1. An Ethylenediamine-based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials.
- Author
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Ranneh, Abdul‐Hackam, Takemoto, Hiroyasu, Sakuma, Shunya, Awaad, Aziz, Nomoto, Takahiro, Mochida, Yuki, Matsui, Makoto, Tomoda, Keishiro, Naito, Mitsuru, and Nishiyama, Nobuhiro
- Subjects
QUANTUM dots ,HYDROPHILIC compounds ,X-ray diffraction ,NANOPARTICLES ,MOLECULAR structure ,POLYZWITTERIONS - Abstract
Polyzwitterions are employed as coating polymers for biomaterials to induce an antifouling property on the surface. Fine-tuning the betaine structure switches the antifouling property to be interactive with anionic tissue constituents in response to a tumorous pH gradient. The ethylenediamine moiety in the carboxybetaine enabled stepwise protonation and initiated the di-protonation process around tumorous pH (6.5). The net charge of the developed polyzwitterion (PGlu(DET-Car)) was thus neutral at pH 7.4 for antifouling, but was cationic at pH 6.5 for interaction with anionic constituents. Quantum dots coated with PGlu(DET-Car) exhibited comparable stealth and enhanced tumor accumulation relative to the PEG system. The present study provides a novel design of smart switchable polyzwitterion based on a precise control of the net charge. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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