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Aim: To evaluate whether three‐dimensional (3D) placental vascular indices and volumes during the first trimester of pregnancy can be used as predictors of subsequent adverse outcomes. Methods: This was a prospective cohort study including women with singleton pregnancies between 10 and 13 weeks. 3D placental volume and vascular indices and uterine artery pulsatility index (UtA‐PI) were measured. Adverse outcomes were defined whether there was any of the following complications: small for gestational age pregnancy, preterm delivery, and preeclampsia. The serum pregnancy‐associated plasma protein‐A (PAPP‐A) and free beta‐human chorionic gonadotropin (β‐hCG) levels were also compared. We analyzed the screening performances of these parameters for prediction of any of adverse outcomes. Results: Of 348 women screened, 300 women were completed follow‐up. Overall, 57 (19.0%) of 300 women developed any of adverse pregnancy outcomes. Multiple logistic regression analysis demonstrated that gestational age—adjusted z‐scores of log10 placental volume (odds ratio [OR], 0.572; 95% confidence interval [CI], 0.416–0.788), log10 placental vascularization flow index (VFI; OR, 0.676; 95% CI, 0.496–0.921), and log10 UtA‐PI (OR, 1.910; 95% CI, 1.335–2.731) were significantly associated adverse pregnancy outcomes. The multivariate model combining placental VFI, placental volume, UtA‐PI, and underweight or obese body mass index exhibited the highest screening performances (AUC = 0.77) and PAPP‐A and β‐hCG did not add any significance to multivariate model. Conclusions: Placental volume and vascular indices at 10–13 weeks of gestation are significantly associated with adverse pregnancy outcomes. Combination of these placental indices and UtA‐PI could improve the screening performance for adverse outcomes. [ABSTRACT FROM AUTHOR]

Mesenchymal hamartoma of the chest wall is a rare, benign lesion that arises from one or more ribs, almost exclusively found in infants. Some cases that developed in the fetal period have been reported, but accurate diagnosis was usually possible only after birth, except in a few cases in which fetal magnetic resonance imaging or computed tomography were performed. We present a case of a congenital mesenchymal hamartoma of the chest wall. Although the diagnosis was not confirmed until birth, the prenatal sonographic examination showed strongly suggestive findings. We review the published reports on this condition, and suggest the prenatal sonographic features. Prenatal sonography is valuable in the differential diagnosis of chest mass. [ABSTRACT FROM AUTHOR]