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In this work, new furopyranone‐ and furocoumarin‐chromone conjugates were successfully synthesized via the one‐pot three‐component condensation reactions of 3‐formylchromone derivatives, 4‐hydroxy‐6‐methylpyrone or 4‐hydroxycoumarin and alkyl or aryl isocyanides in refluxing toluene within 2 h. Molecular docking studies on cyclooxygenase enzymes (COX‐1, COX‐2) indicated that most derivatives have greater or moderate binding affinities than 3‐formylchromone which was used as a reference compound. Even some of the new products showed comparable binding energy towards the relative co‐crystalized ligand into COX‐1 and COX‐2. In general, all of the new products formed one to three hydrogen bonds with amino acid residues in the active site of both enzymes. Furthermore, the cytotoxicity activity of some selected compounds was investigated against human foreskin fibroblast cells (BJ) and human breast cancer cells (MDA‐MB‐231) using the MTT assay. All selected compounds exhibited significant cell growth inhibitory against cancerous cells with varied potencies when compared to 3‐formylchromone. However, they were much less toxic against normal cells. A one‐pot synthesis of new chromone‐based furopyranone and furocoumarin compounds has been developed. Some of the synthesized furopyranone‐ and furocoumarin‐chromone conjugates have been found to show good potent anticancer activities against two different cancer cell lines. Molecular docking studies were performed on cyclooxygenase enzymes (COX‐1, COX‐2). [ABSTRACT FROM AUTHOR]

Abstract: A facile and practical method has been developed for the stereoselective synthesis of coumarin‐4‐carboxamido‐3‐esters via a four‐component reaction between salicylaldehyde, malonic acid, alkyl or aryl isocyanides and various alcohols in acetonitrile at room temperature. Coumarin derivatives have been introduced to be effective in inhibition of cyclooxygenase pathways thus; the potential of new products for interaction into cyclooxygenase enzymes (COX‐1/COX‐2) was screened via in silico molecular docking towards the original compound as an assist for designing the potent inhibitors in the future studies. [ABSTRACT FROM AUTHOR]

Anionic ring opening polymerization of ϵ-caprolactone was studied by using different amounts of two potassium activated initiators containing ethylene glycol ( EG) and polyhedral oligomeric silsesquioxane ( POSS) diol, in tetrahydrofuran and toluene as solvents. The synthesized hydroxyl terminated macromers and linear poly(ϵ-caprolactone) ( PCL) were characterized by proton and carbon nuclear magnetic resonance and gel permeation chromatography ( GPC) techniques. Results showed an increase in molecular weight as the monomer/initiator molar ratio increased from 100 to 151 and 202, while the molecular weight distribution ( MWD) showed a minimum by monomer concentration increase. Moreover, POSS-diol-initiated PCLs showed a higher MWD than the polymers initiated with the EG initiator. This was attributed to the formation of a vesicular structure of POSS diols which was confirmed by optical microscopy. By deconvolution of GPC peaks, the best conditions to synthesize PCL with the narrowest MWD were selected. Finally, the effects of some other parameters were studied in more detail. [ABSTRACT FROM AUTHOR]

A simple, efficient, and high yielding one-pot procedure for the formation of the title compounds (III) is reported proceeding by an iodine-catalyzed pseudo three-component domino coupling of barbituric acids and various benzaldehydes in water. [ABSTRACT FROM AUTHOR]

The four component reaction between chromones, Meldrum′s acid, isocyanides, and alcohols provides biologically interesting products with two stereocenters. [ABSTRACT FROM AUTHOR]

The article presents chemical equations to the article "One-Pot Synthesis of 5-(Furo[3,4-b]chromenyl)-5-hydroxybarbiturates via a Three-Component Cascade Reaction" by M. Teimouri and others, published in the periodical "Tetrahedron Letters" in a 2014 issue.

The article focuses on a study titled "Urotropine-Bromine Promoted Synthesis of Functionalized Oxaspirotricyclic Furopyrimidines via a Domino Knoevenagel Condensation/Michael Addition/alpha-Bromination/Williamson Cycloetherification Sequence in Water," that was published in the 2013 issue of the journal "Tetrahedron."

Alloxans are successfully applied as oxo component in the Passerini reaction with carboxylic acids and isonitriles. [ABSTRACT FROM AUTHOR]