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In conclusion, we recommend patients consider inactivated COVID-19 vaccination before commencing IVF/ICSI treatments to reduce the risk of SARS-CoV-2 infection and severe symptoms during pregnancy that may threaten the well-being of both pregnant mothers and their unborn children. Here, the biochemical pregnancy rates, clinical pregnancy rates and early miscarriage rates were not affected by the vaccination status. Effects of COVID-19 vaccination status, vaccine type, and vaccination interval on IVF pregnancy outcomes in infertile couples. Effects of inactivated COVID-19 vaccinations on the IVF/ICSI-ET live birth rate and pregnancy complication in a population of southern China: A retrospective cohort study. [Extracted from the article]

In the event of a public health crisis, highly effective and sustainable antimicrobial materials and equipment will be urgently needed. Here, the preparation is reported by electrospinning of broad‐spectrum antibacterial nanofibers embedded in a photoactive hydrogen‐bonded organic framework (HOF) of rod‐like nanocrystals ≈60 nm in length. The resulting HOF@PVDF‐HFP nanofibers maintain excellent tensile and breathability characteristics while shielding HOF nanocrystals against acid and alkali corrosion. A series of nanofibers embedded with different amounts and types of HOF nanocrystals are prepared to optimize their efficiency of singlet oxygen (1O2) generation. The 0.5 wt.% HOF‐101‐F@PVDF‐HFP nanofibers exhibit the most efficient 1O2 generation that is enhanced by a factor of almost 2 when compared with the HOF‐101‐F microcrystalline powder. The HOF@PVDF‐HFP nanofibers are demonstrated to highly effectively kill pathogens, including viruses, bacteria, and fungi in 30 min under ambient light conditions. [ABSTRACT FROM AUTHOR]

Summary of main observation and conclusion: OSW‐1 is a well‐known natural saponin with potent antitumor activities. We have designed and prepared a small library of 22 OSW‐1 analogues with a variety of p‐acylamino‐benzoyl groups installed at C2" of the xylose residue, wherein a regioselective (1→3)‐glycosylation of arabinoside 3,4‐diol has been achieved by manipulation of the protecting groups on the imidate donors. Bioassays lead to new structure‐activity relationships as well as two applicable fluorescent probes, which are found to localize to lysosomes in HeLa cells and could be used in further antitumor mechanism studies of OSW‐1 in living cells. [ABSTRACT FROM AUTHOR]

Summary of main observation and conclusion: OSW‐1 is a well‐known natural saponin with potent antitumor activities. We have designed and prepared a small library of 22 OSW‐1 analogues with a variety of p‐acylamino‐benzoyl groups installed at C2" of the xylose residue, wherein a regioselective (1→3)‐glycosylation of arabinoside 3,4‐diol has been achieved by manipulation of the protecting groups on the imidate donors. Bioassays lead to new structure‐activity relationships as well as two applicable fluorescent probes, which are found to localize to lysosomes in HeLa cells and could be used in further antitumor mechanism studies of OSW‐1 in living cells. [ABSTRACT FROM AUTHOR]