parenchymal submandibular stones.Level Of Evidence: 4 Laryngoscope, 130:2360-2365, 2020. [ABSTRACT FROM AUTHOR]

Objectives/hypothesis: To assess the long-term results after transoral submandibulotomy for stones located in the deep hilar and intraparenchymal submandibular region.Study Design: Retrospective cohort analysis.Methods: Retrospective evaluation including all patients treated with transoral submandibulotomy for sialolithiasis at a tertiary referral center.Results: Complete stone removal at the first transoral surgical treatment was achieved in 185 of 234 patients (79.1%). One hundred seventy-five of the 234 patients were followed up for a mean of 31.2 ( ± 20.5) months. During the follow-up period, 140 of the 175 patients (80.0%) became symptom free after one operation. In patients with residual symptoms, no further treatment was needed in 12 patients (6.9%) due to the mildness of the symptoms; 23 patients (13.1%) received further therapy, which was successful in 15 cases. Submandibulectomy only had to be performed in 3.4% of the patients with follow-up (6/175). In a questionnaire survey, 91.4% of the patients stated that they would be prepared to have the same operation again.Conclusions: These findings show that transoral removal of submandibular sialoliths located in the deep hilum or adjacent intraglandular parenchyma is an effective treatment that can be assisted by additional measures. The techniques described show high success rates, good long-term results, low complication rates, and they avoided the need for submandibulectomy in >95% of cases.Level Of Evidence: 4. Laryngoscope, 127:2038-2044, 2017. [ABSTRACT FROM AUTHOR]

Endoscopic sphincterotomy (EST) and endoscopic papillary balloon dilation (EPBD) are endoscopic techniques that are used for the removal of bile duct stones. Although EST and EPBD have become established techniques, occasionally the management of bile duct stones may be difficult in cases of large stones, multiple stones, and tapering or tortuosity of the distal common bile duct. In such patients, extracorporeal shock wave lithotripsy, mechanical lithotripsy or electrohydraulic lithotripsy, laser lithotripsy, or surgical intervention may be necessary. Furthermore, recently EST plus a large papillary balloon dilation has been popular for the treatment of difficult bile duct stones. Currently, endoscopic lithotripsy for bile duct stones seems to be a promising standard technique. [ABSTRACT FROM AUTHOR]

We evaluated the usefulness of peroral cholangioscopy (POCS) for residual bile duct stones in patients with complete bile duct clearance confirmed by balloon-occluded cholangiography. A total of 108 patients with common bile duct stones who underwent POCS after extraction of stones via endoscopic sphincterotomy, resulting in complete bile duct extraction confirmed by balloon-occluded cholangiography, were retrospectively evaluated. For the treatment of difficult stones, stones were fragmented by mechanical lithotripsy (ML) or electrohydraulic lithotripsy (EHL). In 26 patients (24%), residual stones were detected with POCS in the lower bile duct. In patients with residual stones, large bile duct stones, juxtapapillary diverticulum, and use of ML or EHL were significantly related to residual stones ( P < 0.05). Although a prospective study is necessary to clarify whether this procedure is appropriate in aspects of cost and benefits, POCS appears to be a useful diagnostic tool for confirming complete extraction of bile duct stones. POCS may be useful, particularly when lithotripsy using ML or EHL is performed and a large pneumobilia exists in the bile duct. [ABSTRACT FROM AUTHOR]

Objective To develop a ureteric retrieval net with advantages over existing stone retrieval methods. Materials and methods In vitro experimental trials comparing the ureteric retrieval net with Dormia baskets were performed with porcine ureters and artificial calculi placed in a proximal or distal position. Results For removing a single, large stone (9 times 6 × 5 mm) the net was slightly better than baskets (100% versus 90%) and it was significantly ( P < 0.001) more effective for removing multiple small stones (2 times 2 × 3 mm to 5 times 4 × 3 mm) in one pass (76% versus 40% with three distal stones; 73% versus 13% with three proximal stones; and 53% versus 3% with six proximal stones). Conclusion This newly developed ureteric retrieval net has a compact design, resulting in minimal resistance during retraction. Its smooth hydrophilic outer surface enhances scooping properties against the luminal wall. The mesh is similar to that in nylon stockings - porous enough to allow flow, yet small enough to capture fragments. It can capture numerous small fragments with one scoop, but can easily disengage them if extraction is not possible. The loop encompasses the entire lumen with the 'pusher' offset to a side wall, allowing maximal space and visualization, and the device can dilate the ureter to facilitate extraction. Clinical studies are in progress to evaluate the full potential of this new device. [ABSTRACT FROM AUTHOR]