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Non-small cell lung cancer patients with anaplastic lymphoma kinase or c-ros oncogene 1 mutations who are treated with the tyrosine kinase inhibitor crizotinib rarely develop crizotinib-associated renal cysts (CARCs). Here, we present a case report and review of the literature supporting the hypothesis that CARCs may correlate positively with progression-free survival. [ABSTRACT FROM AUTHOR]

Besides critical and well‐studied roles in maintaining genome stability, DNA repair pathways including base excision repair (BER) are also employed by mammalian cells for targeted events such as the generation of diverse antibody repertoires and the differentiation of pluripotent cells. In this issue of The EMBO Journal, Steinacher et al () provide novel mechanistic insights into the complex role of SUMOylation of key BER proteins during active DNA demethylation—a role they demonstrate to be important for cellular differentiation and that has broader implications for BER as a whole. New work uncovers a surprising trans‐SUMOylation cascade between repair enzymes involved in TET‐dependent oxidative DNA demethylation. [ABSTRACT FROM AUTHOR]