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A series of compounds similar to Pracinostat that contained benzimidazole ring and N‐hydroxyacrylamide attached at 5‐ or 6‐position were designed, synthesized, and evaluated as HDAC inhibitors. It was interesting to find that the corresponding derivative 1 with N‐hydroxyacrylamide attached at 5‐position was a potent HDAC inhibitor while the others at 6‐position were not. This is the first time to demonstrate the position difference plays important role in the HDAC inhibitory activities of the cinnamic hydroxamates. [ABSTRACT FROM AUTHOR]

Background: The discovery of the glymphatic system and meningeal lymphatic vessels challenged the traditional view regarding the lack of a lymphatic system in the central nervous system. It is now known that the intracranial lymphatic system plays an important role in fluid transport, macromolecule uptake, and immune cell trafficking. Studies have also shown that the function of the intracranial lymphatic system is significantly associated with neurological diseases; for example, an impaired intracranial lymphatic system can lead to Tau deposition and an increased lymphocyte count in the brain tissue of mice with subarachnoid hemorrhage. Methods: In this study, we assessed the changes in the intracranial lymphatic system after intracerebral hemorrhage and the regulatory effects of repeated transcranial magnetic stimulation on the glymphatic system and meningeal lymphatic vessels in an intracerebral hemorrhage (ICH) model of male mice. Experimental mice were divided into three groups: Sham, ICH, and ICH + repeated transcranial magnetic stimulation (rTMS). Three days after ICH, mice in the ICH+rTMS group were subjected to rTMS daily for 7 days. Thereafter, the function of the intracranial lymphatic system, clearance of RITC‐dextran and FITC‐dextran, and neurological functions were evaluated. Results: Compared with the Sham group, the ICH group had an impaired glymphatic system. Importantly, rTMS treatment could improve intracranial lymphatic system function as well as behavioral functions and enhance the clearance of parenchymal RITC‐dextran and FITC‐dextran after ICH. Conclusion: Our results indicate that rTMS can abrogate ICH‐induced brain parenchymal metabolite clearance dysfunction by regulating intracranial lymphatic drainage. [ABSTRACT FROM AUTHOR]

As the core component of wearable electronic devices, flexible energy storage materials play an irreplaceable role. At present, it is still a challenge to prepare flexible electrode materials with high energy density. In this paper, a polyaniline‐based composite flexible conductive hydrogel (PPG‐P) with a two‐level conductive network is successfully prepared by a secondary induced assembly in situ polymerization method. The special conductive structure greatly promotes the efficiency of charge transfer and the utilization of electroactive substances, so that PPG‐P exhibits excellent electrochemical performance. In a three‐electrode system, PPG‐P has a mass‐specific capacitance as high as 989 F g−1 (0.5 A g−1). After 1000 charge and discharge cycles, the capacitance retention is 87%. Symmetrical flexible supercapacitors based on PPG‐P have high specific capacitance (176 F g−1/0.5 A g−1) and high energy density (15.6 Wh kg−1). After 1000 cycles of constant current charge and discharge, the capacitance maintains 78.1%. The preparation of PPG‐P with a hierarchical structure demonstrates the possibility of achieving high energy density in flexible electrode materials, which has great application potential in the development of energy storage elements in wearable devices. [ABSTRACT FROM AUTHOR]